Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Vice President, Sales Jobs in South Dakota

Sort By: Relevance

$80K - $95K *

Accelerate growth by owning the full sales cycle in the U.S. MSP market. Build relationships at industry events, generate leads, and drive revenue for Comet Backup through consultative selling and str...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Elevate our deal desk function by transforming processes into a scalable model. You'll implement AI tools, streamline order forms, and ensure efficient deal structuring while collaborating with cross...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$115K - $136K *

Innovate by driving new business opportunities with executive finance leaders. Leverage your consultative sales skills to deliver transformative SaaS solutions, ensuring measurable outcomes and buildi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Empower organizations by driving adoption of Power Platform solutions, modernizing systems, and automating processes. You'll develop new and existing relationships, collaborating with teams and partne...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$200K - $250K *

Lead us in creating impactful marketing strategies, driving digital transformation, and fostering brand growth. Spearhead customer engagement initiatives, commercial excellence, and collaborative go-t...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Drive customer success by managing key accounts in cattle genomics. Collaborate with cross-functional teams to enhance service delivery, support genomic solutions, and ensure high-quality customer exp...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$255K - $310K *

Lead a high-performing team to execute market access strategies, optimize payer engagement, and enhance product positioning. Drive collaboration across stakeholders to ensure effective reimbursement a...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Shape strategic partnerships by owning enterprise account growth, fostering executive relationships, and leading cross-functional teams to drive market expansion while consistently achieving and forec...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$160K - $190K *

Empower nonprofit organizations to maximize their impact by leading product strategy and execution for innovative fundraising solutions. Drive growth through deep customer insights, collaborative part...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$135K - $200K *

Unlock potential by driving customer growth and engagement through consultative selling, leveraging AI insights to enhance account strategies and foster strong relationships with existing clients and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$206K - $260K *

Lead multi-market operations in a fast-paced environment, ensuring safety, efficiency, and compliance while managing P&L and team performance. Drive new district launches and stabilize existing operat...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Transportation

$280K - $400K *

Unlock potential by managing strategic accounts and fostering relationships with C-level executives at Fortune 500 clients, guiding them with innovative SaaS solutions, driving growth, and ensuring cu...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$170K - $200K *

Elevate tax administration services for exchange-traded funds by leading a dynamic team, resolving complex tax matters, and enhancing processes to support a growing fund platform while ensuring compli...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Drive growth in parts sales and profitability by overseeing operations, implementing strategies, and cultivating customer relationships. Lead a team to achieve sales targets while enhancing customer s...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$160K - $200K *

Drive the M&A strategy by leading the full transaction lifecycle, from sourcing to integration. Collaborate with executive leadership to identify growth opportunities that enhance enterprise value and...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$180K - $215K *

Join us to lead regional sales efforts, driving product launch success and team performance. You'll build strong customer relationships, execute strategic plans, and foster a high-performing culture i...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Transform the Sales and Customer Experience landscape by leading enablement and training initiatives. Oversee onboarding, training relevance, and cross-functional collaboration to enhance team perform...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$140K - $150K *

Manage and grow CPG and Grocery client portfolios by identifying expansion opportunities, nurturing key relationships, and executing strategic plans for revenue retention and growth while collaboratin...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $198K *

Unlock strategic growth by cultivating partnerships in the Beverage & Brewing sector. Collaborate with senior stakeholders to enhance customer success through innovative solutions, driving long-term v...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Business Services

$150K - $180K *

Shape the future of billing operations by leading a team to enhance accuracy, timeliness, and efficiency. Drive process improvements, manage complex accounts, and collaborate across functions to resol...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $180K *

Provide oversight for insurance accounting and reporting, driving process improvements and leveraging technology to enhance financial operations. Collaborate with teams to ensure compliance and accura...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K *

Drive regional sales success by leading a dynamic team, achieving revenue goals, and fostering collaboration. Utilize your expertise in capital medical equipment sales to mentor Territory Managers and...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$272K - $340K *

Elevate your career by leading CMC Regulatory strategy and execution. Drive submissions, build a high-performing team, and engage with global health authorities to ensure compliance and success in dru...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Advance your career by driving business development in clinical research and medical imaging. Build strategic client relationships, identify new opportunities, and contribute to innovative healthcare...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $200K *

Elevate your career by driving growth strategies that enhance lead generation for multiple brands. Collaborate with cross-functional teams to optimize acquisition channels and improve conversion rates...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.