Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Sales Executive, US (MSP Market)
$80K - $95K *
Accelerate growth by owning the full sales cycle in the U.S. MSP market. Build relationships at industry events, generate leads, and drive revenue for Comet Backup through consultative selling and str...
4 days ago
$135K - $160K *
Elevate our deal desk function by transforming processes into a scalable model. You'll implement AI tools, streamline order forms, and ensure efficient deal structuring while collaborating with cross...
3 weeks ago
$115K - $136K *
Innovate by driving new business opportunities with executive finance leaders. Leverage your consultative sales skills to deliver transformative SaaS solutions, ensuring measurable outcomes and buildi...
2 weeks ago
Business Development Sales Manager, Power Platform
$110K - $130K *
Empower organizations by driving adoption of Power Platform solutions, modernizing systems, and automating processes. You'll develop new and existing relationships, collaborating with teams and partne...
Reposted 2 weeks ago
Division Vice President Strategic Marketing & Commercial Excellence
$200K - $250K *
Lead us in creating impactful marketing strategies, driving digital transformation, and fostering brand growth. Spearhead customer engagement initiatives, commercial excellence, and collaborative go-t...
Reposted 1 week ago
$80K - $95K *
Drive customer success by managing key accounts in cattle genomics. Collaborate with cross-functional teams to enhance service delivery, support genomic solutions, and ensure high-quality customer exp...
3 weeks ago
Executive Director, Account Management
$255K - $310K *
Lead a high-performing team to execute market access strategies, optimize payer engagement, and enhance product positioning. Drive collaboration across stakeholders to ensure effective reimbursement a...
3 days ago
$125K - $150K *
Shape strategic partnerships by owning enterprise account growth, fostering executive relationships, and leading cross-functional teams to drive market expansion while consistently achieving and forec...
Reposted 3 weeks ago
$160K - $190K *
Empower nonprofit organizations to maximize their impact by leading product strategy and execution for innovative fundraising solutions. Drive growth through deep customer insights, collaborative part...
Reposted 1 week ago
Account Executive (CPQ Solutions)
$135K - $200K *
Unlock potential by driving customer growth and engagement through consultative selling, leveraging AI insights to enhance account strategies and foster strong relationships with existing clients and...
2 weeks ago
Vice President, Operations East
$206K - $260K *
Lead multi-market operations in a fast-paced environment, ensuring safety, efficiency, and compliance while managing P&L and team performance. Drive new district launches and stabilize existing operat...
1 week ago
Strategic Account Executive - Southeast
$280K - $400K *
Unlock potential by managing strategic accounts and fostering relationships with C-level executives at Fortune 500 clients, guiding them with innovative SaaS solutions, driving growth, and ensuring cu...
Reposted 3 weeks ago
$170K - $200K *
Elevate tax administration services for exchange-traded funds by leading a dynamic team, resolving complex tax matters, and enhancing processes to support a growing fund platform while ensuring compli...
2 weeks ago
Director - Customer Service Operations, MS
$110K - $130K *
Drive growth in parts sales and profitability by overseeing operations, implementing strategies, and cultivating customer relationships. Lead a team to achieve sales targets while enhancing customer s...
1 week ago
$160K - $200K *
Drive the M&A strategy by leading the full transaction lifecycle, from sourcing to integration. Collaborate with executive leadership to identify growth opportunities that enhance enterprise value and...
2 weeks ago
Regional Sales Director - Upstate NY
$180K - $215K *
Join us to lead regional sales efforts, driving product launch success and team performance. You'll build strong customer relationships, execute strategic plans, and foster a high-performing culture i...
5 days ago
$120K - $145K *
Transform the Sales and Customer Experience landscape by leading enablement and training initiatives. Oversee onboarding, training relevance, and cross-functional collaboration to enhance team perform...
1 week ago
$140K - $150K *
Manage and grow CPG and Grocery client portfolios by identifying expansion opportunities, nurturing key relationships, and executing strategic plans for revenue retention and growth while collaboratin...
Reposted yesterday
Associate Director, Corporate Accounts - Food and Beverage (Beverage and Brewing)
$135K - $198K *
Unlock strategic growth by cultivating partnerships in the Beverage & Brewing sector. Collaborate with senior stakeholders to enhance customer success through innovative solutions, driving long-term v...
3 days ago
$150K - $180K *
Shape the future of billing operations by leading a team to enhance accuracy, timeliness, and efficiency. Drive process improvements, manage complex accounts, and collaborate across functions to resol...
4 days ago
Senior Accounting Manager - Insurance
$160K - $180K *
Provide oversight for insurance accounting and reporting, driving process improvements and leveraging technology to enhance financial operations. Collaborate with teams to ensure compliance and accura...
2 weeks ago
Regional Sales Manager - Southeast
$140K *
Drive regional sales success by leading a dynamic team, achieving revenue goals, and fostering collaboration. Utilize your expertise in capital medical equipment sales to mentor Territory Managers and...
2 days ago
Vice President, CMC Regulatory Affairs
$272K - $340K *
Elevate your career by leading CMC Regulatory strategy and execution. Drive submissions, build a high-performing team, and engage with global health authorities to ensure compliance and success in dru...
6 days ago
Account Director, Medical Imaging and SS
$110K - $130K *
Advance your career by driving business development in clinical research and medical imaging. Build strategic client relationships, identify new opportunities, and contribute to innovative healthcare...
Reposted 1 week ago
Director of Growth (Recreation)
$180K - $200K *
Elevate your career by driving growth strategies that enhance lead generation for multiple brands. Collaborate with cross-functional teams to optimize acquisition channels and improve conversion rates...
3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.