Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$95K - $150K *
Drive your career forward by providing tailored security solutions to small businesses. Collaborate with owners to understand their needs, customize systems, and cultivate lasting relationships while...
Today
Sr. Director, Regional Sales, West - Intismeran
$196K - $353K *
Join us to lead the West Region Oncology Sales team, driving strategy and execution for a groundbreaking mRNA therapy. Collaborate with partners, build relationships, and ensure launch excellence whil...
2 weeks ago
Business Operations Project Manager
$100K - $120K *
Drive customer success by managing complex onboarding projects, ensuring alignment across teams, and delivering high-quality implementations. This role is pivotal in creating structured processes in a...
4 weeks ago
$200K - $250K *
Champion innovative financing strategies to drive growth in a dynamic energy infrastructure company. Oversee capital funding, asset finance, and deal design while building a high-performing finance te...
4 weeks ago
Strategic Account Executive - TOLA
$340K *
Elevate your career by driving strategic sales in the TOLA region. Collaborate with cross-functional teams to build relationships, uncover opportunities, and deliver value through innovative SaaS solu...
2 weeks ago
Executive Underwriter, Central
$150K - $190K *
Lead the charge in underwriting and managing complex enterprise accounts, driving profitable business through strategic broker partnerships while mentoring junior underwriters and shaping portfolio st...
2 weeks ago
Sales Engineer - Mid Market - West
$109K - $128K *
Empower industries by bridging cutting-edge IoT technology with operational excellence. Collaborate across teams to drive customer success while enhancing logistics, safety, and sustainability through...
Reposted 2 days ago
$87K - $109K *
Transform public-sector auction services by building relationships with key decision-makers. Drive business growth through strategic outreach, presentations, and consultative selling, ensuring long-te...
1 week ago
Account Executive, Existing Customers
$160K - $220K *
Engage with higher education institutions to foster relationships, drive customer success, and expand platform adoption. Balance strategic management and revenue growth in a dynamic environment, ensur...
4 weeks ago
$95K - $115K *
Elevate customer engagement by leading SaaS renewal strategies, fostering relationships, and driving growth through negotiation and operational excellence in a dynamic environment...
Reposted 3 days ago
$82K - $131K *
Join a team that's driving sales success in the retail sector! Manage a dynamic territory, develop strategic sales campaigns, and build lasting relationships with enterprise customers while leveraging...
Reposted 5 days ago
Director Product Market Development
$135K - $160K *
Advance your career by driving market intelligence and product strategy for RUO oncology and transplant products. Collaborate with cross-functional teams to enhance customer relationships and ensure s...
2 weeks ago
$105K - $120K *
Empower healthcare professionals by engaging remotely with cardiologists, nephrologists, and primary care providers. Drive sales and support efforts in open territories while delivering a consistent e...
Reposted today
Vice President Human Resources
$200K - $250K *
Unlock potential by leading HR strategies across 12 manufacturing sites and a remote workforce. Drive high-volume hiring, simplify processes, and foster a proactive culture to support rapid growth and...
3 weeks ago
$145K - $175K *
Join a team that's redefining legal operations in a fast-paced healthtech environment. As a key player, you'll manage complex contracts, drive compliance, and leverage technology to enhance efficiency...
Today
Supervisor, Program Management
$80K - $95K *
Join a team that's dedicated to operational excellence and employee development. As a Supervisor, you'll lead daily operations, manage performance, and ensure compliance while fostering a collaborativ...
1 week ago
Lead Business Development Representative I
$100K - $120K *
Elevate the customs product landscape in Mexico by leading strategic initiatives, driving customer acquisition, and collaborating with cross-functional teams to enhance operational efficiency and mark...
3 weeks ago
Sales Executive, Lending Solutions
$133K - $227K *
Join our dynamic team to drive sales of innovative commercial lending solutions. Leverage your expertise in complex sales to build relationships and exceed targets, while collaborating with cross-func...
4 weeks ago
Regional Operations Director, Florida Market
$110K - $130K *
Unlock potential by leading regional operations across multiple venues, driving revenue growth, talent development, and guest experience. This role demands strategic oversight, accountability, and a c...
4 weeks ago
Inside Sales Representative II
$63K - $120K *
Drive revenue growth by managing high-volume sales interactions, building lasting client relationships, and exceeding performance metrics. Own your results in a fast-paced environment while leveraging...
6 days ago
$95K - $115K *
Join a team that's redefining product marketing by driving impactful go-to-market strategies, enabling sales teams, and translating complex product features into clear customer value across diverse ma...
5 days ago
Vice President, CMC Development and Drug Delivery Innovation
$272K - $340K *
Join a team that's driving CMC strategy and execution for innovative therapies. Lead cross-functional efforts in drug and device development, ensuring compliance and operational excellence from clinic...
2 weeks ago
$100K - $120K *
Champion the Accounts Payable function by optimizing processes, enhancing compliance, and driving automation. Collaborate cross-functionally to deliver insights and support enterprise goals in a fast...
Today
Hybrid Sales Representative - South Central
$90K - $93K *
Empower your career by driving sales and customer engagement through hybrid interactions with healthcare professionals. Build relationships, deliver compliant education, and execute strategic plans to...
Today
Hybrid Sales Representative - South Central
$90K - $93K *
Drive sales performance and customer engagement through virtual and in-person interactions with healthcare professionals. Build relationships, deliver compliant education, and execute strategic activi...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.