Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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Vice President, Sales Jobs in South Dakota

Sort By: Relevance

$190K *

Champion operational excellence in the Americas, driving revenue performance through strategic leadership in sales, territory execution, and process optimization while fostering collaboration across t...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$125K - $150K *

Champion growth by driving sales strategies for pharmaceutical clients. Leverage your expertise to build relationships, develop tailored marketing solutions, and collaborate with teams to deliver exce...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$128K - $150K *

Help us drive growth in the Home Health and Pediatric Care sectors by generating new enterprise revenue. Own the full sales cycle, engage decision-makers, and develop strategic relationships to establ...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $200K *

Unlock potential by leading strategic sales initiatives that drive growth and forge strong relationships with key retail and eCommerce clients in a fast-paced environment requiring frequent travel. In...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$297K - $367K *

Grow your career with a pivotal role driving hospital data integration and compliance. Lead execution of clinical data operations, build relationships, and ensure secure data handling while shaping a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $250K *

Engage with diverse stakeholders to drive sales growth in FWA, M2M, and IoT solutions. Develop new customer relationships while enhancing existing accounts, leveraging a robust channel ecosystem to ma...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $200K *

Transform the enterprise account management landscape by leading strategy, driving revenue retention, fostering customer growth, and developing high-performing teams to enhance client relationships an...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $145K *

Drive growth by building strong partnerships with travel agencies, enhancing market share and brand awareness. Collaborate across teams to identify opportunities and execute strategies, making a signi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$95K *

Join a team that's driving growth by managing key Integrator accounts, developing sales strategies, and fostering relationships to exceed corporate goals in the material handling industry...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$171K - $214K *

Unlock potential by driving sales activation and enablement for MSP/MSSP partners. Engage in training, demand generation, and partner collaboration to ensure successful service launches and ongoing sa...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Build a robust pipeline in a dynamic sales role, driving net-new logo growth across public sector and energy verticals. Collaborate with stakeholders to execute complex deals and leverage CRM tools fo...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$112K - $143K *

Unlock new business growth by managing relationships and executing sales strategies across a designated territory. Drive market share expansion and achieve revenue targets through strategic networking...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$200K - $270K *

Drive your career with a global service organization, leading transformation in member services through automation and smarter workflows. Shape client retention and member trust while managing perform...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Healthcare

$180K - $215K *

Shape the future of our commercial launch by leading a regional sales team to drive market entry, foster customer relations, and exceed performance goals in a dynamic, cross-functional environment...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $195K *

Engage in strategic account acquisition for our Legal Technologies sector, focusing on sourcing, qualifying, and closing new enterprise accounts. Drive revenue growth through complex sales cycles whil...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$200K - $300K *

Accelerate sales growth in the Pacific Northwest by leading a dynamic team in Washington, Oregon, and Idaho. Drive accountability, enhance pipeline management, and foster a high-performance culture th...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Join a dynamic team to elevate client relationships and deliver exceptional wealth management services, supporting key investment strategies and ensuring client satisfaction with detailed financial an...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Finance & Insurance

$115K - $130K *

Engage with stakeholders to drive product strategy and enhance the Affordable Equity platform. Collaborate with teams to translate user needs into actionable solutions, ensuring timely delivery and al...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$185K - $210K *

Lead the charge in optimizing revenue operations by enhancing forecasting, analytics, and sales strategies to drive growth and accountability across North America’s sales teams, ensuring alignment and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $160K *

Lead the Enterprise Americas team to drive new-logo bookings and build a repeatable sales engine. Coach reps on multi-threaded deals and foster a strong outbound culture as the team scales. Shape ente...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $110K *

Advance national account strategies and sales growth through effective relationship building and business planning. Collaborate across teams to negotiate contracts, leverage competitive advantages, an...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$112K - $143K *

Engage with key stakeholders to drive revenue growth and expand market share. This role requires strategic networking, relationship management, and a strong field presence to achieve sales targets and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $185K *

Shape strategic success for key accounts by leading market access initiatives, collaborating with cross-functional teams, and driving growth through innovative solutions and insights in the managed ma...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $140K *

Elevate regional performance by leading strategic initiatives, optimizing operations, and fostering team development. Drive financial success and enhance market presence while ensuring exceptional ser...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Transform your career by driving sales for innovative SaaS solutions in a dynamic environment. Leverage your expertise to engage Fortune 1000 clients, navigate complex sales cycles, and exceed revenue...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.