Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Director, 211 Manufacturing Quality and Regulatory Affairs
$190K - $228K *
Drive enterprise Quality and Regulatory governance for U.S. operations, ensuring compliance with FDA regulations and overseeing manufacturing quality in the therapeutic radiopharmaceutical sector whil...
Reposted 1 week ago
Regional Sales Manager, Federal System Integrators
$272K - $374K *
Empower our sales team to drive revenue growth by leading strategic engagements with Federal Systems Integrators. Utilize your expertise to craft account plans, build relationships, and navigate compl...
5 days ago
$110K - $130K *
Optimize procurement strategies to enhance cost, quality, and service. Lead a high-performing team, ensuring ethical practices and strong supplier relationships while collaborating across functions to...
2 weeks ago
Senior Director, Aftermarket Channel-North America
$176K - $220K *
Lead the charge in developing high-performing partnerships and teams to drive growth in North America's aftermarket channel, collaborating across functions to enhance partner performance and customer...
2 weeks ago
Sr. Director, Renewals Operations
$215K - $235K *
Unlock the future of commercial operations by leading integrated pricing, contract negotiations, and deal management for a $250M ARR business. Drive redesign initiatives, optimize processes with AI, a...
Reposted 3 weeks ago
$88K - $139K *
Transform customer partnerships by developing strategic growth initiatives, driving performance across categories, and ensuring profitable execution with expert cross-functional collaboration and data...
3 weeks ago
Territory Sales Manager (NC, VA, PA, or MD)
$100K - $120K *
Launch your career by creating demand for innovative wood fiber insulation. Drive sales, build relationships, and become a local expert in a new market. Your territory and earning potential are yours...
3 weeks ago
$110K - $130K *
Unlock potential by leading complex Aerospace and Defense programs, ensuring successful execution from contract award to delivery. Collaborate with cross-functional teams to meet customer expectations...
3 weeks ago
$100K - $120K *
Empower a high-performing sales team to drive revenue growth and exceed targets. Collaborate in a dynamic environment, coaching and inspiring talent while executing strategic sales plans for a global...
2 weeks ago
Sales Executive, Partnerships & Alliances - MLF
$136K - $253K *
Transform revenue growth by driving sales of partnership products to Mid Law High Value Accounts. Collaborate with territory owners and manage complex sales cycles while leveraging deep product knowle...
2 weeks ago
Instrument Sales Manager, Automated Solutions (Northeast Region)
$110K - $135K *
Champion automation sales by driving revenue growth and strategic alignment across regions. Collaborate closely with account managers, utilizing technical expertise to enhance customer relationships a...
3 weeks ago
Program Manager, HUB Operations
$88K - $105K *
Lead the management of pharmaceutical programs, ensuring client satisfaction and operational excellence. Oversee daily activities, supervise staff, and drive strategic planning while maintaining stron...
2 weeks ago
$150K - $180K *
Drive new-client acquisition by managing the full sales cycle, from prospecting to contract signing. Collaborate with marketing and commercial teams to deliver tailored solutions and build executive r...
1 week ago
$90K *
Join a team that champions success by leading multiple automotive centers, fostering employee engagement, enhancing customer experience, and driving operational excellence while ensuring profitability...
Reposted 1 week ago
$90K *
Champion customer and employee experiences as a District Manager overseeing multiple locations. Drive operational excellence and team motivation while ensuring profitability and adherence to key perfo...
Reposted 1 week ago
$90K *
Lead the charge in enhancing customer and employee experiences across multiple locations, driving profitability and team growth through effective management, strategic planning, and continuous improve...
Reposted 1 week ago
Vice President, Strategy & Business Development - Advanced Therapeutics Division
$280K - $481K *
Join a team that's driving growth in advanced therapeutics through strategic leadership, P&L accountability, and innovative business development. Shape the future of RNA oligonucleotide manufacturing...
1 week ago
Senior Manager, Regulatory Affairs
$120K - $145K *
Transform regulatory strategies for rare disease and cardio-pulmonary drug-device programs. Collaborate with cross-functional teams to ensure compliance and drive successful submissions globally, supp...
1 week ago
Senior Commercial Counsel, Revenue
$165K - $185K *
Help us drive growth by partnering with sales and business teams to streamline complex transactions. This role offers a unique opportunity to influence revenue operations and engage directly with clie...
2 weeks ago
21GRAMS- VP, Medical Strategy Director
$180K - $195K *
Elevate healthcare marketing by transforming complex science into impactful strategies. Lead multidisciplinary teams to inspire creativity, drive behavior change, and build trusted client relationship...
Reposted 1 week ago
$140K - $170K *
Shape the success of enterprise health systems by leading full implementations. Collaborate cross-functionally to manage project lifecycles, mitigate risks, and ensure smooth transitions to customer s...
4 weeks ago
Buick GMC District Sales Manager - Cape Girardeau
$90K - $110K *
Drive the future of automotive retail by partnering with dealerships to enhance performance, launch innovative technologies, and deliver exceptional customer experiences. This role requires strategic...
4 days ago
Account Executive, Partnerships
$80K - $110K *
Join a team that's driving growth by identifying and closing new client opportunities in experiential marketing. Leverage your network and expertise to engage youth and Gen Z through innovative campai...
2 weeks ago
National Account Manager, eCommerce
$123K - $181K *
Drive strategic growth by managing key ecommerce accounts, enhancing customer engagement, and executing omnichannel sales strategies. Collaborate cross-functionally to optimize performance and achieve...
2 weeks ago
National Account Manager, eCommerce
$123K - $181K *
Partner with us to drive omnichannel sales strategies and manage key eCommerce accounts. Lead customer relationships, execute growth initiatives, and collaborate cross-functionally to enhance customer...
2 weeks ago
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.