Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$155K - $175K *

Transform employee relations by leading a multi-site team, ensuring effective case resolution and compliance. Drive strategic initiatives, oversee high-risk investigations, and collaborate with legal...

5 days ago

  •   8 - 10 years exp.  •   Transportation

$109K - $174K *

Transform clinical research strategies to enhance evidence generation and dissemination for innovative orthopedic solutions, collaborating with cross-functional teams to ensure timely and compliant pr...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead global partnership strategy by negotiating key alliances, driving revenue, and scaling relationships. Build and manage a high-performing partnerships team in a dynamic environment, earning operat...

US-AnywhereRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $205K *

Join a team that's transforming payroll solutions by leading Workday Payroll implementations, optimizing processes, and mentoring junior consultants to enhance client efficiency and satisfaction...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $122K *

Champion recruitment success by partnering with managers to create effective hiring strategies and ensure a positive candidate experience while leveraging innovative sourcing technologies to attract t...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

$150K *

Drive revenue growth by building strategic partnerships in advocacy media sales. Engage with clients to develop tailored solutions, manage key relationships, and achieve defined revenue targets while...

US-AnywhereRemote

6 days ago

  •   5 - 7 years exp.  •   Media

$200K - $240K *

Transform the future of energy management by leveraging innovative software solutions to drive sales growth and sustainability outcomes for clients in both public and private sectors. Build strong rel...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$67K - $182K *

Elevate compliance standards by partnering with leadership to ensure regulatory alignment across commercial segments. Drive initiatives, mitigate risks, and foster a culture of ethics through collabor...

US-AnywhereRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$88K - $105K *

Accelerate progress at our finance team by transforming data into insights, driving strategic decisions, and enhancing business performance through collaboration and innovative financial practices...

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$79K - $118K *

Elevate your nursing career by joining a dynamic telemetry team, where you'll care for diverse patients and collaborate with specialists to enhance outcomes. Utilize your skills in a fast-paced enviro...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $110K *

Join a team that's transforming talent management by advising business leaders, optimizing staffing solutions, and advocating for employee development. You'll drive operational effectiveness while enh...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$80K - $145K *

Lead the charge in managing and delivering clinical portfolio initiatives with strong project management skills. Drive collaboration across teams, ensuring alignment to scope, timelines, and governanc...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $145K *

Manage and deliver clinical portfolio initiatives, ensuring project alignment, accountability, and stakeholder coordination while operating independently through all phases of implementation...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Engineer robust web applications by leading full stack development, optimizing backend APIs and creating high-performance front-ends. Collaborate effectively across teams while ensuring scalable archi...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Provide strategic legal counsel on subcontracting and supply chain agreements, ensuring compliance with government contracts and flow-down requirements while drafting, negotiating, and optimizing cont...

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$100K - $159K *

Transform financial planning and analysis processes by partnering with leadership, driving strategy, managing budgets, and delivering key insights for informed decision-making across corporate shared...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$88K - $105K *

Join a team that enhances digital delivery strategies across multi-discipline infrastructure projects. Collaborate with engineers and designers to streamline workflows, promote quality outcomes, and l...

US-AnywhereRemote

1 month ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Empower businesses by analyzing transaction data and crafting actionable insights. Collaborate with sales to design solutions, build prototypes, and present findings to executives, driving enterprise...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$79K - $118K *

Lead the charge in transforming advanced nursing practice, overseeing care on a dynamic inpatient unit. Empower your team and elevate patient outcomes through evidence-based strategies and collaborati...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $160K *

Lead strategic sourcing initiatives and oversee subcontract administration, driving compliance and risk management while fostering collaboration across teams to optimize procurement outcomes and enhan...

US-AnywhereRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Elevate sales performance by leading and developing an Account Executive team, driving regional pipeline, and implementing scalable sales systems while fostering a collaborative culture across the Ame...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$60K - $250K *

Drive impactful connections in healthcare by matching providers with facilities. Leverage your sales expertise to build relationships, negotiate contracts, and contribute to a rewarding mission that e...

US-AnywhereRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $100K *

Elevate your career by driving sales growth through strategic prospecting and collaboration. Leverage market knowledge and CRM tools to enhance customer relationships while managing a dynamic territor...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$162K - $211K *

Accelerate progress at the intersection of marketing and nephrology by cultivating partnerships with key opinion leaders in rare kidney diseases, driving brand engagement and strategic initiatives for...

US-AnywhereRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Empower impactful M&A initiatives by leading HR strategies, managing due diligence, and ensuring seamless integration while collaborating with global teams and driving best practices across the organi...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.