Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$120K - $145K *

Accelerate commercial growth by defining strategies for product families, collaborating across teams to translate market insights into actionable plans that drive revenue, profitability, and customer...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Healthcare

$176K - $243K *

Accelerate progress at the forefront of cardiovascular innovation, leading a dynamic team to drive the adoption of advanced imaging solutions in the U.S. market, while fostering strategic partnerships...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Healthcare

$80K - $120K *

Engage clients by driving sales of Managed and Professional Services, identifying opportunities, and delivering tailored solutions. Cultivate relationships to exceed revenue targets while leveraging i...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$300K - $350K *

Empower sales growth by acquiring new accounts and nurturing relationships in the cybersecurity sector. Drive customer satisfaction and retention while exceeding quotas and managing Channel Partner re...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$250K - $280K *

Shape the future of our enterprise sales segment by driving growth and account success. Take ownership of new logo acquisitions, deepen existing client relationships, and establish best practices for...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$91K - $110K *

The Account Executive in San Diego is responsible for managing the full sales cycle, including prospecting, building relationships, and closing deals. This role requires a proactive approach to expand...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Business Services

$180K - $220K *

Lead the development and execution of global government affairs strategies, fostering relationships with key stakeholders and providing strategic counsel on policy and regulatory matters impacting the...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$84K - $131K *

Partner with us to enhance internal audit processes, evaluate risks, and ensure compliance. Collaborate with teams to assess controls, document findings, and support management in implementing effecti...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $110K *

Lead the charge in developing high-performing sales teams while mastering our sales system. Focus on personal sales and training others to excel, ensuring a strong rapport with customers and adherence...

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$175K - $219K *

Optimize medical sponsorship strategies and operations by collaborating with stakeholders, managing budgets, and ensuring timely execution of congress activities while enhancing process efficiency and...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Drive new business growth by owning strategic accounts in the automotive sector. Collaborate with key stakeholders, navigate complex organizations, and leverage insights to shape our go-to-market stra...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$88K - $100K *

Transform enterprise sales by driving full-cycle processes, building multi-stakeholder relationships, and leveraging AI tools to achieve quota and deliver impactful solutions to large organizations...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$163K - $261K *

Shape the future of electrification services by leading operations across the West U.S. region, driving performance excellence, and managing nationwide digital automation initiatives while advancing r...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$99K - $166K *

Elevate marketing impact by leading multi-channel campaigns in healthcare. Drive strategic initiatives, ensure brand consistency, and collaborate cross-functionally to maximize engagement and measurab...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Champion global physical security and resiliency initiatives by providing strategic leadership to enhance safety for employees and assets while driving compliance across all company operations and thi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$145K - $185K *

Shape the future of channel marketing by driving co-marketing strategies with partners in the South Central region. Collaborate to enhance pipeline growth and ensure ROI through innovative field progr...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$350K *

Unlock potential by driving revenue growth through strategic relationships with enterprise customers. Engage in complex sales cycles, championing customer success while thriving in a high-performance...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$290K - $436K *

Elevate our mobile engineering organization by leading teams, driving modernization, and ensuring app performance and quality. Collaborate with cross-functional partners to innovate and mentor future...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Lead the charge in transforming marketing operations through innovative MarTech solutions, driving student and partner success while optimizing efficiency across a multi-brand ecosystem. Own product s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$120K - $150K *

Join a team that's shaping the future of consulting in P&C insurance. Lead client engagements, ensure quality standards, and foster long-term relationships while driving business growth and mentoring...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Drive go-to-market strategy for AI-powered healthcare solutions, collaborating cross-functionally to enhance product positioning, messaging, and performance. Own marketing execution and leverage insig...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $140K *

Join a dynamic team as you drive sales in the public safety sector, managing a diverse territory. Leverage AI tools to identify opportunities, close deals, and build lasting relationships with agencie...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$91K - $110K *

Tackle the full sales cycle as you build relationships, manage your pipeline, and drive revenue growth in the SF/Bay Area. Leverage your expertise to prospect, negotiate, and close deals while serving...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Business Services

$90K - $105K *

Lead the charge in expanding OEM business by identifying opportunities, nurturing client relationships, and delivering tailored HVACR solutions that drive customer satisfaction and business growth acr...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Elevate your marketing career by leading integrated organic campaigns that drive engagement and revenue growth. Collaborate cross-functionally to optimize strategies across social media, email, and ac...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.