Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Vice President, Sales Jobs in Missouri

Sort By: Relevance

$165K - $195K *

Unlock potential by leading Partner Hub advertising initiatives for enterprise hospitality clients. Drive renewals, new business, and campaign management while collaborating with cross-functional team...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $100K *

Accelerate business growth by owning the full sales cycle and expanding strategic partnerships with enterprise retailers. Leverage insights to consistently exceed revenue targets and drive impactful s...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Media

$210K - $250K *

Accelerate success by leading our BEC Legal Systems business, driving strategic direction, P&L ownership, and operational excellence to enhance customer satisfaction and market leadership in B2B SaaS...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$246K - $332K *

Transform the future of field operations by leading strategic initiatives that enhance commercial effectiveness and drive measurable impact across customer-facing teams. Collaborate with cross-functio...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Elevate regional sales performance by leading a high-impact team, executing strategic launches, and fostering key customer relationships in a dynamic, fast-paced environment. Drive accountability and...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$75K - $90K *

Join a dynamic team to drive B2B sales growth through innovative data solutions. This role empowers you to engage prospects, craft compelling conversations, and lead the sales journey with a focus on...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Engage in new business acquisition by identifying, qualifying, and closing sales opportunities. Build strong client relationships and deliver tailored presentations while achieving sales quotas in a d...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $110K *

Elevate your career by managing a diverse portfolio of retail and industrial properties across multiple states. This hands-on role focuses on operational excellence, financial performance, and tenant...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$125K - $150K *

Elevate partner relationships in a strategic leadership role responsible for guiding a team and enhancing partner success through AI-driven workflows and high-touch service...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$120K *

Empower the national brand by leading social media strategy, driving engagement, and fostering partnerships. Oversee content creation and analytics to enhance audience reach and conversion across dive...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Media

$80K - $95K *

Drive revenue growth by building relationships and providing tailored solutions for industrial and commercial tool rental needs. Leverage expertise in product lines to enhance customer satisfaction an...

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$64K - $113K *

Help us drive sales growth by managing customer relationships, identifying revenue opportunities, and collaborating with cross-functional teams to enhance product visibility and maximize effectiveness...

3 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$100K - $140K *

Lead the charge in driving revenue growth and client retention by managing strategic relationships and optimizing operational strategies for a diverse portfolio of enterprise clients in the transporta...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Transportation

$160K - $200K *

Collaborate with brokers and clients to drive profitable business through expert underwriting of complex accounts. Leverage strategic insights and relationship-building to optimize portfolio performan...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Drive growth across the Americas by leading sales strategies, building key relationships, and delivering innovative solutions that enhance airport performance. Shape the future of airport operations w...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$100K - $120K *

Unlock potential by driving complex sales in supply chain for mid-market and enterprise accounts. Collaborate with partners, manage pipelines, and deliver tailored solutions to achieve new-business gr...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$119K - $221K *

Advance your career by driving strategic sales initiatives within large enterprises. Collaborate with cross-functional teams to exceed sales quotas and develop innovative solutions that meet client ne...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$130K - $150K *

Accelerate growth by managing sales strategies across CA and parts of the Midwest. Lead market development efforts, achieve sales goals, and collaborate with cross-functional teams to enhance customer...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$147K - $217K *

Transform life sciences analytics by leading innovative measurement strategies, mentoring teams, and advising clients. Drive impactful insights and foster collaboration across disciplines to enhance m...

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$100K - $125K *

Join a team that's redefining enterprise sales by driving new business through consultative strategies. Leverage your expertise to manage complex sales cycles, engage C-suite stakeholders, and exceed...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Business Services

$81K - $142K *

Champion the growth of channel partnerships across North America, driving distributor performance and strategic key account sales in industrial printing solutions. Leverage market insights to enhance...

Missouri, USRemote

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$147K - $217K *

Transform your career by leading innovative analytics in life sciences. Drive impactful strategies, mentor teams, and collaborate with clients to enhance marketing measurement and insights, all while...

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$147K - $217K *

Lead transformative analytics initiatives in life sciences, driving innovation and client success. Mentor teams, enhance measurement standards, and collaborate cross-functionally to deliver actionable...

RemoteRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$160K - $200K *

Join a team that's driving growth in the dynamic SaaS landscape. Lead strategic sales initiatives, manage top-tier talent, and engage with Fortune 500 clients to deliver impactful solutions that prope...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$162K - $238K *

Design and optimize R&D operations to enhance organizational effectiveness through data-driven insights, collaboration, and governance. Partner cross-functionally to drive continuous improvement and e...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.