Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Account Director Jobs in South Dakota

Sort By: Relevance

$80K - $95K *

Lead the charge in tax preparation and compliance, overseeing a team to ensure accurate and timely filing of individual, corporate, and non-profit returns while enhancing workflow efficiency and mento...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $200K *

Accelerate progress at the forefront of product innovation, leading a team to drive strategy and customer experience for a key transaction management platform while embedding AI to enhance efficiency...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Transform the landscape of patient care by maximizing sales and awareness of specialized products. Collaborate with healthcare professionals to ensure compliance and enhance patient outcomes while man...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Empower the go-to-market organization by architecting and optimizing revenue operations, driving AI innovation, and enhancing team productivity through strategic systems thinking and advanced automati...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Pioneer innovative finance systems to enhance automation and reporting. Lead the integration of AI and controls in a fast-growing mental health company, collaborating across teams to ensure scalable f...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Elevate your career by driving strategic partnerships with top utilities. In this senior role, you'll lead complex enterprise sales, build trusted relationships, and shape innovative solutions, all wh...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$160K - $200K *

Unlock potential by leading global integrated campaigns that drive pipeline and revenue. As a player-coach, you'll manage a high-performing team while executing multi-channel strategies that align wit...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$175K - $400K *

Elevate your career by managing the lifecycle of vendor agreements and contracts. Collaborate across departments to ensure compliance and streamline workflows, safeguarding business interests while mi...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $125K *

Join a team that's driving innovation in billing and data platforms. As a Senior Product Owner, you'll lead agile delivery, manage complex features, and ensure high-quality releases while collaboratin...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$198K - $298K *

Lead the charge in shaping the AMER Revenue Operations strategy, driving operational excellence and predictable outcomes. Collaborate with executive leadership to optimize sales processes and build a...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$122K - $187K *

Grow your career by driving strategic sales initiatives within key accounts. Collaborate with C-suite executives to deliver tailored technology solutions, ensuring exceptional customer experiences whi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Drive client growth and strategy for flagship TikTok Shop accounts, leading a team to optimize performance and execute innovative social commerce initiatives. Shape the future of digital commerce thro...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$115K - $135K *

Lead the charge in driving customer success and growth by managing a portfolio of complex accounts, collaborating with finance and IT leaders to enhance digital transformation and optimize payment sol...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$122K - $171K *

Unlock potential by driving data-driven insights for Customer Success. Collaborate across teams to enhance customer journeys, optimize growth strategies, and shape analytics foundations that support A...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$91K - $121K *

Shape the future of project management by leading enterprise initiatives, establishing standards, and ensuring effective execution of organizational priorities in a remote setting...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Accelerate brand transformation by leading a dedicated creative team, ensuring high-quality visual and verbal expression across global campaigns and touchpoints to create memorable customer experience...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$180K - $240K *

Lead strategic business initiatives by building relationships with senior executives to drive revenue growth in life sciences. Develop actionable plans to identify opportunities and enhance market pos...

United StatesRemote

Reposted 1 week ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Empower regulatory excellence by guiding cross-functional teams in compliance and strategy. Leverage deep FDA knowledge to influence promotional materials and ensure adherence to evolving regulations...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Transform the future of talent management by partnering with Product and Technology leaders to design and implement a GM operating model, ensuring effective organizational strategies and people practi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $149K *

Lead the charge in delivering complex product development projects by managing cross-functional teams, ensuring customer satisfaction, and driving operational excellence from initiation to delivery in...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Optimize client success by leading strategic relationships and enhancing revenue cycle performance. Drive measurable improvements, manage escalations, and ensure value realization across healthcare so...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Join our team and take ownership of transforming financial insights into compelling due diligence analyses, ensuring clients make informed decisions. Collaborate with experts to deliver high-quality r...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$180K - $200K *

Unlock potential by leading a dynamic creative team to drive performance-focused video ads. Oversee the entire creative process, from concept to execution, ensuring data-driven decisions enhance custo...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$100K - $120K *

Transform the Small Commercial pricing landscape by owning the product backlog, collaborating with cross-functional teams, and delivering impactful solutions that enhance customer value and drive busi...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$168K - $285K *

Shape the future of financial strategy by leading R&D finance, partnering with executives to drive investment decisions, optimize spending, and enhance forecasting accuracy in a dynamic, AI-driven env...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.