Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Vice President, Sales Jobs in South Dakota

Sort By: Relevance

$80K - $95K *

Transform customer relationships by driving strategic account growth, enhancing engagement, and achieving sales targets. Collaborate with cross-functional teams to meet client needs and deliver except...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$180K - $205K *

Drive financial excellence by delivering insights and analysis for the Field Service organization. Collaborate across departments to enhance forecasting, budgeting, and operational efficiency while su...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$67K - $95K *

Champion business growth by driving sales through strategic prospecting and consultative selling. Build and manage a diverse client portfolio, leveraging technology and relationships to exceed quotas...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Join a team that's focused on enhancing client delivery and relationship growth. Drive data-driven strategies and cross-functional collaboration to optimize post-sale operations, ensuring exceptional...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Empower your career by leading a dynamic team of Client Success Managers, driving customer satisfaction and retention while collaborating cross-functionally to maximize value from our solutions and in...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$185K - $256K *

Join a team that's redefining CMC strategies in life sciences. You'll engage with industry leaders, drive software adoption, and shape market narratives to enhance product lifecycle management and ope...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$192K - $240K *

Lead the charge in driving strategic people initiatives that enhance organizational effectiveness and performance within a high-growth sales environment. Collaborate with senior leadership to align ta...

RemoteRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$160K - $175K *

Shape the strategic vision for data products, leading a high-performing team to drive data-informed decisions and enhance product strategy. Collaborate cross-functionally to establish data governance...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$105K - $163K *

Lead and manage client-facing teams to deliver high-quality card processing projects, ensuring successful implementations and client satisfaction through effective project management and strategic ove...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $160K *

Lead the charge in overseeing finance and accounting operations, ensuring compliance and excellence in client service. Drive strategic growth while managing a team, innovating service offerings, and a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$150K - $205K *

Join a team that's driving M&A success by leading financial strategy, target evaluation, and integration planning. Collaborate with senior leaders to identify opportunities and execute critical phases...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $169K *

Transform customer outcomes by leading a high-performing team dedicated to leveraging Samsara's solutions. Drive strategic growth while ensuring enterprise clients realize sustained value from their i...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$85K - $95K *

Join a dynamic team as a strategic People Business Partner, advising leaders on talent strategy, change management, and employee relations. Drive engagement and organizational growth while fostering a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$161K - $273K *

Transform client relationships and drive revenue growth by leveraging deep industry expertise and consultative selling skills. Collaborate with teams to deliver tailored payment solutions and lead com...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$180K - $230K *

Grow your career with a leadership role overseeing global operations, focusing on strategy development, performance management, and cross-department collaboration to drive operational excellence and i...

RemoteRemote

Reposted 6 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$160K - $185K *

Join a dynamic team to drive growth by engaging mid-market employers, managing the full sales cycle, and fostering long-term partnerships. Collaborate with cross-functional teams to deliver innovative...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Transform your career by leading product development initiatives that enhance enterprise reporting and analytics. Collaborate with cross-functional teams to deliver high-quality solutions that meet bu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$119K - $186K *

Engage with health systems to drive strategic projects, enhance pharmacy solutions, and deliver impactful consulting services while mentoring and collaborating with clients to achieve transformative h...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Lead and advance the Operations Quality Assurance program, establishing standards and leveraging analytics and AI to drive performance improvements across teams while fostering talent development and...

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$183K - $220K *

Lead strategic initiatives for Integrated Delivery Networks and health systems, optimizing patient access and formulary adoption. Build executive relationships and drive clinical integration to enhanc...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$101K - $204K *

Unlock potential by leading the redesign of People Operations processes. Drive operational excellence through strategic assessments, workflow mapping, and implementation of innovative solutions that e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Lead the charge in enterprise sales by hunting new logos within the Life Sciences sector. Build relationships with Salesforce partners to enhance co-selling opportunities while managing your own pipel...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$91K - $121K *

Elevate the commercialization process across the product portfolio, enhancing efficiency and data integrity. Lead cross-functional collaboration, implement automation innovations, and drive strategic...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$215K - $239K *

Create transformative customer experiences and drive revenue growth across North America by leading market solutions teams, coaching talent, and navigating organizational change with clarity and effec...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$175K - $200K *

Lead the charge in developing integrated media strategies and client partnerships across pharmaceutical and life sciences accounts, driving business growth and ensuring exceptional delivery and client...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.