Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

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$79K - $118K *

Elevate patient care by engaging in evidence-based practices and multidisciplinary collaboration. Utilize your clinical expertise to assess and implement care plans while fostering safety and communic...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $118K *

Accelerate your career by delivering exemplary patient care and collaborating with a dynamic healthcare team. Engage in quality initiatives, uphold safety standards, and enhance patient outcomes in a...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$129K - $232K *

Drive innovative financial stewardship by managing vendor funding to maximize strategic value. Collaborate across various stakeholders to ensure prudent allocation, optimize resources, and deliver eff...

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$300K *

Manage the complete sales cycle by identifying leads, building relationships, and closing deals efficiently while collaborating with cross-functional teams to enhance customer success and drive the ad...

US-AnywhereRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Optimize our internal IT systems and security posture while managing user access, supporting AWS operations, and ensuring compliance. Collaborate with the COO to enhance efficiency and maintain a secu...

US-AnywhereRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$227K - $338K *

Shape the future of enterprise applications by leading strategy, optimizing delivery, and fostering collaboration across global teams. Drive digital transformation and AI integration to enhance busine...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$72K - $89K *

Join our team to optimize pricing strategies and enhance deal structures. Collaborate with multiple stakeholders to achieve competitive quotes and maintain target margins while supporting sales initia...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$138K - $172K *

Empower revenue teams as a Senior Business Systems Analyst, driving efficiency through Salesforce architecture, process design, and actionable data across GTM, Marketing, Sales, and Customer Success o...

US-AnywhereRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $110K *

Empower your career by driving strategic sales growth and customer relationships across the retail market segment. Leverage your expertise to identify business opportunities and enhance Clean Harbors...

4 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$100K - $120K *

Pioneer innovative cloud solutions by automating and optimizing deployment processes as a key member of a dynamic team focused on enhancing software delivery and infrastructure reliability in a fast-p...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$98K - $116K *

Shape the future of student success by leading innovative career development initiatives. Collaborate with faculty, industry leaders, and alumni to enhance experiential learning and create pathways fo...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $148K *

Advance your career by leading a dynamic proposal management team, orchestrating RFP projects to drive business growth and operational excellence. Collaborate with experts, enhance proposal quality, a...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $190K *

Create a robust People function by designing leveling frameworks, enhancing management development programs, and establishing a clear compensation philosophy. Partner with managers to elevate performa...

US-AnywhereRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$75K - $95K *

Empower customer success through strategic account management and relationship building. Collaborate closely with clients to ensure satisfaction and retention, while driving revenue and addressing uni...

US-AnywhereRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$85K - $92K *

Partner with us to cultivate and manage relationships with mid-level donors, enhancing their engagement and increasing donations, while contributing to overall revenue goals through strategic outreach...

US-AnywhereRemote

4 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$118K - $195K *

Shape enterprise sourcing strategies for indirect spend, optimizing supplier partnerships and driving operational efficiencies across multi-site environments. Lead a dedicated team to deliver cost sav...

US-AnywhereRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$73K - $110K *

Champion a patient-centered approach in pain management, supporting interventional therapies and office operations. Collaborate with specialists to ensure safe and effective procedures, enhancing pati...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Elevate operational efficiency by leading shared service improvements and cross-functional collaboration to enhance patient and provider experiences while driving team performance and process excellen...

US-AnywhereRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$96K - $132K *

Unlock potential by leading global sourcing strategies that align with business objectives. Drive supplier relationships, negotiate contracts, and develop sourcing plans to optimize supply chain effic...

Reposted yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Empower our mission by leading IT audits that assess risk and enhance controls. Collaborate across teams to ensure compliance and operational effectiveness while mentoring fellow auditors and deliveri...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $92K *

Drive the resolution of technical support escalations as a key Tier 2 expert, leveraging your skills to troubleshoot issues, foster collaboration within teams, and enhance workflows in a dynamic envir...

US-AnywhereRemote

4 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$125K - $167K *

Empower platform resilience and reliability as a technical lead, overseeing automation, incident management, and performance improvements for enterprise-scale container platforms. Collaborate across t...

4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$200K *

Drive impactful student journeys as a Senior Account Executive, guiding families through the admissions process. Leverage your sales expertise to foster relationships, exceed targets, and enhance our...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Unlock potential by leading construction projects from concept to completion. As a Project Manager, you'll ensure customer satisfaction and project performance while managing design, scheduling, and q...

6 days ago

  •   Less than 5 years exp.  •   Technical Services

$70K - $156K *

Champion operational excellence by leading loan documentation support and guiding team members in a high-energy remote environment. Drive innovation and client satisfaction within Commercial Lending O...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.