Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$90K - $100K *

Join a dynamic team as you lead the marketing operations, managing budgets, performance metrics, and event strategies to drive member engagement and revenue. Your expertise will shape impactful media...

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$100K *

Champion customer satisfaction by building relationships and providing tailored automotive solutions. Drive sales success through consultative selling and product expertise while maintaining a profess...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$124K - $206K *

Drive the end-to-end revenue marketing strategy to enhance pipeline growth, accelerate revenue, and strengthen market positioning. Lead a cross-functional team to optimize performance and scale impact...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$96K *

Optimize domestic logistics operations and lead a team to ensure efficient, compliant transportation from international vendors, driving continuous improvement and cost savings while collaborating acr...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$190K - $228K *

Drive enterprise Quality and Regulatory governance for U.S. operations, ensuring compliance with FDA regulations and overseeing manufacturing quality in the therapeutic radiopharmaceutical sector whil...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$272K - $374K *

Empower our sales team to drive revenue growth by leading strategic engagements with Federal Systems Integrators. Utilize your expertise to craft account plans, build relationships, and navigate compl...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$94K - $185K *

Pioneer growth in Community Financial Institutions by driving new business through consultative selling and relationship management. Own the sales lifecycle, deliver tailored solutions, and collaborat...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$176K - $220K *

Lead the charge in developing high-performing partnerships and teams to drive growth in North America's aftermarket channel, collaborating across functions to enhance partner performance and customer...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Telecommunications & Hardware

$215K - $235K *

Unlock the future of commercial operations by leading integrated pricing, contract negotiations, and deal management for a $250M ARR business. Drive redesign initiatives, optimize processes with AI, a...

United StatesRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$95K - $115K *

Pioneer construction oversight by translating design into execution. Manage drawings, permitting, and quality assurance efforts to ensure superior results meet high standards and deliver an exceptiona...

1 month ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $110K *

Empower patient care by driving strategic partnerships in healthcare, enhancing access to infusion therapy through meaningful relationships. Engage with medical professionals and build referral networ...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Empower a high-performing sales team to drive revenue growth and exceed targets. Collaborate in a dynamic environment, coaching and inspiring talent while executing strategic sales plans for a global...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Transportation

$136K - $253K *

Transform revenue growth by driving sales of partnership products to Mid Law High Value Accounts. Collaborate with territory owners and manage complex sales cycles while leveraging deep product knowle...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$110K - $135K *

Champion automation sales by driving revenue growth and strategic alignment across regions. Collaborate closely with account managers, utilizing technical expertise to enhance customer relationships a...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $180K *

Empower your career by leading deep foundation and heavy civil projects. Oversee operations, manage budgets, and ensure safety compliance while working locally in a dynamic environment. Join us for co...

3 weeks ago

  •   8 - 10 years exp.  •   Transportation

$88K - $105K *

Lead the management of pharmaceutical programs, ensuring client satisfaction and operational excellence. Oversee daily activities, supervise staff, and drive strategic planning while maintaining stron...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Drive new-client acquisition by managing the full sales cycle, from prospecting to contract signing. Collaborate with marketing and commercial teams to deliver tailored solutions and build executive r...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$120K - $145K *

Transform regulatory strategies for rare disease and cardio-pulmonary drug-device programs. Collaborate with cross-functional teams to ensure compliance and drive successful submissions globally, supp...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $185K *

Drive success by leading a team of outside sales representatives in the roofing industry. Your expertise will guide sales strategies, optimize performance, and foster strong client relationships to ac...

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$125K - $185K *

Elevate our sales performance by leading a team of outside sales reps, driving growth through strategic planning, relationship building, and market analysis. Your expertise in the roofing industry wil...

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$149K - $214K *

Lead the charge in managing client relationships and high-level strategies, leveraging deep digital expertise to drive impactful deliverables and inspire teams while ensuring financial accountability...

6 days ago

  •   8 - 10 years exp.  •   Media

$165K - $185K *

Help us drive growth by partnering with sales and business teams to streamline complex transactions. This role offers a unique opportunity to influence revenue operations and engage directly with clie...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$180K - $195K *

Elevate healthcare marketing by transforming complex science into impactful strategies. Lead multidisciplinary teams to inspire creativity, drive behavior change, and build trusted client relationship...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Drive the future of automotive retail by partnering with dealerships to enhance performance, launch innovative technologies, and deliver exceptional customer experiences. This role requires strategic...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $110K *

Join a team that's driving growth by identifying and closing new client opportunities in experiential marketing. Leverage your network and expertise to engage youth and Gen Z through innovative campai...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.