Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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650

Vice President, Sales Jobs in South Dakota

Sort By: Relevance

$80K - $100K *

Unlock potential by driving sales growth in a dynamic territory, cultivating relationships with diverse clients, and leveraging technical expertise to deliver effective packaging solutions that surpas...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$125K - $150K *

Lead the charge in transforming public sector consulting by guiding organizations through digital transformation and ERP implementations, while managing high-impact teams and fostering client relation...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Accelerate your career by driving revenue growth and managing key accounts in the Western U.S. and Canada. Focus on expanding customer relationships and delivering value through consultative selling w...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$75K - $90K *

Elevate your career by driving growth as an Account Executive, where you'll engage clients, deliver tailored software solutions, and build lasting relationships in the automotive industry. Join us in...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$80K - $95K *

Drive your career forward by cultivating client relationships and exceeding sales goals. As a key player, you'll develop marketing strategies, engage decision-makers, and provide tailored solutions to...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Join a team that's redefining sales excellence by driving revenue growth and market expansion for innovative SynBio products. Lead a dynamic team, develop strategies, and enhance customer experiences...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $240K *

Drive customer success across the Americas by leading a high-performing team focused on retention, expansion, and satisfaction, ensuring operational excellence in both pre and post-sales experiences f...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Media

$142K - $197K *

Drive strategic improvements and operational efficiency in Partnerships by establishing frameworks, integrating AI solutions, and optimizing team performance, all while collaborating with cross-functi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $115K *

Grow and lead a high-performing BDR team, driving pipeline success through strategic coaching and data-driven insights. Collaborate cross-functionally to optimize sales processes and ensure seamless h...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$189K - $196K *

Join us to develop strategic partner relationships that drive revenue and growth across the Central US. This role combines sales acumen with collaboration to create sustainable partnerships in a dynam...

RemoteRemote

Reposted 1 month ago

  •   8 - 10 years exp.  •   Information Technology

$239K - $358K *

Join a team that's committed to maximizing growth in pharmaceutical accounts through strategic planning and relationship building, focusing on data-driven solutions and real-world evidence to foster l...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Transform your career by driving new revenue growth in diverse industries. As a key sales leader, you'll identify prospects, develop relationships, and deliver tailored marketing solutions, ensuring c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$160K - $200K *

Drive growth and strengthen relationships across community clinics and AICs. Develop new business and expand partnerships while collaborating with key decision-makers in a complex healthcare market. T...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $300K *

Champion a high-performing team of Inside Account Executives to exceed sales targets and enhance customer relationships, driving growth in the Public Sector through effective leadership, coaching, and...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$120K - $130K *

Grow your career with a dynamic role driving regional sales and dealer engagement. Collaborate with independent reps to develop strategies, enhance relationships, and deliver exceptional customer expe...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$180K - $240K *

Lead strategic business initiatives by building relationships with senior executives to drive revenue growth in life sciences. Develop actionable plans to identify opportunities and enhance market pos...

United StatesRemote

Reposted 1 week ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$170K - $180K *

Lead the strategic execution of commercial planning and sales coverage, aligning cross-functional teams to drive profitable growth. Oversee territory design, customer segmentation, and annual planning...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$112K - $143K *

Join us to drive growth by identifying and securing new B2B payment opportunities. Leverage your consultative sales skills to manage the full sales cycle, build client relationships, and optimize our...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$250K - $300K *

Champion strategic growth by leading the charge to secure complex health system accounts. Drive transformative deals with hands-on coaching, leveraging deep relationships and expertise to elevate team...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Healthcare

$210K - $250K *

Join a team that's driving strategic growth and profitability in healthcare solutions. Lead cross-functional initiatives, own P&L, and ensure client success while shaping market strategy and solution...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Healthcare

$187K - $246K *

Accelerate health plan growth by originating and closing partnerships while developing impactful genomic insights. Collaborate closely with stakeholders to drive innovative programs that enhance care...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Healthcare

$185K - $400K *

Transform the retirement landscape by leading a dynamic sales team, driving growth, and enhancing client relationships in the Defined Contribution market. Your strategic vision will shape the future o...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

$250K - $500K *

Transform delivery services by owning P&L and driving strategy across complex networks and AI solutions. Lead a large-scale team, ensuring quality and efficiency while enhancing customer satisfaction...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$135K - $160K *

The Director of Strategic Accounts is responsible for developing and closing business with Motive's largest prospects, primarily targeting Fortune 500 companies. This role involves building relationsh...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$230K - $275K *

Join a team that's redefining B2B sales by leading and mentoring a high-performing regional team while driving significant revenue growth and building a vibrant sales culture in a rapidly scaling envi...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.