Explore $100K+ Jobs in California

Discover professional opportunities across California with Ladders. From established business centers to growing regional economies, the state offers senior-level roles in technology, healthcare, finance, entertainment, manufacturing, and more. Browse vetted job listings with salaries of $100,000 or higher and find positions that align with your experience and career goals.

California industries and career opportunities

California’s diverse economy supports leadership and specialized roles at companies of all sizes. Depending on your background, you may find opportunities in software and technology, life sciences, healthcare, financial services, clean energy, media, aerospace, and professional services. Job availability and compensation vary by role, employer, and location.

Find jobs throughout the state

Explore openings in major employment centers such as Los Angeles, San Francisco, San Diego, San Jose, Sacramento, and surrounding communities. Listings may include on-site, hybrid, and remote arrangements; review each posting for its work location and requirements.

Search with Ladders

Use Ladders to focus your search on vetted professional jobs paying $100,000 or more. Review role responsibilities, qualifications, compensation details, and workplace expectations, then apply directly to opportunities that fit your goals. Keep your profile and resume current so employers can better understand your experience.

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1,000+

Jobs in California

Average Salary in USD

Average Salary: $142,597

Sort By: Relevance

$150K - $180K *

Elevate AI experiences from concept to value by collaborating with engineering and design teams. Drive strategy, build prototypes, and make data-driven decisions to enhance user engagement and product...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$300K - $350K *

Elevate your career by joining a dynamic team focused on delivering exceptional patient care. Collaborate with skilled professionals in a supportive environment that values teamwork, wellness, and con...

Today

  •   Less than 5 years exp.  •   Healthcare

$147K - $178K *

Advance your career by driving demand for innovative mental health treatments. Engage with healthcare providers and community centers to enhance patient care through impactful scientific dialogue and...

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Transform client relationships by driving business growth, securing profitable projects, and leveraging market access expertise. Lead teams to exceed expectations while identifying industry trends and...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$165K - $220K *

Join a team that's redefining avionics systems engineering by translating customer needs into innovative architectures and requirements. Collaborate across domains to deliver high-quality solutions in...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Aerospace & Defense

$80K - $95K *

Shape the future of construction by leading project teams, ensuring quality, safety, and compliance on-site. Collaborate with stakeholders to deliver exceptional results while managing resources and s...

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$105K - $127K *

Transform your career by leading EHSS programs that ensure compliance and promote a proactive safety culture. Collaborate cross-functionally to drive environmental stewardship and operational excellen...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$89K - $111K *

Drive impactful change by leading our Probate Law Team to support families facing housing uncertainty. Utilize your legal expertise to navigate complex probate cases, mentor staff, and ensure high-qua...

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$89K - $162K *

Unlock your potential as a Civil/Geotechnical Engineer, driving innovative ground improvement solutions for heavy civil projects. Collaborate with multidisciplinary teams to enhance project outcomes f...

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$171K - $200K *

Join a team that's driving innovation in clinical operations by managing and overseeing global clinical trials, ensuring compliance and timely delivery of compelling small molecule medicines while sup...

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Drive your career with a strategic sales leadership role focused on enterprise growth in healthcare. Lead complex business development efforts, build executive relationships, and shape solutions that...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$130K - $155K *

Lead the AI/ML product strategy across multiple business units, driving integration and data-centric solutions that enhance customer value and revenue growth through innovative workflows and collabora...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$70K - $98K *

Help us deliver exceptional patient care by providing vital clinical and clerical support. Collaborate with healthcare teams to ensure smooth workflows and assist in implementing medical plans, enhanc...

Today

  •   Less than 5 years exp.  •   Healthcare

$70K - $98K *

Elevate patient care by providing essential clinical and clerical support to healthcare teams, ensuring efficient workflow and high-quality service delivery while fostering collaboration with patients...

Today

  •   Less than 5 years exp.  •   Healthcare

$96K - $99K *

Drive innovation in Electrical Engineering by teaching and researching analog circuits, power management, and sensor technologies. Join a collaborative faculty to enhance educational programs and comm...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$160K - $190K *

Champion the transformation of Meta's infrastructure software stack by driving technical program management, collaborating with cross-functional teams, and ensuring successful platform adoption and de...

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$70K - $98K *

Support the patient care team by providing clinical and clerical assistance, ensuring efficient workflow and high-quality patient care through effective communication and technical skills...

Today

  •   Less than 5 years exp.  •   Healthcare

$105K - $169K *

Unlock potential by leading substation construction projects, ensuring compliance with engineering standards and safety regulations. Collaborate with teams to oversee project execution, manage contrac...

Today

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $225K *

Transform your career by leading data, cloud, and AI architecture initiatives. Collaborate with private equity firms to enhance technology strategies, assess risks, and drive enterprise value through...

Today

  •   8 - 10 years exp.  •   Business Services

$150K - $250K *

Lead the charge in expanding our water/wastewater engineering practice through strategic planning, innovation, and team development. Shape market presence and deliver excellence in project management...

Reposted today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$58K - $126K *

Lead the charge in educational recovery initiatives, driving impactful strategies and programs to enhance student learning outcomes and support community engagement through innovative solutions and co...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$75K - $120K *

Elevate client relationships by driving sales and service excellence across diverse markets. Collaborate with teams to maximize opportunities, ensuring client satisfaction and profitability through st...

Today

  •   Less than 5 years exp.  •   Energy & Utilities

$83K - $187K *

Join us to maintain and repair central plant equipment, ensuring optimal performance and reliability. Collaborate with teams to manage site-wide maintenance, troubleshoot issues, and provide technical...

Today

  •   5 - 7 years exp.  •   Energy & Utilities

$83K - $187K *

Transform the future of HVAC systems by overseeing maintenance and repairs of central plant equipment. Lead troubleshooting efforts and ensure compliance with safety standards while fostering positive...

Today

  •   5 - 7 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in California?question toggle

    California listings may include senior and specialized roles in technology, healthcare, finance, life sciences, entertainment, clean energy, manufacturing, and other fields. Available positions depend on current employer needs.

  • Where in California can I search for jobs?question toggle

    You can explore opportunities across the state, including major employment hubs such as Los Angeles, San Francisco, San Diego, San Jose, and Sacramento. Check each posting for its specific location and work arrangement.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review each listing for compensation information and details, since pay can vary by position and employer.

  • Can I find remote or hybrid California jobs?question toggle

    Some listings may offer remote or hybrid work, while others require on-site work. The job posting provides the employer’s location and work arrangement requirements.

  • How can I improve my California job search?question toggle

    Narrow your search by role, location, industry, and work arrangement. Keep your resume and profile updated, and carefully compare each opportunity’s qualifications and compensation details.