Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Account Director Jobs in South Dakota

Sort By: Relevance

$100K - $125K *

Drive business growth by leveraging industry expertise and relationships to acquire new clients in the manufacturing sector. Collaborate with teams to develop strategic sales plans and enhance client...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$180K - $200K *

Manage the campaign calendar and ensure timely launches by transforming customer requests into actionable specs. Collaborate with cross-functional teams to maintain project alignment and drive success...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$143K - $193K *

Accelerate progress at the forefront of data-driven transformation in life sciences. Collaborate with leadership to shape and execute enterprise data architecture initiatives, ensuring scalable, trust...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$142K - $193K *

Drive enterprise growth by managing complex accounts and executing strategic sales initiatives. Collaborate cross-functionally to deliver customer-centric solutions and achieve measurable business out...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$110K - $155K *

Lead content operations for a federal web services program, managing a team to ensure timely, accurate, and accessible communication. Drive strategic planning, oversee Drupal content management, and e...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Unlock potential by managing month-end and year-end closes, ensuring accurate financial reporting across multiple entities. Collaborate with cross-functional teams to streamline processes and enhance...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $150K *

Champion integrated project management for complex pharmaceutical advertising, leading cross-functional teams to ensure timely delivery within scope and budget while mentoring junior staff and enhanci...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $160K *

Lead engineering efforts by writing production code and mentoring a team. Drive modernization initiatives through Java microservices while managing performance and growth of engineers. Collaborate wit...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$76K - $102K *

Engage in a dynamic role driving client acquisition in the Home-Based Care sector. You'll build a robust pipeline, execute sales strategies, and collaborate cross-functionally to enhance client experi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $156K *

Drive data excellence by leading analytics initiatives, enhancing governance, and integrating systems. Collaborate with leadership to deliver impactful insights and ensure compliance while leveraging...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Staffing

$139K - $170K *

Empower growth by leveraging extensive mortgage technology expertise to drive revenue for financial institutions. This role involves building relationships, developing new accounts, and achieving sale...

United StatesRemote

Reposted 1 month ago

  •   8 - 10 years exp.  •   Enterprise Technology

$181K - $237K *

Unlock potential by developing strategic partnerships and enhancing channel programs. As a leader, you’ll drive market expansion and nurture relationships with brokers and consultants to elevate the a...

United StatesRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Enterprise Technology

$175K - $200K *

Lead the charge in optimizing biomarker program operations, ensuring seamless sample processing from collection to storage. Collaborate across teams to uphold quality and compliance while driving grow...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$175K - $210K *

Transform the Platform organization by owning roadmap planning, development processes, and cross-functional coordination. Drive execution and ensure alignment with business goals while providing leade...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Join a team that's driving financial excellence by managing revenue accounting activities, ensuring compliance with ASC 606, and leveraging advanced analytics to enhance reporting and operational effi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$180K - $200K *

Join a team that's driving growth and expansion for commercial clients. In this role, you'll manage a portfolio, identify opportunities, and collaborate with cross-functional teams to enhance customer...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$85K - $100K *

Drive financial excellence by owning month-end close, reconciliations, and management reporting. Collaborate with leadership to enhance processes and ERP systems, ensuring accuracy and compliance as t...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Food & Beverages

$114K - $135K *

Transform event experiences by leading strategy and execution for high-impact trade shows and corporate events. Collaborate cross-functionally to drive brand awareness and measurable business impact i...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$175K *

Optimize revenue cycle management by leading a dynamic team to enhance processes, drive automation, and ensure compliance in a fast-paced telehealth environment. Collaborate with cross-functional team...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Advance your career by leading medical writing projects in a regulatory environment. Collaborate with cross-functional teams to produce high-quality documents, ensuring compliance with industry standa...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$80K - $175K *

Champion the creation of high-quality regulatory documents, managing writing tasks and leading reviews. Collaborate across teams to ensure clarity and compliance, mentoring junior writers while delive...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $175K *

Transform investment research by evaluating and integrating diverse datasets, enhancing AI-driven workflows, and driving strategic content initiatives to elevate platform value and user experience...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$90K - $100K *

Join a team that's passionate about transforming complex scientific data into engaging communications. Collaborate with cross-functional experts to deliver high-quality medical content and strategies...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$200K - $352K *

Shape the future of marketing compliance by leading automation initiatives, overseeing review processes, and driving collaboration across teams. This hands-on role combines strategic oversight with di...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$125K - $150K *

Champion enterprise growth by managing key client relationships, driving retention and revenue expansion. Leverage insights to create strategies, foster collaboration, and enhance client value through...

United StatesRemote

Reposted 1 month ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.