Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Director, Application Development Engineering
$146K - $269K *
Shape the future of enterprise software by leading multiple engineering teams, driving application development, and implementing best practices. Collaborate cross-functionally to enhance quality and s...
5 days ago
$110K - $130K *
Champion the development of AI-driven products, leading strategic initiatives and execution. Drive product roadmaps, manage budgets, and ensure alignment with business goals while delivering impactful...
4 days ago
Life Sciences Solutions Engineer, AVP (Commercialization)
$171K - $383K *
Accelerate progress at the forefront of AI-driven solutions in Life Sciences. Lead transformative commercial operations, drive client engagements, and innovate strategies to enhance data and analytics...
1 week ago
Life Sciences Solutions Engineer, AVP (Commercialization)
$171K - $383K *
Engage in transformative AI and data solutions for Life Sciences, leading commercial operations and driving innovation. Shape strategies, manage client relationships, and build high-performing teams t...
1 week ago
Sales Director - AI & Data Services
$160K - $200K *
Advance your career by driving new business growth across North America. Build strategic relationships with senior leaders in AI and technology, leading complex enterprise sales cycles and delivering...
3 weeks ago
Regional Director of Agent Channel - Atlanta
$110K - $130K *
Champion strategic partnerships and drive revenue growth through effective channel management and collaborative business planning, ensuring sales success and partner satisfaction while navigating comp...
Reposted today
Product Line Manager Foodservice
$100K - $120K *
Shape the future of food solutions by managing product lines to drive growth, optimize profitability, and align market opportunities with operational capabilities through strategic initiatives and cro...
3 days ago
$150K - $180K *
Transform the Federal landscape by leading enterprise sales efforts, engaging with SES leaders, and driving digital transformation across major accounts. Collaborate with cross-functional teams to ach...
5 days ago
$125K - $150K *
Champion the development of a go-to-market strategy for South Asia, focusing on client acquisition and market expansion. Engage with diverse stakeholders to drive growth and innovation in media produc...
1 week ago
$84K - $109K *
Shape the future of advertising by managing a portfolio of mid-market CPG brands, driving strategic partnerships, and delivering data-driven insights to enhance client growth and revenue on a leading...
3 weeks ago
Senior Sales Operations Transformation & Managed Services Leader
$132K - $245K *
Elevate Sales Operations by leading transformation initiatives, optimizing processes, and implementing AI-driven solutions to enhance efficiency and drive revenue growth. Collaborate with clients to r...
6 days ago
$80K - $175K *
Lead the charge in driving sales performance and team accountability. Engage directly with agents, manage leads, and foster a high-energy environment to maximize conversions and team growth while ensu...
3 weeks ago
Sr. Director, Strategy & Execution
$160K - $200K *
Transform the future of go-to-market strategy by leading cross-functional teams, driving execution governance, and shaping long-range plans to achieve growth objectives in a dynamic, global environmen...
4 weeks ago
$115K - $145K *
Engage in the development and delivery of innovative training programs that enhance the skills and performance of sales teams in the pharma/biotech sector, ensuring alignment with strategic goals and...
4 weeks ago
Senior Director, NA Field Marketing
$160K - $190K *
Drive impactful multi-channel field marketing strategies that enhance demand generation, strengthen customer relationships, and optimize pipeline performance. Lead a high-performing team while collabo...
5 days ago
Regional Account Manager - Central
$87K - $105K *
Shape the future of regional sales by developing strategic relationships within retail markets, expanding business opportunities, and positioning the company as the preferred environmental services pa...
Reposted 2 weeks ago
$80K - $95K *
Join a team that's driving renewable energy solutions by cultivating client relationships and generating new business through a consultative sales approach. Collaborate with operations to deliver tail...
1 week ago
$90K - $110K *
Grow your career with a dynamic team focused on generating new business in the public sector. Utilize a consultative sales approach to build relationships and deliver tailored solutions, driving reven...
1 week ago
$105K - $130K *
Join a dynamic team to lead multiple client engagements, driving innovative solutions and strategic direction. Foster cross-functional collaboration in a fast-paced environment with a focus on deliver...
Reposted 2 weeks ago
$125K - $150K *
Join us to drive growth in enterprise accounts, owning the full sales cycle from prospecting to closing. Collaborate with a dynamic team to convert leads into revenue while leveraging market insights...
1 week ago
$90K - $110K *
Develop and implement strategic business initiatives to drive growth, expand market presence, and foster partnerships. Lead cross-functional teams to achieve long-term objectives while identifying new...
1 week ago
$125K - $150K *
Join us in empowering enterprise organizations by driving sales of our innovative software platform. Leverage your consultative sales skills to build lasting relationships and help clients enhance the...
3 weeks ago
$110K - $130K *
Partner with us to drive transformative healthcare solutions by managing key accounts, fostering relationships, and ensuring measurable outcomes. Your expertise will enhance provider partnerships and...
1 week ago
Product Manager - Wellness and Social Health
$86K - $138K *
Lead the charge in defining and executing a comprehensive product strategy, driving value across product portfolios. Collaborate with key stakeholders to align strategic vision while overseeing perfor...
Reposted 5 days ago
$160K - $200K *
Drive investor relations by cultivating institutional partnerships, managing client expectations, and executing complex transactions in the renewable energy sector. Collaborate with teams to align str...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.