Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Vice President, Sales Jobs in South Dakota

Sort By: Relevance

$188K - $230K *

Lead product strategy and execution for TPA, PEO, and Carrier partners, driving innovation and operational excellence. Collaborate with cross-functional teams to enhance platform capabilities and deli...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $190K *

Transform ambiguity into action by driving strategic initiatives across functions. Collaborate with executives to architect programs that enhance operational efficiency and deliver measurable business...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in driving enterprise sales by managing the full sales cycle, engaging with large organizations, and expanding relationships within the AI sector. Your expertise will be pivotal in est...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $105K *

Shape impactful insights through analytics, driving data-informed decisions for healthcare clients. Collaborate with cross-functional teams to enhance marketing performance and audience understanding...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $145K *

Join a team that's driving growth through innovative product marketing strategies. You'll shape messaging, lead go-to-market initiatives, and enhance market positioning, ensuring our solutions resonat...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by leading communications strategy to enhance brand narrative, drive awareness and loyalty, and engage diverse stakeholders in a fast-paced environment that supports food waste reduct...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$73K - $131K *

Lead the charge in managing a dynamic team of analysts, delivering critical support for enterprise-wide projects. Drive strategic direction to meet customer service and sales needs while enhancing ope...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$136K - $214K *

Lead the charge in optimizing revenue operations by managing a dynamic team, enhancing forecasting processes, and ensuring data integrity across systems. Collaborate closely with sales leadership to d...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in tax preparation and compliance, overseeing a team to ensure accurate and timely filing of individual, corporate, and non-profit returns while enhancing workflow efficiency and mento...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$106K - $146K *

Champion the growth of alternative data solutions by building strategic relationships with institutional investors. Drive sales cycles, exceed targets, and shape go-to-market strategies while collabor...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$127K - $159K *

Join a team that's reshaping executive support through innovative AI-driven tools and strong people leadership. Manage high-performing Executive Business Partners, driving operational excellence and s...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $160K *

Advance credit risk strategies to optimize portfolio performance, leveraging data analysis and collaboration with cross-functional teams to drive growth and compliance in lending operations...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$75K - $125K *

Shape safety excellence by leading compliance initiatives in Process Safety Management. Collaborate with teams to implement and enhance safety programs, ensuring adherence to federal and state regulat...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$150K - $180K *

Transform growth strategies for military decision-making by leading market initiatives, conducting research, and nurturing relationships with key stakeholders in the U.S. Navy and defense sectors to e...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$102K - $147K *

Accelerate growth by developing strategic relationships with C-level executives to identify and secure new business opportunities, driving the entire sales cycle in a high-stakes environment focused o...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$145K - $175K *

Unlock potential by serving as a strategic advisor to enterprise clients, guiding them through complex stakeholder environments with predictive intelligence and data-driven insights to drive impactful...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$150K - $180K *

Transform enterprise relationships by driving strategic sales and fostering long-term partnerships in a dynamic AI infrastructure environment, engaging with C-level executives and guiding them through...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$240K - $310K *

Elevate your career as you lead a team of technical experts to develop innovative strategies that drive customer engagement and support business growth across diverse sectors...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$155K - $185K *

Champion growth and customer marketing by leading a dynamic team to drive full-funnel strategies, optimize campaigns, and leverage AI tools for enhanced performance and insights. Shape the future of m...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$115K - $140K *

Engage as an experienced implementation leader managing complex client onboarding and execution of digital banking solutions. Collaborate across teams to drive project success, enhance operational eff...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$107K - $157K *

Champion the growth of the Industrial Water market by leveraging your extensive network and commercial expertise to identify key talent, partner with leadership, and drive strategic hiring efforts wit...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Join a team that's shaping the future of in vitro diagnostics by leading complex, cross-functional product development projects from concept to launch in a regulated environment, ensuring compliance a...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$89K - $120K *

Shape the future of fleet management by driving product execution and enhancing user experiences in our EV and connected fleet ecosystem. Collaborate with cross-functional teams to deliver innovative...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$103K - $136K *

Join a dynamic team as you lead investment accounting and reporting efforts, ensuring accuracy and compliance. Collaborate across departments to enhance financial processes and drive improvements in a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Unlock potential by driving sales growth in the refinery sector, engaging customers, developing relationships, and executing tailored strategies to meet ambitious commercial objectives across the assi...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.