Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$140K - $180K *

Transform the digital manufacturing landscape by driving sales growth and market expansion. Collaborate across teams to develop strategies, support federal opportunities, and enhance customer value th...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$100K - $122K *

Unlock your potential as you lead financial planning, analytics, and strategic initiatives. Collaborate closely with executives to drive performance improvements and optimize resource allocation, fost...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $260K *

Lead strategic partnerships to elevate and scale multi-year AI and LLM relationships. Collaborate cross-functionally to deepen alliances, drive integration optimizations, and advance collaborative opp...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Engage with clients to drive sales growth in the Carolinas, leveraging your expertise in relationship building and problem-solving. Collaborate with teams to deliver tailored solutions and enhance cus...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $170K *

Partner with us to drive growth and strengthen relationships with key strategic accounts. Leverage your expertise in enterprise sales to identify opportunities, ensure renewals, and deliver measurable...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead the development and scaling of our connector ecosystem, collaborating with cross-functional teams to transform strategic opportunities into actionable product initiatives that enhance client mark...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a team that's redefining business identity solutions. As a Product Manager, you'll drive strategy, development, and performance of our Business Identity Graph, collaborating with cross-functional...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Unlock potential by directing product strategy for data-centric solutions, collaborating across teams to enhance product performance and drive innovation. Own the product lifecycle from conception to...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Elevate product management by integrating diverse datasets into innovative solutions. Collaborate with cross-functional teams to enhance existing products and drive new data initiatives from concept t...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Champion customer success by owning relationships, driving adoption, and ensuring renewals. Leverage deep trust to generate qualified leads while proactively engaging law firm accounts to enhance thei...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$179K - $248K *

Lead the charge in operationalizing strategy and driving cross-division initiatives. Collaborate with senior stakeholders to enhance efficiency and client satisfaction in a fast-paced corporate travel...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$130K - $160K *

Unlock potential by driving sales and education in oncology medical devices. Collaborate with healthcare professionals to enhance treatment options for liver and pancreatic cancer while achieving regi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$280K *

Lead the charge in driving enterprise sales across the TOLA region, building strong relationships and collaborating with cross-functional teams to deliver exceptional customer experiences and achieve...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $200K *

Drive impactful marketing strategies in the Healthcare sector, enhancing positioning and messaging. Collaborate cross-functionally to accelerate growth and establish thought leadership, ensuring relev...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Empower partner success by managing relationships, enhancing product adoption, and driving engagement. Collaborate with cross-functional teams to deliver exceptional service and support, ensuring part...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$150K - $180K *

Advance healthcare solutions by building executive relationships and driving enterprise sales. Lead the sales lifecycle, develop strategic accounts, and leverage modern tools to optimize revenue growt...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$196K - $353K *

Join us to lead the West Region Oncology Sales team, driving strategy and execution for a groundbreaking mRNA therapy. Collaborate with partners, build relationships, and ensure launch excellence whil...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Drive customer success by managing complex onboarding projects, ensuring alignment across teams, and delivering high-quality implementations. This role is pivotal in creating structured processes in a...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$200K - $250K *

Champion innovative financing strategies to drive growth in a dynamic energy infrastructure company. Oversee capital funding, asset finance, and deal design while building a high-performing finance te...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Transportation

$340K *

Elevate your career by driving strategic sales in the TOLA region. Collaborate with cross-functional teams to build relationships, uncover opportunities, and deliver value through innovative SaaS solu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $190K *

Lead the charge in underwriting and managing complex enterprise accounts, driving profitable business through strategic broker partnerships while mentoring junior underwriters and shaping portfolio st...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$109K - $128K *

Empower industries by bridging cutting-edge IoT technology with operational excellence. Collaborate across teams to drive customer success while enhancing logistics, safety, and sustainability through...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$87K - $109K *

Transform public-sector auction services by building relationships with key decision-makers. Drive business growth through strategic outreach, presentations, and consultative selling, ensuring long-te...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$160K - $220K *

Engage with higher education institutions to foster relationships, drive customer success, and expand platform adoption. Balance strategic management and revenue growth in a dynamic environment, ensur...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Elevate customer engagement by leading SaaS renewal strategies, fostering relationships, and driving growth through negotiation and operational excellence in a dynamic environment...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.