Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

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$80K - $110K *

Unlock potential by developing seamless integrations for secure file transfers. You will enhance Hyland OnBase solutions and support efficient business operations, ensuring compliance and reliability...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$138K *

Transform infrastructure reliability and automation as a DevOps Engineer. Own critical architecture, drive system performance, and enhance security for financial solutions that empower millions of wor...

US-AnywhereRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $180K *

Empower a high-performing culture by leading HR strategies that attract, develop, and retain top talent. Collaborate with leadership to enhance employee engagement and drive initiatives aligned with t...

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$160K - $200K *

Help us shape the future of our organization by leading HR initiatives that foster a high-performing, inclusive culture. Collaborate with leadership to attract, develop, and retain top talent while dr...

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$160K - $200K *

Join a dynamic team as a strategic leader, driving HR initiatives to foster a high-performing, inclusive culture. Collaborate with senior leadership to enhance talent acquisition, employee engagement...

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$79K - $118K *

Lead the charge in delivering exceptional pediatric emergency care, coordinating comprehensive patient treatment while ensuring safety and therapeutic standards in a dynamic, supportive environment fo...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $118K *

Join a dynamic Pediatric Emergency Department, providing exceptional care to children with diverse medical needs. Collaborate with a dedicated team in a supportive environment that fosters professiona...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join our dynamic team as a results-driven Account Executive, where you'll convert qualified leads into long-term customers, manage the full sales cycle, and build strong relationships with key decisio...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$235K - $300K *

Elevate your legal career by navigating complex privacy and tech regulations. Contribute your expertise to the dynamic growth of a leading ad tech firm while managing strategic legal advice, negotiati...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$70K - $153K *

Lead the charge in designing and validating Layer 1 fiber paths, ensuring accurate circuit provisioning and troubleshooting across the OSI model. Collaborate with vendors and field engineers to delive...

US-AnywhereRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $110K *

Lead the charge in overseeing complex clinical trials, ensuring timely execution and adherence to budget. Drive collaboration across teams while maintaining high standards for project delivery and sta...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $125K *

Contribute to our growing operations team by supporting diverse tasks across finance, HR, IT, and compliance, while driving process improvements and project initiatives that enhance organizational eff...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Transform revenue accounting and reporting by leading complex analyses, ensuring compliance with GAAP and FERC, and developing automated solutions. Collaborate across teams to enhance data accuracy an...

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$66K - $182K *

Unlock potential by joining a collaborative team dedicated to delivering exceptional accounting and consulting services to Tribal governments, enhancing client relationships and driving impactful solu...

US-AnywhereRemote

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$67K - $165K *

Pioneer contract negotiations and provider relationships, driving value-based agreements and network expansion. Collaborate cross-functionally to enhance performance and achieve financial goals while...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Empower your career by leading a dynamic engineering team to enhance in-house ERP applications. Drive technical direction, mentor talent, and ensure optimal performance while collaborating with stakeh...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$99K - $232K *

Drive clinical operations transformation by leading teams in health services, optimizing workflows, and implementing innovative solutions to enhance provider performance and service delivery across mu...

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$163K - $220K *

Transform vendor strategies and cost management across the organization. Drive financial performance with analytics, lead sourcing events, and collaborate with cross-functional teams to optimize value...

US-AnywhereRemote

Reposted today

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$140K - $180K *

Transform growth trajectories for high-value clients by executing account strategies, leading contract renewals, and cultivating executive relationships while driving data-informed decisions that enha...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Elevate workforce management by leading forecasting, capacity planning, and real-time optimization across teams and BPO partners. Drive efficiency and performance using data and technology while devel...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Unlock potential by strategizing and cultivating long-term partnerships with leading pharmaceutical manufacturers, driving customer success and expanding offerings through innovative engagement and va...

US-AnywhereRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Engage with cross-functional teams to improve revenue cycle operations by identifying inefficiencies, deploying analytical solutions, and enhancing workflows to maximize revenue and streamline process...

US-AnywhereRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$126K - $148K *

Contribute to effective primary care by managing patients' health needs, ensuring coordinated care across teams, and fostering lasting relationships aimed at improving patient outcomes within a value...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$88K - $105K *

Oversee and enhance compensation programs, ensuring data-driven application and compliance. Partner with HR and business leaders to deliver equitable job evaluation, design, and analysis aligned with...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Transportation

$146K - $215K *

Elevate supplier performance by leading a team focused on manufacturing excellence, capacity readiness, and strategic improvement initiatives to support business growth and operational maturity across...

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.