Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$81K - $100K *

Deliver exceptional client service by managing strategic accounts, driving retention, and fostering growth. Collaborate with cross-functional teams to address customer needs and expand business opport...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$150K - $180K *

Empower business growth by building strategic relationships and originating multifamily loans. Utilize your expertise to manage the loan process, advise clients, and enhance community presence in the...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$174K - $261K *

Empower enterprise transformation by leading a specialized sales team focused on cloud, data, and AI solutions. Drive strategic partnerships, coach high-performing sellers, and enhance technology stra...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$183K - $301K *

Accelerate growth by leading strategic partnerships and go-to-market initiatives in the healthcare ecosystem. Drive revenue through collaboration, executive influence, and innovative business models w...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Healthcare

$300K - $350K *

Transform business performance by leading strategic initiatives and continuous improvement efforts. Collaborate with senior leaders to drive accountability, enhance operational efficiency, and foster...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$216K - $361K *

Elevate your career by driving sales growth in enterprise software across retail, energy management, and telecommunications. Collaborate with top clients to achieve strategic goals and expand market p...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $105K *

Elevate client relationships by managing post-sale engagements, ensuring project success, and driving account growth. Collaborate with internal teams to deliver value and strengthen partnerships acros...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K *

Join a team that's driving growth by onboarding and activating merchants in the home services sector. This role involves managing the sales process, collaborating cross-functionally, and maintaining a...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Elevate safety standards by leading a comprehensive safety strategy, fostering a proactive culture, and driving continuous improvement across multi-site operations while ensuring compliance with indus...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$175K - $225K *

Lead the charge in shaping product strategy and execution, driving innovation and collaboration across teams to deliver impactful solutions in a fast-paced B2B SaaS environment. Own the product roadma...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $190K *

Accelerate progress at senior living communities by leading a high-performing Customer Success team, ensuring measurable outcomes and fostering strong partnerships to enhance care delivery and custome...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $215K *

Transform your career by leading regional sales efforts for a groundbreaking product. Drive performance, build a high-performing team, and engage with key healthcare providers in a fast-paced, entrepr...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$228K - $380K *

Lead the charge in developing a high-performing sales team to drive growth in the Enterprise segment, ensuring consistent achievement of sales targets and fostering collaboration across departments fo...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Business Services

$90K - $110K *

Elevate your career by driving LPG tank sales across the Eastern US. Build lasting relationships with propane marketers and distributors while executing a results-driven commercial strategy to achieve...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$190K *

Champion operational excellence in the Americas, driving revenue performance through strategic leadership in sales, territory execution, and process optimization while fostering collaboration across t...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$125K - $150K *

Champion growth by driving sales strategies for pharmaceutical clients. Leverage your expertise to build relationships, develop tailored marketing solutions, and collaborate with teams to deliver exce...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$128K - $150K *

Help us drive growth in the Home Health and Pediatric Care sectors by generating new enterprise revenue. Own the full sales cycle, engage decision-makers, and develop strategic relationships to establ...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $200K *

Unlock potential by leading strategic sales initiatives that drive growth and forge strong relationships with key retail and eCommerce clients in a fast-paced environment requiring frequent travel. In...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$297K - $367K *

Grow your career with a pivotal role driving hospital data integration and compliance. Lead execution of clinical data operations, build relationships, and ensure secure data handling while shaping a...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $250K *

Engage with diverse stakeholders to drive sales growth in FWA, M2M, and IoT solutions. Develop new customer relationships while enhancing existing accounts, leveraging a robust channel ecosystem to ma...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$193K - $238K *

Unlock potential by driving enterprise sales strategies to acquire new clients. Engage with C-level executives, manage key accounts, and exceed revenue goals while advocating for innovative EHS soluti...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$130K - $145K *

Drive growth by building strong partnerships with travel agencies, enhancing market share and brand awareness. Collaborate across teams to identify opportunities and execute strategies, making a signi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$95K *

Join a team that's driving growth by managing key Integrator accounts, developing sales strategies, and fostering relationships to exceed corporate goals in the material handling industry...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$171K - $214K *

Unlock potential by driving sales activation and enablement for MSP/MSSP partners. Engage in training, demand generation, and partner collaboration to ensure successful service launches and ongoing sa...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$112K - $143K *

Unlock new business growth by managing relationships and executing sales strategies across a designated territory. Drive market share expansion and achieve revenue targets through strategic networking...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.