Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$125K - $150K *

Transform complex product concepts into intuitive user experiences across various platforms. Collaborate in a high-ownership role, focusing on enterprise design that meets diverse user needs while ens...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Lead market expansion and provider relationships through consultative sales strategies, driving revenue growth and pipeline management within a dynamic healthcare environment while leveraging AI tools...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$112K - $143K *

Unlock your potential as a strategic sales leader driving growth in a dynamic market. Build and nurture relationships with brokers and partners while executing a comprehensive sales strategy to achiev...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$265K - $295K *

Unlock potential by leading a global Customer Success team, driving client satisfaction, renewals, and growth in the Wellbeing division. Collaborate with executives to shape strategy and enhance clien...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $130K *

Champion customer relationships and drive sales strategies to enhance loyalty and achieve targets. Collaborate with teams to execute action plans, manage distributor salesforces, and ensure excellence...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$95K - $158K *

Transform the Property Intelligence platform by connecting customer needs with product insights. Collaborate across teams to enhance product adoption and engagement through analytics and feedback, dri...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$154K - $196K *

Unlock potential by leading strategic government programs, managing P&L, and driving operational excellence. Oversee contract delivery, mentor staff, and foster client relationships to ensure growth a...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $175K *

Elevate your career by leading data, analytics, and AI initiatives that drive strategic decision-making and operational excellence. Shape the future of our data ecosystem while collaborating with seni...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$300K - $350K *

Join a team that's driving sales growth in the cybersecurity sector. This role focuses on acquiring new accounts, building customer relationships, and ensuring satisfaction while exceeding sales quota...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Engage with business leaders to develop a profitable commercial insurance book. Leverage relationships and resources to create new opportunities, expand client accounts, and establish yourself as a tr...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$126K - $191K *

Lead the charge in implementing an integrated risk framework across the enterprise, enhancing resilience and oversight while guiding teams in risk management, business continuity, and crisis response...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$143K - $291K *

Join a team that's dedicated to empowering healthcare professionals through innovative medical devices. Lead a high-performing sales organization, drive revenue growth, and enhance patient care with c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$250K - $300K *

Join a dynamic team as you drive enterprise sales across mid-market to Fortune 500 accounts. Own the entire sales cycle, engage multi-stakeholder buying committees, and leverage AI tools to redefine b...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Champion revenue growth and market expansion by leveraging consultative sales techniques to drive adoption of innovative educational solutions in K-12 districts, fostering strong relationships and exc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $150K *

Join a team that's driving growth in the Food & Beverage sector by acquiring new customers and revitalizing inactive accounts. This role focuses on market opportunities, relationship building, and est...

4 days ago

  •   5 - 7 years exp.  •   Business Services

$175K - $195K *

Unlock potential by leading strategic M&A initiatives across Europe and APAC. Drive deal execution with autonomy, manage due diligence, and collaborate with senior leadership to shape investment strat...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $145K *

Shape the future of data collaboration by leading product strategy for clean rooms and data delivery platforms. Drive innovation in privacy-conscious solutions while ensuring scalability and alignment...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $263K *

Empower the financial future of the organization by leading strategic financial initiatives, ensuring compliance, and fostering a culture of transparency and collaboration across teams to drive sustai...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Lead a dynamic team to enhance customer success, drive retention, and maximize revenue growth. Shape strategies and workflows while collaborating cross-functionally to deliver exceptional value and ou...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$141K - $194K *

Transform commercial operations by leading cross-functional initiatives, driving clarity, execution, and impactful outcomes. Collaborate with diverse teams to continuously enhance processes and integr...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Join us to lead and optimize our operations, ensuring seamless processes across revenue, contracts, partnerships, and people management. You'll build a team and systems that empower growth, driving ef...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Staffing

$122K - $405K *

Drive the global partner marketing strategy, leading initiatives across channels, technology, and strategic partners to enhance demand generation and pipeline growth. Collaborate with cross-functional...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Consumer Technology

$110K - $130K *

Transform educational outcomes by leading strategic partnerships with K-12 districts. Leverage your expertise to drive literacy initiatives, influence district strategies, and foster long-term relatio...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$131K - $180K *

Lead the transformation of enterprise pricing by managing the implementation of a modern pricing platform, ensuring seamless integration across departments while driving governance, change management...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Healthcare

$119K - $142K *

Join a team that's redefining digital operations by leading strategic initiatives, enhancing customer experiences, and driving growth in a fast-paced environment. Shape the future of MODAL Digital whi...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.