Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$57K - $107K *

Drive business growth by establishing strong client relationships and executing effective sales strategies in a competitive environment. Engage clients to tailor solutions, meet sales targets, and enh...

4 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$91K - $137K *

Advance quality patient care by leading endoscopy services, ensuring compliance with standards, and fostering a collaborative team environment. Utilize your nursing expertise to enhance operational ef...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $118K *

Join a team that's dedicated to delivering exceptional patient care through evidence-based practices and collaboration, while fostering a culture of safety and professional growth in a dynamic nursing...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $90K *

Champion project excellence by stabilizing operations, ensuring quality assurance, and enhancing training across workforce services. Engage directly with teams to improve performance, compliance, and...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Lead the development and management of district-wide compensation programs, ensuring alignment with strategic goals. Oversee job classification, salary structures, and compliance with regulations whil...

6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $175K *

Transform client relationships by driving value and engagement in a fast-growing segment. Leverage product expertise to manage renewals and upsell opportunities while contributing to best practices wi...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$121K - $161K *

Transform your career by leading the design and implementation of Veeva Vault RIM, ensuring optimal performance and compliance while collaborating with cross-functional teams to enhance user experienc...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $174K *

Lead the full enterprise sales cycle, engaging with C-suite stakeholders and driving strategic partnerships in WealthTech. Leverage relationships to overcome complex business challenges and deliver me...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$85K - $100K *

Advance your career by supporting construction project teams through financial analysis, budget reporting, and performance tracking. Collaborate with internal and external stakeholders to ensure proje...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$118K - $186K *

Drive impactful legal defense by managing insurance litigation, preparing briefs, and leading trials in Virginia courts. Utilize your expertise to support clients and colleagues through clear document...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$71K - $91K *

Join a team that's dedicated to optimizing Workday HCM systems. You will facilitate collaborations, enhance data integrity, administer functionality, and drive operational efficiencies through system...

US-AnywhereRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Lead the charge in driving self-serve growth for a cutting-edge AI product, optimizing acquisition channels and enhancing user engagement for small and medium-sized businesses. Shape strategies that e...

US-AnywhereRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$73K - $110K *

Lead the charge in delivering comprehensive nursing care, employing evidence-based practices and collaborating within a dynamic team to enhance patient outcomes and safety across the healthcare contin...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $110K *

Collaborate with the care team to optimize patient outcomes through evidence-based nursing practices, effective communication, and continuous evaluation of care processes in a dynamic, supportive envi...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$91K - $137K *

Drive your career forward by leading patient flow and supervising advanced procedures in a dynamic medical imaging environment. Collaborate with a skilled team to enhance departmental efficiency and e...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$158K - $205K *

Unlock your potential as a strategic partner, driving business analysis and technology solutions to enhance operational efficiency and support digital transformation initiatives across enterprise plat...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Drive impactful data visualization initiatives by collaborating with clinical and operations leaders. Leverage BI tools to create insightful content, mentor team members, and ensure data governance fo...

US-AnywhereRemote

6 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$120K - $140K *

Champion growth by managing strategic accounts with Walmart and Sam's Club, executing impactful business plans, and fostering collaboration across cross-functional teams to maximize market share and p...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$100K - $125K *

Join our dynamic team to develop innovative sourcing strategies, lead supplier negotiations, and drive value creation within the Americas, contributing significantly to our growth and sustainability g...

US-AnywhereRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Help us build a robust IT infrastructure for a leading pharmaceutical company. Join our dynamic team of Server Engineers, working onsite to support and enhance systems in QC Labs through innovative so...

3 weeks ago

  •   5 - 7 years exp.  •   Staffing

$100K - $120K *

Join a team that's dedicated to optimizing our hiring processes by creating robust systems, ensuring data integrity, and enhancing the overall talent acquisition experience while driving consistent re...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$79K - $118K *

Join our dynamic Emergency Department team, providing critical care and support to patients of all ages. Utilize your nursing expertise in a fast-paced environment, ensuring safe and effective treatme...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Unlock potential by driving sales growth in railing materials. Leverage existing customer relationships while targeting new accounts in your territory. This role requires strong market knowledge and s...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Transform clinical trial expertise into impactful project delivery. Oversee research integrity, lead cross-functional teams, and promote operational excellence to ensure successful trial execution wit...

US-AnywhereRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Elevate your career as you engage with clients, document processes, and support Salesforce solutions for federal initiatives, ensuring alignment with operational needs and delivering comprehensive bus...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.