Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

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$147K - $220K *

Champion transformative health solutions by managing key client relationships, driving sales, and collaborating across teams to enhance Verily's impact in Life Sciences. Leverage expertise to unlock n...

US-AnywhereRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$114K - $171K *

Elevate enterprise clinical research financial operations by leading pre-and post-award activities, ensuring compliance, enhancing processes, and managing a high-performing team to optimize sponsor re...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Partner with us to innovate and enhance software solutions across the full product stack, collaborating with stakeholders to ensure alignment with business needs while staying current with technology...

US-AnywhereRemote

4 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$218K - $256K *

Shape the future of customer engagement by leading the design and delivery of innovative ML systems. Collaborate with cross-functional teams to enhance automation, safety, and customer experience thro...

US-AnywhereRemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$139K - $239K *

Join a team that's at the forefront of strategic sourcing, where you'll lead category management, negotiate complex contracts, and drive long-term value across multiple supplier relationships while ad...

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$79K - $118K *

Bring your expertise to a collaborative team dedicated to delivering outstanding patient care. Drive quality outcomes while providing treatment assessments and developing effective patient plans in a...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Unlock potential by bridging technical gaps in sales cycles, delivering tailored demos, and guiding prospects through evaluations. Collaborate with cross-functional teams to ensure customer success an...

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $110K *

Lead a strategic paid media approach for diverse partners, optimizing multi-channel performance and driving growth through data-driven insights, client engagement, and innovative campaign execution...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $180K *

Lead strategic account planning and execution to drive significant growth in Enterprise and Government accounts, focusing on multi-year expansions, complex negotiations, and maintaining strong relatio...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Media

$73K - $110K *

Join a team that's dedicated to delivering exceptional patient care while overseeing clinical staff in a dynamic family medicine setting. Collaborate with a diverse group of healthcare professionals t...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Unlock your potential as a strategic HR partner, driving initiatives that enhance workforce engagement and compliance in a dynamic manufacturing environment. Collaborate with leadership to achieve bus...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Empower your career by leading operational excellence in data center services. This role involves overseeing construction, mechanical support, and compliance to ensure projects are completed safely an...

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$220K - $227K *

Lead a high-performing sales team to drive growth in the biotechnology sector. Develop strategies, foster partnerships, and ensure successful product launches while mentoring team members to achieve e...

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $180K *

Lead large-scale database architecture and performance strategies, tackling complex challenges that enhance system reliability and compliance for high-velocity data environments, while mentoring other...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$79K - $118K *

Elevate patient care through dynamic nursing support, collaborating in a float pool across multiple facilities. Drive quality and safety initiatives while practicing evidence-based methodologies and f...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $118K *

Champion exceptional geriatric care by providing comprehensive nursing services, coordinating patient treatment, and ensuring a safe, therapeutic environment for older adults in a collaborative, evide...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $118K *

Inspire excellence in geriatric care by delivering compassionate, evidence-based nursing. Collaborate with a dedicated team to ensure holistic well-being and safety for older adults in a supportive en...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $140K *

Lead dynamic recruitment for lateral attorneys, shaping strategic hiring initiatives and enhancing the candidate experience while partnering with practice leaders to meet law firm needs...

3 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$160K - $220K *

Transform commercial contracting by leading negotiations and enhancing workflows. Collaborate with cross-functional teams to drive compliance and strategic outcomes, ensuring legal support scales effe...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$91K - $142K *

Lead the charge in corporate engagement and risk management, connecting Marketing & Communications with executive governance. Drive strategic narratives and oversee risk control programs, ensuring ali...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$99K - $149K *

Elevate healthcare outcomes by implementing innovative Workday solutions for clients. Collaborate within a dynamic team to ensure successful deployments tailored to customer needs, leveraging your ind...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$104K - $114K *

Unlock the potential of HR technology and analytics by enhancing processes, improving workflows, and leveraging AI tools. Help streamline reporting and support critical HR projects in a fast-paced env...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$59K - $124K *

Join a dynamic team to drive customer success and revenue growth by managing key accounts, building relationships, and delivering strategic logistics solutions that optimize global supply chains and e...

1 week ago

  •   Less than 5 years exp.  •   Transportation

$100K - $120K *

Empower Public Safety agencies by driving sales and fostering relationships across a multi-state territory. Manage the sales cycle through consultative partnerships, ensuring pipeline growth and reven...

US-AnywhereRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$40K - $175K *

Execute strategic sales initiatives in your territory, driving opportunities and fostering relationships with schools and organizations. Be a trusted advisor to athletic departments, coaches, and comm...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.