Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

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$110K - $130K *

Champion the future of brand marketing by driving strategic accounts, navigating complex sales cycles, and delivering high-impact sponsorship solutions tailored to Fortune 1000 companies, while levera...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Media

$110K - $130K *

Elevate the clinical research field by leading technical teams, managing complex studies, and ensuring compliance with regulatory guidelines while delivering statistical programming excellence...

2 weeks ago

  •   Less than 5 years exp.  •   Staffing

$95K - $110K *

Elevate your career by partnering with enterprise-level prospects, leveraging your consultative selling skills to drive revenue growth and navigate complex procurement processes for transformative dig...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$72K - $108K *

Empower your nursing career by providing exceptional patient care and collaborating with a multidisciplinary team while ensuring adherence to high standards of nursing practice and patient advocacy in...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$189K - $351K *

Engage with high-value law firms to drive strategic sales growth. Leverage AI solutions and consultative techniques to cultivate executive relationships and close complex deals, contributing to long-t...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Media

$80K - $95K *

Shape the future of sports engagement by managing the complete life-cycle of sales contracts. Collaborate with cross-functional teams to ensure compliance and efficiency, while demonstrating strong de...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$90K *

Accelerate growth by driving new business and nurturing customer relationships in a dynamic logistics environment. This role blends independent fieldwork with cross-functional collaboration, directly...

2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$54K - $155K *

Join a dynamic team as you support patients and their care teams in managing complex health needs through telephonic case management, applying clinical judgment and teamwork to enhance quality care ac...

US-AnywhereRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$54K - $116K *

Empower individuals by coordinating comprehensive care management services, ensuring optimal health outcomes through collaboration with members, providers, and community resources. Drive impactful cha...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Transform the supply chain landscape by leading procurement and subcontracting efforts, ensuring compliance with federal regulations while driving efficiency and innovation in support of critical defe...

US-AnywhereRemote

6 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$108K - $130K *

Elevate safety culture by leading HSE strategy, implementing plans, and fostering compliance across operations. Drive training and continuous improvement to reduce incidents while engaging with regula...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$110K - $130K *

Shape the future of health, safety, and environmental initiatives. Lead the development and execution of strategies that support organizational goals, ensuring compliance and promoting a proactive saf...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$79K - $118K *

Drive innovation by overseeing tech assessments, engaging with researchers, and managing commercialization strategies in a dynamic team environment. Support diverse projects and enhance outreach to se...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $118K *

Lead the charge in identifying and commercializing innovations through data analysis, engaging with inventors, and coordinating licensing efforts while managing multiple technology transfer projects a...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$193K - $228K *

Elevate your career by leading advisory coverage in technology risk and controls. Manage a high-performing team while partnering across engineering and security domains to enhance risk postures and dr...

US-AnywhereRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$145K - $185K *

Drive strategic capture efforts within the Defense Industrial Base, shaping pursuits that align with mission outcomes. Lead acquisition initiatives, engage stakeholders, and develop win strategies to...

US-AnywhereRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$75K - $90K *

Lead the charge in driving sales growth by engaging independent physician practices. Utilize your expertise in full-cycle sales to build relationships, conduct virtual demos, and collaborate with team...

US-AnywhereRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$124K - $170K *

Partner with us to drive HR strategy at our plant, enhancing talent management, employee engagement, and compliance. You'll lead core HR functions to cultivate a high-performance culture aligned with...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$108K - $130K *

Drive program delivery across multiple products, ensuring timely outcomes by managing risks, dependencies, and stakeholder priorities. Collaborate cross-functionally to maintain accurate project data...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $140K *

Make your mark at a fast-paced, high-growth organization by partnering with managers to enhance team dynamics, drive performance, and manage employee relations, while executing people programs and pro...

US-AnywhereRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $140K *

Play a key role in leading complex analytical projects, driving Federal transformation engagements, and delivering client-ready solutions while collaborating with stakeholders across various disciplin...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$79K - $118K *

Transform patient care by leading clinical assignments and ensuring quality outcomes. Collaborate with healthcare teams to assess and implement patient-centric strategies, enhancing the overall health...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Help us guide clients through unclaimed property compliance, reducing risks and liabilities. Leverage your analytical skills and client-facing expertise to deliver impactful solutions on state require...

US-AnywhereRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$180K - $220K *

Shape the future of legal operations by building a cutting-edge, AI-driven legal function. Collaborate across teams, manage contract lifecycles, and lead high-stakes legal work for a fast-growing SaaS...

US-AnywhereRemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Empower your career by bridging sales and engineering as a key technical resource. You'll scope, quote, and support customer needs for low and medium-voltage switchgear solutions, ensuring alignment w...

US-AnywhereRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.