Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$110K - $130K *

Join a team that's driving organizational excellence by translating business strategy into innovative HR solutions. You'll lead talent management, employee relations, and engagement initiatives while...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$122K - $183K *

Design the future of critical care by providing expert intensivist services, overseeing patient care, collaborating with multidisciplinary teams, and continuously improving healthcare outcomes in a fa...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Empower your career by leveraging machine learning to enhance business efficiency. Collaborate with cross-functional teams to develop and deploy impactful models, driving revenue growth and optimizing...

US-AnywhereRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$127K - $187K *

Unlock potential by transforming data into actionable insights that drive strategic decisions in communications. Collaborate across teams to enhance measurement frameworks and reporting, ensuring impa...

US-AnywhereRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in process improvement and compliance consulting, driving operational efficiency and risk management across diverse industries. Collaborate with stakeholders to assess workflows, ident...

Today

  •   8 - 10 years exp.  •   Business Services

$95K - $118K *

Join a dynamic team as you drive supplier performance in the Thermal Management segment, ensuring quality and efficiency across the supply chain while collaborating globally to elevate strategic purch...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$96K - $148K *

Lead the charge in designing and building secure integrations for enterprise ITSM platforms. Analyze data flows, enhance system connections, and ensure compliance while delivering resilient solutions...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$90K - $120K *

Drive sales growth by managing customer relationships and executing strategies. Assess market needs and deliver tailored solutions while coordinating with technical teams. Optimize territory managemen...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$90K - $120K *

Grow your career with a dynamic team that drives sales growth through strategic customer engagement, market analysis, and solution identification, all while ensuring exceptional customer satisfaction...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$90K - $120K *

Drive sales growth by executing strategic plans, managing customer relationships, and addressing market needs while identifying new opportunities and solutions for an automotive-focused territory. 50...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $170K *

Lead and scale a high-performing sales team, driving revenue growth and execution. Collaborate cross-functionally to enhance go-to-market strategies while coaching and developing future sales leaders...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$80K - $95K *

Accelerate audit excellence by managing financial and operational audits, ensuring efficiency and compliance while fostering continuous improvement and collaboration across teams to deliver high-quali...

US-AnywhereRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $170K *

Transform complex Federal consulting engagements by leading diverse teams, establishing strategies, and ensuring practical outcomes that enhance government capabilities and client trust...

US-AnywhereRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$110K - $130K *

Champion transformative solutions by leading client engagements focused on regulatory risk management within law firms. Elevate operational processes, mentor teams, and drive impactful change for meas...

US-AnywhereRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Shape client success by leading complex consulting projects, integrating diverse workstreams into actionable insights, and driving high-quality deliverables while fostering team growth and managing st...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$92K - $137K *

Join our team to provide leadership in nursing care, ensuring quality standards, safety, and professional development while collaborating with healthcare disciplines to foster effective patient care f...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$128K - $152K *

Lead strategic UX research initiatives, driving product discovery and user insights. Collaborate with cross-functional teams to shape product direction, enhance user experience, and integrate innovati...

US-AnywhereRemote

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Engage in high-impact medicine as a frontline Member Access Provider, initiating treatment and supporting patients in their recovery during the critical early weeks, while collaborating with a multidi...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Champion competitive pay practices by analyzing and designing compensation programs. Collaborate with HR and business leaders to enhance talent retention through equitable compensation strategies and...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$108K - $130K *

Collaborate to drive end-to-end solution delivery for major retail platforms, leading technical engagement and operational ownership while leveraging AI workflows to ensure high-quality, innovative so...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$142K - $178K *

Shape the future of technology storytelling by crafting compelling narratives that highlight innovation and AI. Collaborate with leaders to elevate Mercury's brand through integrated communications, e...

US-AnywhereRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$108K - $158K *

Drive continuous improvement initiatives by collaborating with cross-functional teams to enhance recordkeeping processes, ensuring operational efficiency and measurable outcomes through expert analysi...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$231K - $340K *

Drive strategic relationships with Federal stakeholders to expand technology solutions for VA and HHS, managing complex sales cycles and executing growth strategies for user acquisition and retention...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $98K *

Transform client relationships by owning a portfolio of B2B accounts, driving growth through tailored solutions in FX and payments, and leveraging technology for impactful service delivery...

US-AnywhereRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Join us in owning the networking hardware category to streamline innovations! You'll negotiate with OEMs, manage dual-sourcing complexities, and align buying plans with engineering roadmaps for optima...

US-AnywhereRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.