Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Vice President, Sales Jobs in South Dakota

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$110K - $130K *

Lead the development of vibration isolation and acoustic engineering capabilities, serving as a key technical resource. Collaborate with consultants and engineers to enhance product offerings and ensu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$75K - $90K *

Help us optimize customer success by leveraging your expertise to build strong partnerships, drive growth, and ensure satisfaction while enabling organizations to achieve their business objectives and...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Drive the transformation of our accounting function by leading the monthly close, enhancing financial systems, and developing a high-performing team. Leverage AI and automation to improve accuracy and...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $125K *

Lead the charge in mobilizing significant carbon transactions across Latin America, managing multi-stakeholder relationships and driving strategic initiatives to support forest protection programs und...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$135K - $185K *

Unlock potential by driving enterprise sales growth through strategic account management, leveraging industry expertise, and building strong client relationships to exceed revenue targets and enhance...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$158K - $213K *

Oversee day-to-day accounting and treasury operations, ensuring accuracy and compliance. Lead month-end close processes, refine internal controls, and develop a high-performing team while integrating...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$165K - $175K *

Empower progress at the forefront of data product management, leading the development of innovative solutions. Drive product success through strategic oversight, client engagement, and cross-functiona...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Explore a pivotal role in transforming tax compliance into operational confidence. Collaborate with senior Sales Engineers to engage enterprise clients, addressing complex challenges and delivering ta...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$152K - $190K *

Unlock growth by driving IoT solutions for mid-sized customers, managing complex sales cycles, and engaging with executives to deliver impactful sensor data solutions. Your efforts will enhance operat...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K *

Drive sales success by exceeding quotas and presenting innovative HCM/WFM solutions. Collaborate with a dedicated team to support proposals and demos, ensuring customer satisfaction and retention in a...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$120K - $150K *

Take ownership of an AI-driven product, shaping strategy, roadmap, and execution for enterprise content insights. Collaborate with cross-functional teams to enhance adoption and value in regulated sec...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$300K *

Drive enterprise sales success by leading complex cycles, building strategic relationships, and collaborating with cross-functional teams to enhance Zuddl's offerings and achieve measurable results in...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Accelerate your career by driving growth in healthcare sales. Leverage your expertise to build relationships with key accounts, navigate complex deals, and shape future services that impact the indust...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$96K - $144K *

Accelerate progress at player acquisition and retention through hands-on management of paid media, promotions, and analytics. Leverage AI and APIs to drive growth while owning the player-growth P&L in...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$115K - $140K *

Join a team that's dedicated to transforming patient engagement through innovative marketing strategies. You'll develop and execute multichannel campaigns, crafting compelling content that drives enro...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive transformative change in the construction industry by leveraging your General Contractor expertise to lead complex sales cycles and deliver innovative SaaS solutions that address customer pain p...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$144K - $162K *

Grow strategic partnerships to enhance revenue and customer experience. Collaborate across teams to develop innovative programs, optimize initiatives, and drive measurable impact while ensuring timely...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$108K - $180K *

Transform pharmacy services by driving strategic initiatives and cross-functional projects. Collaborate with stakeholders, analyze outcomes, and mentor team members while shaping the future of pharmac...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Accelerate growth by leading branch teams and cultivating financial advisor talent. Drive organic and inorganic growth through strategic coaching, community engagement, and effective management of bra...

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$104K - $123K *

Elevate your career as a strategic advisor to mid-market clients, driving growth and revenue. Manage your own portfolio, build lasting partnerships, and uncover new business opportunities in this dyna...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Drive growth by developing strategic partnerships and accelerating indirect sales through high-performing channel partners. Leverage your enterprise software expertise to exceed revenue goals and empo...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$280K - $300K *

Advance your career with a high-impact sales role focused on driving new business and expanding relationships within large enterprise accounts, leveraging cutting-edge AI technology to deliver measura...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $115K *

Join a dynamic team to drive sales of mission-critical technology for public safety. Engage with emergency response agencies, navigate complex procurement cycles, and deliver innovative solutions that...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$150K - $180K *

Deliver strategic procurement for critical mechanical and electrical equipment across multi-site data center builds. Manage supplier relationships and oversee sourcing strategies, ensuring alignment w...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$102K - $164K *

Join a team that's shaping the future of enterprise solutions by leading innovative design and implementation of scalable architectures. Collaborate with stakeholders, define strategy, and ensure adhe...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.