Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$150K - $180K *

Empower a high-performing sales team to drive strategic growth and customer engagement in the biopharma sector. Lead complex sales initiatives, build executive relationships, and translate business st...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Transform regional sales strategies in Interventional Oncology, driving growth and talent development. Lead a high-performing team, manage budgets, and build key relationships to enhance market penetr...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$169K - $255K *

Shape the future of personalized consumer products by driving strategic partnerships and revenue growth. Lead business development efforts, cultivate relationships, and expand market reach to position...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$169K - $255K *

Join a team that's driving growth through strategic partnerships in personalized consumer products. Lead initiatives to expand market reach and revenue streams while collaborating across functions to...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Transform your career by leading diverse contracted services, driving operational excellence, and fostering client relationships to achieve financial goals and enhance customer satisfaction in a dynam...

1 week ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$90K - $110K *

Lead a dynamic team to optimize food and nutrition services, ensuring operational excellence and client satisfaction while managing a budget of $2-15M+. Drive service improvements and compliance in a...

2 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$100K - $120K *

Take ownership of multiple contracted services, managing operations and client relationships to achieve financial goals and enhance customer satisfaction. Lead a team to deliver exceptional service wh...

2 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$175K - $190K *

Engage with us to lead and optimize Gaming Operations, ensuring compliance and fostering team relations while managing security, surveillance, and facilities for a dynamic environment...

2 weeks ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$190K - $381K *

Empower global partnerships by leading strategy and execution across markets, enhancing relationships with key partners, and driving innovation in financial services. Build a high-performing team to s...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$150K - $180K *

Lead national physician engagement and business development for a fertility pharmacy, managing a multi-layered team to drive growth and build executive relationships across clinics and provider networ...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Innovate product management across a diverse SaaS portfolio, leading teams to enhance strategy and execution. Collaborate with executives to drive growth and operational excellence in global markets...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$140K *

Shape the future of public safety SaaS by leading a high-performing sales team, driving growth, and executing strategic initiatives in a rapidly evolving market. Collaborate cross-functionally to enha...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Optimize operational performance across multiple remote locations. Lead strategic initiatives to enhance productivity, quality, and service. Collaborate with cross-functional teams to drive continuous...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Transform operational excellence across multiple remote locations by leading strategic initiatives, enhancing productivity, and driving continuous improvement in service quality and performance metric...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Shape operational excellence across multiple remote locations by leading strategic initiatives, optimizing performance, and driving continuous improvement in service, productivity, and quality. Collab...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $150K *

Join a team that's shaping high-impact strategies and narratives for enterprise growth. Collaborate with senior leaders to craft compelling pitches and support organic initiatives, driving success acr...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join a dynamic team to lead specialized logistics, overseeing complex freight operations from planning to delivery while driving sales and supporting your team in a player-coach capacity...

6 days ago

  •   5 - 7 years exp.  •   Transportation

$160K - $180K *

Lead strategic health plan implementations and optimize client solutions. Drive cross-functional collaboration, manage complex projects, and enhance operational workflows to ensure successful launches...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$200K - $205K *

Join a team that's redefining enterprise sales by leading a diverse group of sellers to exceed quotas, drive growth, and implement innovative fraud solutions in a rapidly evolving market...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $120K *

Shape the future of Crop Protection & Chemicals by driving sales and fostering client relationships. Utilize strategic insights and collaboration to achieve targets and expand market presence while ma...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Drive efficient order management and logistics operations, ensuring compliance with pharmaceutical regulations while collaborating with internal teams and 3PL partners to optimize product flow and per...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$175K - $205K *

Transform client relationships and drive growth by leading strategic initiatives in scientific visualization, medical education, and digital engagement. Manage multidisciplinary teams and oversee acco...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $200K *

Empower global Salesforce capabilities by leading a dynamic team to drive innovative solutions. Collaborate with stakeholders to align projects with business goals, ensuring effective delivery and man...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$85K - $100K *

Drive operational excellence by managing production, safety, and workforce development in a dynamic manufacturing environment. Lead teams to achieve production goals while ensuring compliance with saf...

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$186K - $234K *

Grow your career by driving sales and building relationships in the neurology and rare disease sectors. Collaborate with healthcare professionals to enhance patient care and achieve sales targets whil...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.