Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Vice President, Sales Jobs in South Dakota

Sort By: Relevance

$200K - $350K *

Unlock your potential as you structure and manage reinsurance programs, collaborating with cross-functional teams to ensure effective risk transfer and operational excellence in a dynamic environment...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Join us to drive product strategy and vision for finance functions, optimizing Record to Report and FP&A processes. Collaborate with cross-functional teams to enhance financial systems and ensure comp...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

$92K - $132K *

Collaborate with cross-functional teams to manage estimating operations, ensuring accurate material takeoffs and quality assurance for critical infrastructure projects while driving strategic bid supp...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$90K - $100K *

Reimagine retirement solutions by driving sales in small to mid-sized markets. Collaborate with financial intermediaries to build relationships and achieve company objectives while managing a dynamic...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$88K - $110K *

Accelerate growth by overseeing 12-15 locations, driving sales, and executing strategic initiatives while fostering team development and ensuring operational excellence across the district...

2 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$144K - $200K *

Lead a dynamic team to drive sales in the public safety sector, focusing on recruitment, coaching, and performance management. Collaborate across functions to enhance team effectiveness and achieve re...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$140K - $200K *

Champion growth by developing sales strategies, nurturing client relationships, and identifying market opportunities. Collaborate with teams to enhance offerings and drive success in the pharma and bi...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $191K *

Lead product strategy and execution by driving cross-functional teams to deliver high-quality solutions. Own the product lifecycle, prioritize impactful features, and leverage customer insights to ali...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$130K - $195K *

Transform enterprise sales by engaging CIOs and CTOs, leading complex sales cycles, and connecting technology strategies to measurable business outcomes. Collaborate with cross-functional teams to dri...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$90K - $120K *

Lead the charge in enhancing safety standards across multiple construction projects. Collaborate with field teams to ensure compliance and improve practices, making safety a priority and fostering a c...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $120K *

Empower growth by driving sales and client relationships, managing the full sales cycle, and ensuring customer satisfaction through high-level communication and CRM engagement. Join a results-driven t...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$85K - $114K *

Transform the Value-Added Reseller ecosystem by leveraging channel expertise to drive growth, engaging partners, and developing robust strategies for customer acquisition and revenue expansion within...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Unlock potential by driving BioPharma partnership success through innovative liquid biopsy solutions, enhancing clinical trial designs, and fostering key relationships in oncology precision medicine...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Transform complex product concepts into intuitive user experiences across various platforms. Collaborate in a high-ownership role, focusing on enterprise design that meets diverse user needs while ens...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Lead market expansion and provider relationships through consultative sales strategies, driving revenue growth and pipeline management within a dynamic healthcare environment while leveraging AI tools...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$112K - $143K *

Unlock your potential as a strategic sales leader driving growth in a dynamic market. Build and nurture relationships with brokers and partners while executing a comprehensive sales strategy to achiev...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $130K *

Champion customer relationships and drive sales strategies to enhance loyalty and achieve targets. Collaborate with teams to execute action plans, manage distributor salesforces, and ensure excellence...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Champion the advancement of commercial and U.S. civil launch opportunities, coordinating customer engagement and technical feedback while managing the qualification process and ensuring seamless trans...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$154K - $196K *

Unlock potential by leading strategic government programs, managing P&L, and driving operational excellence. Oversee contract delivery, mentor staff, and foster client relationships to ensure growth a...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $175K *

Elevate your career by leading data, analytics, and AI initiatives that drive strategic decision-making and operational excellence. Shape the future of our data ecosystem while collaborating with seni...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$71K - $118K *

Accelerate progress at client relationships by driving sales growth, consulting on laboratory services, and exceeding targets to enhance patient care. Collaborate effectively with stakeholders while m...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Transform your career by driving sales growth and client relationships in oncology. Leverage your expertise in radiopharmaceuticals to identify opportunities, manage accounts, and deliver exceptional...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Engage with business leaders to develop a profitable commercial insurance book. Leverage relationships and resources to create new opportunities, expand client accounts, and establish yourself as a tr...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Lead the charge in driving sales growth in the Elevator & Escalator market. Shape strategies, build relationships, and manage teams to optimize revenue in a fast-paced, dynamic environment across Nort...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$164K - $226K *

Unlock operational excellence by driving cross-functional initiatives that optimize customer strategy and enhance business intelligence. Collaborate with leaders to streamline decision-making and supp...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.