Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$90K - $130K *

Drive business growth by executing strategic sales plans and building client relationships. Leverage industry tools to identify prospects, present solutions, and negotiate contracts while collaboratin...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $115K *

Take ownership of strategic account management to drive growth and enhance educational outcomes. Collaborate with key stakeholders, leverage data insights, and implement targeted strategies to maximiz...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$175K - $200K *

Lead the charge in developing integrated media strategies and client partnerships across pharmaceutical and life sciences accounts, driving business growth and ensuring exceptional delivery and client...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$145K - $175K *

Unlock potential by serving as a strategic advisor to enterprise clients, guiding them through complex stakeholder environments with predictive intelligence and data-driven insights to drive impactful...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Media

$134K - $160K *

Lead the charge in paid social strategy and performance for eCommerce brands. Drive measurable growth, mentor teams, and elevate operational standards while navigating complex client challenges with c...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$172K - $203K *

Empower the distribution strategy by designing and managing rate content across channels, ensuring accurate delivery and partner trust. Collaborate with cross-functional teams to build scalable progra...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Accelerate growth by building a new region from scratch, driving sales, and establishing customer success stories for a groundbreaking FinOps solution. Own the full sales cycle, focusing on net-new lo...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $190K *

Lead the charge in driving growth by managing a high-performing sales team, collaborating across functions, and executing strategic initiatives to enhance commercial success in the Hematology sector...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$85K - $105K *

Champion exceptional client relationships by delivering innovative solutions, managing campaigns, and driving strategic marketing goals to enhance performance and satisfaction for high-value clients i...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$165K - $180K *

Transform your career by driving new customer acquisition in healthcare. Leverage your expertise to build C-suite relationships and lead complex sales processes, contributing to the growth of a dynami...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Technical Services

$110K - $130K *

Champion strategic growth by managing key accounts, fostering relationships, and driving sales initiatives. Collaborate with leadership to meet customer needs and exceed performance objectives while r...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$140K - $170K *

Elevate enterprise sales by leading full-cycle engagements with large insurance carriers, leveraging consultative selling and technical fluency to drive value through innovative solutions and strategi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $120K *

Grow your career with a dynamic sales role, driving supply chain transparency for leading brands. Own the full sales cycle, engage senior stakeholders, and develop solutions that enhance customer valu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Unlock new business opportunities and expand existing client relationships by leveraging your expertise in enterprise sales. Collaborate with teams to deliver tailored solutions and drive growth in a...

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $135K *

Help us drive success for enterprise clients by managing key accounts, offering strategic guidance, and ensuring seamless project delivery. Elevate your career by collaborating with top-tier clients i...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$145K - $150K *

Join a team that's redefining pay equity solutions. Drive sales cycles, engage with enterprise clients, and leverage innovative tech to ensure fair compensation practices. Collaborate with diverse sta...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $175K *

Lead the charge in expanding market penetration and building strategic partnerships within key healthcare organizations, utilizing your expertise to foster strong relationships and drive adoption of i...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Drive growth across the Americas by leading sales strategies, building key relationships, and delivering innovative solutions that enhance airport performance. Shape the future of airport operations w...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$285K - $500K+*

Transform digital marketing strategies by leading a global team to enhance demand generation and pipeline growth through innovative media tactics and data-driven optimization across diverse channels...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Enterprise Technology

$160K - $200K *

Unlock potential by leading strategic sales initiatives that drive growth and forge strong relationships with key retail and eCommerce clients in a fast-paced environment requiring frequent travel. In...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$150K - $220K *

Unlock your potential by managing the full sales cycle, from prospecting to closing, while fostering lasting client relationships and exceeding sales goals in a fast-paced environment...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$152K - $190K *

Reimagine how mid-sized organizations leverage IoT data to drive efficiency and safety. As an integral sales force, you will engage with key decision-makers to build relationships, manage projects, an...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$64K - $134K *

Drive success by managing key accounts, ensuring revenue growth through strategic upselling and relationship building. Collaborate with clients and internal teams to deliver exceptional service and ac...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $115K *

Explore a strategic leadership role focused on developing omnichannel engagement strategies that connect media, analytics, and customer experiences, driving measurable outcomes for healthcare brands a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$75K - $90K *

Join a dynamic team to drive B2B sales growth through innovative data solutions. This role empowers you to engage prospects, craft compelling conversations, and lead the sales journey with a focus on...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.