Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

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$79K - $118K *

Join our dynamic Emergency Department team, providing critical care and support to patients of all ages. Utilize your nursing expertise in a fast-paced environment, ensuring safe and effective treatme...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Unlock potential by driving sales growth in railing materials. Leverage existing customer relationships while targeting new accounts in your territory. This role requires strong market knowledge and s...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Transform clinical trial expertise into impactful project delivery. Oversee research integrity, lead cross-functional teams, and promote operational excellence to ensure successful trial execution wit...

US-AnywhereRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Elevate your career as you engage with clients, document processes, and support Salesforce solutions for federal initiatives, ensuring alignment with operational needs and delivering comprehensive bus...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$200K - $250K *

Drive sales growth by acquiring new accounts in cybersecurity technology while building strong customer relationships and ensuring satisfaction. Collaborate with Channel Partners to exceed sales quota...

US-AnywhereRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$79K - $118K *

Unlock potential by delivering compassionate, evidence-based nursing care while collaborating with a dynamic healthcare team to enhance patient outcomes in a fast-paced maternity unit...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Shape the future of client partnerships by overseeing account management, driving strategic insights, and fostering strong relationships. Collaborate with cross-functional teams to fuel growth and ens...

US-AnywhereRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$79K - $118K *

Join our dynamic Medical ICU team to deliver high-acuity patient care, enhance outcomes, and collaborate with specialists. Embrace innovation and teamwork in a supportive environment focused on excell...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Elevate your Paid Social expertise by driving full-funnel strategies across platforms like Meta and TikTok. Utilize data-driven insights to optimize and scale campaigns while collaborating with cross...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Media

$76K - $102K *

Engage in a dynamic role driving client acquisition in the Home-Based Care sector. You'll build a robust pipeline, execute sales strategies, and collaborate cross-functionally to enhance client experi...

US-AnywhereRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$79K - $118K *

Join a team that's dedicated to delivering exceptional critical care by enhancing your clinical skills in a dynamic float pool environment. Collaborate with diverse teams across inpatient units in a r...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $118K *

Join our team to provide essential nursing care, collaborating with healthcare professionals to enhance patient outcomes and uphold safety standards in a dynamic maternity unit, while advancing your p...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Engage with customers and partners, driving sales success through relationship building, strategic planning, and market insight. Leverage your expertise in account management to consistently surpass s...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$115K - $140K *

Unlock your potential in a dynamic support role, resolving technical issues and enhancing integrations. Collaborate with teams to improve workflows and deliver exceptional service, while leveraging yo...

US-AnywhereRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$85K - $120K *

Collaborate with Sales RVPs to implement strategic selling programs, delivering tailored presentations and support for mid-market opportunities while managing resources and enhancing client engagement...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$128K - $158K *

Drive growth in vocational Class 8 truck markets by supporting corporate sales, enhancing dealer relationships, and collaborating with bodybuilders. Your expertise will shape product offerings and boo...

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$105K - $125K *

Collaborate with strategic partners to drive growth initiatives, strengthen relationships, and enhance market presence. This role focuses on building executive connections, managing partner performanc...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$61K - $122K *

Transform cancer diagnostics by configuring and improving business systems. Collaborate cross-functionally to enhance technology platforms, ensuring user support and optimizing workflows to drive effe...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Reimagine client partnerships by managing complex relationships, driving performance, and leading recovery strategies. Collaborate with executives to ensure client success and identify growth opportun...

US-AnywhereRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$155K - $205K *

Unlock client advocacy by leading a transformative client experience function. Drive strategy, manage escalations, and enhance satisfaction across all case phases, ensuring clients feel valued and hea...

US-AnywhereRemote

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$150K - $170K *

Drive strategic excellence in sponsor operations, ensuring high-quality project delivery and alignment across enterprise programs. Manage a team of leaders to foster innovation and optimize operationa...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Shape the HR function of a dynamic healthcare organization, overseeing recruitment, culture, and compliance while advising leadership on strategic people initiatives to attract and retain top talent i...

US-AnywhereRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $130K *

Join a team that's driving innovation in Oracle Cloud Financials. Collaborate with clients and technical teams to design solutions, execute configurations, and support end-users, all while enhancing y...

US-AnywhereRemote

4 days ago

  •   Less than 5 years exp.  •   Business Services

$110K - $143K *

Elevate your career by implementing and supporting integration solutions, collaborating with stakeholders, and leveraging cutting-edge technology to enhance healthcare interoperability and system conn...

US-AnywhereRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Optimize automated systems by troubleshooting and enhancing control processes. Collaborate with a skilled team to ensure operational excellence and reliability in material handling equipment for a lea...

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.