Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$110K - $130K *

Drive efficient order management and logistics operations, ensuring compliance with pharmaceutical regulations while collaborating with internal teams and 3PL partners to optimize product flow and per...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$175K - $205K *

Transform client relationships and drive growth by leading strategic initiatives in scientific visualization, medical education, and digital engagement. Manage multidisciplinary teams and oversee acco...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $200K *

Empower global Salesforce capabilities by leading a dynamic team to drive innovative solutions. Collaborate with stakeholders to align projects with business goals, ensuring effective delivery and man...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$85K - $100K *

Drive operational excellence by managing production, safety, and workforce development in a dynamic manufacturing environment. Lead teams to achieve production goals while ensuring compliance with saf...

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$186K - $234K *

Grow your career by driving sales and building relationships in the neurology and rare disease sectors. Collaborate with healthcare professionals to enhance patient care and achieve sales targets whil...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Drive the future of healthcare operations by leading a $300M portfolio, fostering physician partnerships, and executing growth strategies while managing financial and operational performance for a dyn...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Transform global partner strategies to drive revenue and market share through innovative go-to-market models, collaborating with key stakeholders to establish impactful partnerships and optimize sales...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$120K - $171K *

Elevate business growth in the North American passenger rail market by leading sales strategies for digital technologies. Drive customer partnerships and oversee a high-performing sales team to achiev...

3 days ago

  •   8 - 10 years exp.  •   Transportation

$120K - $145K *

Elevate your career by leading strategic product marketing initiatives, managing high-impact projects, and collaborating cross-functionally to drive value propositions in enterprise technology, includ...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Lead cross-functional teams to drive strategic growth in the Oligo & Peptide market, enhancing industry presence and technical excellence. Partner with leadership to innovate and support global opport...

4 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$98K - $183K *

Join a team that's driving growth in Medical Education by leading B2B sales initiatives. You'll develop strategies, manage a high-performing sales team, and collaborate with cross-functional partners...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$98K - $183K *

Lead the charge in driving new business growth across Medical Education by developing strategies, managing a high-performing sales team, and collaborating with cross-functional partners to expand mark...

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Help us drive revenue growth by developing strategic sales plans and building executive partnerships in the mortgage servicing industry. Leverage your expertise to manage complex sales cycles and enha...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $180K *

Elevate client relationships by managing strategic Tier 1 accounts, driving revenue growth, and ensuring customer satisfaction. Collaborate cross-functionally to develop account strategies and deliver...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$90K - $110K *

Elevate customer relationships and drive growth in the food, pharmaceutical, and personal care sectors by connecting clients with high-quality ingredient solutions. Collaborate cross-functionally to d...

4 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

$350K - $450K *

Accelerate growth by leading a top-tier sales team to drive innovative cloud contact center solutions, ensuring customer transformation through strategic enterprise engagements and robust pipeline man...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $100K *

Accelerate business growth by owning the full sales cycle and expanding strategic partnerships with enterprise retailers. Leverage insights to consistently exceed revenue targets and drive impactful s...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Media

$200K - $255K *

Lead the charge in shaping a cutting-edge data platform that enhances data architecture, governance, and operational effectiveness, driving cross-product adoption and ensuring alignment with business...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$210K - $250K *

Accelerate success by leading our BEC Legal Systems business, driving strategic direction, P&L ownership, and operational excellence to enhance customer satisfaction and market leadership in B2B SaaS...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$246K - $332K *

Transform the future of field operations by leading strategic initiatives that enhance commercial effectiveness and drive measurable impact across customer-facing teams. Collaborate with cross-functio...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Elevate regional sales performance by leading a high-impact team, executing strategic launches, and fostering key customer relationships in a dynamic, fast-paced environment. Drive accountability and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Drive growth as an integral part of our Commercial Sales Team, managing key health system relationships and closing complex deals, while collaborating across departments and shaping the product roadma...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$150K - $180K *

Lead the charge in technical product management, driving strategy and execution for managed accounts integrations. Collaborate across teams to deliver innovative solutions that meet client needs and e...

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $110K *

Accelerate program implementation and stakeholder engagement in pharmaceutical market access. Oversee daily operations, client relations, and staff management while ensuring adherence to budgets and p...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$270K - $290K *

Accelerate progress by managing national broker relationships to enhance revenue and referrals. Collaborate with cross-functional teams to execute strategic initiatives, driving growth through coachin...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.