Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Account Director Jobs in Missouri

Sort By: Relevance

$150K - $180K *

Inspire growth by driving enterprise partnerships in healthcare. Leverage your sales expertise to lead complex cycles, build relationships with C-suite stakeholders, and shape strategic initiatives in...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Advance your career by managing and growing a key business segment, developing strategic sales plans, and fostering relationships with distributors and national accounts to drive revenue and market pr...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$165K - $265K *

Champion governance excellence by leading policy frameworks, enhancing Board operations, and driving AI-enabled improvements. Engage with investors and committees to elevate governance practices at a...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$150K - $180K *

Inspire patient recruitment strategies by leading a dynamic team, collaborating with senior management, and leveraging innovative tools to enhance enrollment across clinical trials while ensuring dive...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $135K *

Transform the insurance landscape by leading product innovation and development initiatives, enhancing personal Property products to meet member needs and drive profitable growth while ensuring market...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$84K - $103K *

Shape the future of startup financing by connecting innovative companies with vital capital solutions. Collaborate with founders and investors to develop tailored fundraising strategies and enhance th...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$148K - $201K *

Drive category strategy and supplier relationships to enhance Market Access, Pricing, and Health Economics. Collaborate with cross-functional teams to optimize procurement processes and improve operat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in enhancing client experiences by championing a culture of CARE. Collaborate across departments to implement strategic initiatives, develop training programs, and ensure consistent, h...

1 month ago

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $130K *

Innovate solutions by bridging business challenges with AI-driven strategies. Lead stakeholder engagement, design value streams, and ensure technology investments yield measurable outcomes through eff...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Elevate your project management career by leading a strategic platform within investor client coverage, enhancing client engagement and driving technology integration across CBRE's commercial real est...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$185K - $344K *

Champion the evolution of field intelligence capabilities, driving strategic governance and analytics integration to enhance decision-making and execution support across the organization, ensuring ali...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Optimize the commercial loan documentation process by leading a team, ensuring compliance with regulations, and enhancing workflow efficiency. Engage with various units to deliver high-quality, legall...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $375K *

Join a team that's transforming life sciences through strategic commercial leadership. Drive large-scale engagements, foster client relationships, and deliver innovative solutions that enhance operati...

2 weeks ago

  •   11 - 15 years exp.  •   Business Services

$110K - $130K *

Drive effective resolution of pre-litigation disputes and manage claims while collaborating with legal and business teams to implement best practices and mitigate risks in a dynamic environment...

6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$135K - $160K *

Transform client relationships by leading customer success strategies, driving utilization, and maximizing retention across enterprise health systems. Oversee a high-performing team to ensure client s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$274K - $371K *

Elevate patient care through innovative clinical strategies in obesity and cardiometabolic development. Collaborate across teams to design and implement late-phase studies, ensuring alignment with glo...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Join a dynamic team to drive growth in the pharmaceutical sector, leveraging your expertise to build relationships, win new business, and deliver impactful solutions that enhance brand performance and...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Champion the digital experience by optimizing user flows, managing web content, and enhancing conversion strategies to drive engagement and pipeline growth for a leading B2B SaaS platform...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $100K *

Optimize revenue growth by driving GTM excellence and data-driven insights. Collaborate across Sales, Customer Success, and Finance to establish streamlined operations and enhance performance reportin...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Advance your career by leading complex projects that drive strategic goals. Collaborate with cross-functional teams to ensure timely delivery, compliance, and risk management while enhancing business...

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Lead the charge in managing complex projects that drive strategic goals. Oversee project lifecycles, ensuring timely delivery, compliance, and stakeholder engagement while fostering collaboration acro...

St. Louis, MORemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$71K - $125K *

Transform client relationships by supporting sales and credit functions, managing lending processes under $10M, and ensuring data integrity. Collaborate with teams to create impactful pitch materials...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Drive analytical excellence by auditing freight contracts and invoices, ensuring compliance and accuracy. Collaborate with teams to enhance audit processes and mentor junior analysts, contributing to...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$70K - $110K *

Lead efforts in healthcare sales development by researching and qualifying accounts, engaging senior executives, and collaborating with marketing and sales teams to build a robust pipeline and drive m...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Explore new business opportunities and build lasting client relationships. Drive the full sales cycle, from prospecting to closing, while collaborating with cross-functional teams to deliver tailored...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.