Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

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$91K - $137K *

Grow your career with this leadership role in clinical trials, overseeing regulatory compliance and ensuring adherence to standards. Your expertise will guide a team in managing submissions and audits...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$165K - $295K *

Champion the evolution of contingent workforce strategy and governance, overseeing compliance and optimization. Collaborate across functions to manage costs and enhance program efficiency, ensuring a...

3 weeks ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$88K - $105K *

Join a dynamic team driving HR excellence by partnering with leadership to enhance talent, culture, and performance. Utilize data-driven insights and HR expertise to align organizational priorities an...

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$95K - $206K *

Join a dynamic team as a Clinician Player Coach, mentoring peers while delivering high-quality in-home evaluations. Balance clinical duties with mentorship, ensuring exceptional care and support for n...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $216K *

Champion a high-performing Employee Relations team, delivering strategic support on workplace issues, ensuring consistent guidance, and driving effective risk management across the organization while...

US-AnywhereRemote

Today

  •   8 - 10 years exp.  •   Business Services

$136K - $253K *

Transform revenue growth by driving sales of partnership products to Mid Law High Value Accounts. Collaborate with territory owners and manage complex sales cycles while leveraging deep product knowle...

US-AnywhereRemote

4 days ago

  •   Less than 5 years exp.  •   Media

$74K - $95K *

Elevate brand strategy by analyzing market trends and customer behavior. Collaborate on marketing initiatives, develop targeted messaging, and manage projects to enhance brand appeal and customer expe...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$104K *

Lead complex procurement sourcing initiatives, driving cost reduction and vendor engagement with cross-functional teams to achieve business objectives and enhance operational efficiency...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$205K - $242K *

Shape the future of internal communications by leading the strategy for People Success, crafting clear, impactful messaging for organizational changes, and enhancing engagement across the workforce th...

US-AnywhereRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$155K - $190K *

Elevate communications strategy for product launches and partnerships, translating technical concepts into compelling narratives that highlight our corporate story and engage priority audiences effect...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$114K - $171K *

Lead the charge in delivering exceptional pharmaceutical care across community and specialty pharmacy sites. Collaborate with healthcare teams to optimize medication therapy and ensure patient safety...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$116K - $171K *

Empower the future of talent acquisition by designing and optimizing technology solutions that streamline the recruit-to-hire lifecycle, ensuring user-friendly experiences while collaborating with div...

US-AnywhereRemote

4 weeks ago

  •   5 - 7 years exp.  •   Transportation

$125K - $133K *

Lead the development and implementation of Generative AI solutions to enhance internal tooling and products. Collaborate with teams to refine engineering practices, driving AI adoption and ensuring st...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Champion quality assurance by applying engineering principles to enhance production processes and efficiency, while collaborating with cross-functional teams to establish standards and validate adhere...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$75K - $95K *

Optimize project outcomes by managing strategy and team engagement. Drive financial control and coordination of tasks to ensure timely delivery of high-quality results across print and digital channel...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K *

Join a team that's driving growth by managing key Integrator accounts, developing sales strategies, and fostering relationships to exceed corporate goals in the material handling industry...

US-AnywhereRemote

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$114K - $171K *

Unlock potential by overseeing pharmaceutical care, providing patient education, and collaborating with healthcare teams to ensure safe medication practices across community and specialty pharmacy sit...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$60K - $119K *

Drive impactful clinical research by leading site contract negotiations and execution. Collaborate with global teams to ensure compliance and efficiency in clinical trial agreements, balancing timelin...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $135K *

Join a dynamic team to optimize global hiring outcomes by delivering a seamless full lifecycle recruiting experience. Partner with leaders and enhance talent strategies to attract top candidates acros...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Accelerate program implementation and stakeholder engagement in pharmaceutical market access. Oversee daily operations, client relations, and staff management while ensuring adherence to budgets and p...

US-AnywhereRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$102K - $147K *

Join a dynamic team to drive client growth and retention, forging strong relationships with C-Level executives in the Large Enterprise segment, and ensuring optimum value from services provided while...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$100K - $192K *

Join a team that's driving innovative healthcare solutions by developing key relationships with health systems. This role involves pipeline management, strategic engagement, and collaborative solution...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $192K *

Shape the future of healthcare by developing key relationships with health system accounts. Utilize your sales acumen to navigate complex organizational structures, identify opportunities, and deliver...

US-AnywhereRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Shape your career by leading plant marketing initiatives, driving new business, and collaborating with management to achieve strategic goals while fostering a high-performance team culture...

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$86K - $91K *

Lead the People Operations function, driving employee relations, compliance, and engagement initiatives across the U.S. and Canada. Collaborate with leadership to enhance policies and processes while...

US-AnywhereRemote

3 days ago

  •   5 - 7 years exp.  •   Transportation

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.