Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$95K - $115K *

Help us lead the planning and execution of critical programs, ensuring alignment with business objectives while managing risks and coordinating cross-functional teams for successful project delivery...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$86K - $138K *

Lead the strategy and execution of enterprise data exchange products, ensuring secure and standardized data sharing. Collaborate with stakeholders to drive interoperability and maximize business value...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$158K - $250K *

Join a team that's redefining market access strategies in the pharma industry. Leverage your expertise in managed care and payer relationships to drive coverage and reimbursement for innovative therap...

RemoteRemote

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Collaborate cross-functionally to achieve strategic goals in a fast-pace...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $200K *

Drive market and competitive intelligence initiatives to enhance strategic decision-making across teams. Build a high-performing function that delivers insights on customer behavior, market trends, an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$130K - $140K *

Join a dynamic team to lead and shape a new senior living community, driving occupancy, operational excellence, and a culture of high performance. Your leadership will make a meaningful impact on resi...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$150K - $180K *

Join us in leading the heavy haul and specialized logistics sector, overseeing complex shipments from planning to delivery while supporting sales teams and driving business growth through strategic re...

6 days ago

  •   5 - 7 years exp.  •   Transportation

$180K - $200K *

Champion commercial manufacturing excellence by leading technical operations, ensuring on-time delivery of drug products and APIs, and collaborating with regulatory teams to meet compliance and perfor...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Engage with cross-functional leaders to elevate product strategy and execution. Drive innovation in product development, leveraging AI to enhance customer value and business performance across a diver...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$180K - $215K *

Lead regional launch initiatives, driving sales performance and team success through strategic execution and strong customer engagement in a fast-paced environment...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$189K - $222K *

Champion client success by leading post-sale operations, ensuring seamless onboarding, delivery, and retention. Drive growth through strategic account management and operational excellence while foste...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Media

$120K - $135K *

Support the growth of health plan accounts by fostering client relationships, analyzing data, and driving retention in a fast-paced, independent role. Leverage strong communication and analytical skil...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$60K - $120K *

Empower growth by engaging existing customers, identifying upgrade opportunities, and managing the full sales cycle. Build trust with small business owners while driving revenue through effective outr...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $160K *

Drive a structured sales strategy for the US region, achieving targets and creating pipelines through outbound prospecting and tailored solutions while engaging senior stakeholders and maintaining CRM...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Drive growth by owning the full sales cycle in B2B SaaS. Generate pipeline, run demos, and navigate negotiations to close net-new business, all while collaborating with leadership in a dynamic, fast-p...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Shape the future of revenue operations by transforming data into actionable insights. Collaborate with cross-functional teams to enhance performance metrics, streamline reporting, and drive strategic...

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$200K - $225K *

Elevate customer operations by leading Loan Fulfillment, Customer Experience, and Collections teams. Drive efficiency, enhance applicant experiences, and manage vendor relationships to ensure a seamle...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$69K - $92K *

Lead the charge in complex procurement activities, driving supplier performance and cost reduction initiatives while collaborating with internal teams to meet quality and delivery objectives...

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$210K - $324K *

Strategize product innovation and portfolio management for healthcare solutions. Lead cross-functional teams to enhance patient engagement and adherence, driving growth through AI-enabled capabilities...

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $200K *

Reimagine retail leadership as you drive sales growth and develop talent across multiple regions. Lead a team of Regional Directors to enhance patient relationships and execute strategic initiatives...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$262K - $394K *

Accelerate progress at Clio Phones by leading the growth of a cloud-native VoIP platform for law firms. Own P&L, build operational plans, and drive market strategy while managing cross-functional team...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$96K - $181K *

Help us redefine commercial lending by leading product strategy and execution. Drive innovation in loan origination and underwriting, enhancing client experiences and operational efficiency through cr...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$170K - $200K *

Join a team that's redefining financial leadership in a global, multi-site environment. Drive financial reporting, operational finance, and strategic insights while developing talent and ensuring comp...

Reposted 2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$120K - $135K *

Transform the insurance landscape by leading product innovation and development initiatives, enhancing personal Property products to meet member needs and drive profitable growth while ensuring market...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Champion a high-performing team in manufacturing, ensuring quality and safety while driving continuous improvement and employee development in a dynamic production environment...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.