Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$175K - $210K *

Lead a dynamic team to drive presales and solution architecture for enterprise transformation, shaping innovative technology solutions and enhancing client engagements while fostering a high-performin...

RemoteRemote

6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Engage in a pivotal leadership role to define and execute US pre-launch strategies for innovative oncology products, influencing global decisions and aligning stakeholders to drive successful market r...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$113K - $170K *

Join a team that's driving innovation in financial services by leading product initiatives, optimizing processes, and collaborating across departments to enhance product delivery and performance. Your...

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$122K - $212K *

Join a team that's transforming enterprise contracting through AI-enabled solutions. Lead value realization efforts, ensuring measurable outcomes and strategic alignment across finance, operations, an...

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$200K - $300K *

Shape the future of electron microscopy technologies by driving strategic growth, optimizing P&L performance, and leading a high-performing team to deliver exceptional results and market expansion...

Reposted 2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$96K - $210K *

Lead personalized financial planning for senior executives, integrating workplace benefits into comprehensive strategies. Drive client engagement and satisfaction while managing relationships and expa...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Engineer innovative data products that empower global businesses. Lead cross-functional teams to define product strategy, manage lifecycles, and drive performance metrics, ensuring alignment with mark...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$170K - $200K *

Drive transformative initiatives that enhance business growth and efficiency. Collaborate with senior leaders to identify high-impact opportunities, orchestrate cross-functional teams, and implement i...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$85K - $98K *

Transform client relationships by owning a portfolio of B2B accounts, driving growth through tailored solutions in FX and payments, and leveraging technology for impactful service delivery...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$154K - $204K *

Champion strategic financial planning and analysis, driving enterprise-wide initiatives and insights. Lead a high-performing team, enhance reporting capabilities, and support executive decision-making...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$90K - $110K *

Elevate your career by driving growth in Instrumentation Services. Identify new opportunities, expand complex account relationships, and collaborate with teams to deliver strategic solutions that achi...

1 week ago

  •   Less than 5 years exp.  •   Staffing

$119K - $155K *

Shape the future of enterprise sales by driving growth and cultivating long-term relationships. Manage complex sales cycles and leverage AI tools to optimize efficiency and insights, ensuring customer...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$187K - $234K *

Drive the future of patient care by leading product strategy across Virtual Pharmacy, Patient App, and Partnerships. Shape high-impact initiatives, mentor teams, and enhance operational excellence thr...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$156K - $234K *

Join a dynamic team to lead the development of AI-driven customer success platforms, enhancing post-sale experiences through innovative technology and automation, while collaborating closely with engi...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$177K - $301K *

Develop and lead strategic client growth initiatives, fostering executive relationships and aligning teams to drive long-term value, retention, and measurable outcomes across a portfolio of enterprise...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$150K - $180K *

Shape the future of financial partnerships by driving revenue through strategic alliances with banks and fintechs. Collaborate cross-functionally to enhance Socure's market presence and ensure seamles...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$130K - $160K *

Empower operational excellence across a portfolio of surgical centers. Drive strategic growth, enhance performance, and foster physician partnerships while ensuring compliance and quality standards ar...

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Accelerate sales growth by managing hardware and service functions across a designated territory. Drive project management and customer relationships to meet revenue and profitability goals while ensu...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$80K - $95K *

Drive supply chain efficiency as a Senior Buyer, collaborating with cross-functional teams to optimize supplier partnerships, manage purchase orders, and ensure timely delivery of high-quality medical...

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$128K - $252K *

Lead the charge in building and managing high-performing software engineering teams. Drive innovation, optimize processes, and deliver high-quality applications while fostering a culture of excellence...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $200K *

Drive growth and innovation by leading commercial strategies in the Media, Entertainment, and Gaming sectors. Collaborate with teams to enhance client relationships, identify new opportunities, and en...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Media

$118K - $178K *

Shape strategic initiatives by leading key deliverables and financial analyses. Collaborate with partners to enhance business processes and drive impactful recommendations, ensuring alignment and time...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$126K - $154K *

Help us shape the future of client training and adoption in healthcare technology. This role leads the design and delivery of impactful training programs, ensuring clients achieve operational excellen...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$180K - $215K *

Unlock potential by leading regional sales efforts for a groundbreaking product. Drive performance through strategic execution, team leadership, and customer engagement in a fast-paced, entrepreneuria...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Manage the Financial Advocacy department, ensuring efficient operations and compliance with regulations. Lead coaching, development, and performance management while implementing strategies to minimiz...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.