Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

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$130K - $140K *

Partner with us to reshape enterprise solutions in education, driving impactful partnerships and strategic transformations across organizations. Your leadership will elevate educational outcomes for e...

US-AnywhereRemote

3 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Empower the future of telehealth by managing and negotiating payer contracts, collaborating with cross-functional teams, and ensuring compliance with healthcare reimbursement standards for optimal org...

US-AnywhereRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$137K - $221K *

Optimize compliance in a fast-paced, remote legal environment by managing ethics in litigation, from intake through settlement, while collaborating with attorneys and staff to ensure robust compliance...

US-AnywhereRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$80K - $95K *

Transform the landscape of connectivity by managing sales for multiple MDU communities. Drive results through data analysis, strategic marketing, and strong partnerships with property professionals an...

2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$99K - $125K *

Drive HR and safety initiatives while overseeing compliance and risk management. Lead a team to enhance employee wellness and operational efficiency, ensuring alignment with agency goals and fostering...

2 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$63K - $101K *

Optimize compliance in Interventional Radiology charge capture by conducting audits, educating teams, and enhancing coding practices. Collaborate with clinical departments to identify and rectify codi...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $155K *

Drive creative excellence as a key leader, managing cross-functional teams to deliver innovative solutions and strategic insights while nurturing client relationships and maintaining high creative sta...

US-AnywhereRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$152K - $190K *

Shape the future of IoT by driving complex sales to mid-sized customers, forging impactful relationships, and leading the charge in the digital transformation of essential industries. Enjoy a fully re...

US-AnywhereRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$220K - $240K *

Drive enterprise growth by acquiring new logos and building strong relationships in a collaborative, fast-paced environment. Leverage strategic prospecting to engage insights and R&D leaders while nav...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$200K - $275K *

Deliver innovative solutions for complex enterprise environments by engaging executive stakeholders, navigating long sales cycles, and driving transformational software deals that enhance infrastructu...

US-AnywhereRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$69K - $104K *

Drive logistics excellence by coordinating transportation and optimizing supply chain operations. Collaborate with cross-functional teams to ensure timely deliveries, manage costs, and enhance service...

Today

  •   Less than 5 years exp.  •   Business Services

$107K - $147K *

Unlock potential by ensuring accurate and timely external financial reporting. Collaborate with cross-functional teams to enhance compliance and operational efficiency while driving continuous improve...

US-AnywhereRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$78K - $156K *

Join a team that's dedicated to enhancing business systems through design, configuration, and support. As a Senior Application Analyst, you'll lead improvements, mentor junior analysts, and ensure sea...

US-AnywhereRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$78K - $156K *

Manage system design, enhancements, and support as a Senior Application Analyst. Collaborate with stakeholders, mentor junior team members, and improve workflows while ensuring application performance...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$78K - $156K *

Unlock your potential with this role, focusing on business systems design, enhancements, and cross-team collaboration to elevate technology platforms. Guide and support junior analysts while driving i...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $190K *

Drive the design and operation of robust AI systems, leading technical delivery and guiding teams in building high-throughput pipelines and production services that enhance customer engagement across...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$130K - $190K *

Shape the future of AI by building scalable AI agents that drive innovation across healthcare applications, fostering collaboration with diverse teams to implement advanced solutions and ensure operat...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$173K - $245K *

Unlock insights through data analytics and experimentation to enhance credit risk management. Collaborate with cross-functional teams to optimize policies, monitor performance, and drive strategic gro...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $150K *

Engage with Fortune 500 brands to drive enterprise solutions. As a seasoned seller, navigate complex sales cycles, and deliver value through Rasa’s AI offerings, while cultivating key stakeholder rela...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $144K *

Elevate our IT team by leading the development of Robotic Process Automation solutions. Collaborate with peers to drive automation and AI initiatives, ensuring successful implementation and optimizati...

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$132K - $193K *

Unlock potential by leading the enterprise employee listening strategy, enhancing assessment science, and applying analytics to drive data-informed talent decisions. Collaborate with cross-functional...

US-AnywhereRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$105K - $150K *

Drive customer engagement by reactivating interest in modern security solutions. Leverage existing relationships to build trust, deliver tailored presentations, and cultivate new business opportunitie...

5 days ago

  •   Less than 5 years exp.  •   Business Services

$88K - $149K *

Join a dynamic team in evaluating medication prior authorizations while developing clinical criteria and working closely with healthcare providers to ensure quality patient care through evidence-based...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$105K - $120K *

Join a dynamic team as you lead integrated media strategy and client relationships in programmatic advertising. Drive innovation, mentor talent, and collaborate cross-functionally to achieve strategic...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$90K - $95K *

Manage the end-to-end startup of new accounts, driving operational excellence through strategic planning, training, and performance evaluation while collaborating with local teams to ensure seamless o...

4 days ago

  •   5 - 7 years exp.  •   Staffing

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.