Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$110K - $130K *

Lead the charge in driving revenue growth across a multistate territory by managing a team of Dealer Representatives. Oversee sales operations, strategic direction, and relationship building to achiev...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Lead the charge in monitoring transactional risk for banking and treasury services, ensuring effective fraud detection and credit risk management across multiple program layers while driving resolutio...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$119K - $186K *

Transform the future of supply chain technology by leading innovation initiatives, managing a structured evaluation process, and engaging stakeholders to drive measurable value and strategic alignment...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Grow your career by managing strategic accounts, driving revenue, and fostering long-term relationships. Leverage expertise in solution selling and account management to deliver customer-centric strat...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$66K - $111K *

Engage and lead a team of sales representatives to enhance productivity, drive customer service excellence, and foster strong client relationships while managing multiple priorities for impactful busi...

3 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$66K - $111K *

Drive success by leading a team of sales representatives and merchandisers to enhance customer service and marketplace execution while fostering strong relationships and improving business performance...

3 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$140K - $160K *

Champion growth in public safety sales by leading a dynamic team, forging strategic partnerships, and driving revenue across North America. Leverage your expertise to enhance market presence and deliv...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$75K - $125K *

Drive growth and dealer loyalty by implementing strategic sales initiatives, enhancing customer relationships, and ensuring year-over-year sales increases in your territory while collaborating with cr...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$147K - $184K *

Shape the future of sales operations by analyzing performance metrics, driving strategic initiatives, and leading cross-functional projects to enhance efficiency and productivity in the SMB sector. Jo...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$201K - $251K *

Lead strategic forecasting initiatives to drive decision-making in oncology. Collaborate with cross-functional teams to develop long-term models and communicate insights that shape product and portfol...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Shape strategic sales initiatives targeting Fortune 2000 accounts. Drive complex sales cycles, engage with C-suite leaders, and leverage AI solutions to meet revenue goals while building a robust pipe...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Drive growth by building and scaling credit card acquisition channels through innovative affiliate partnerships, targeted paid search, and social programs, while collaborating with cross-functional te...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $140K *

Drive organizational success by partnering with field leaders to align workforce strategies, enhance talent development, and manage workplace resolutions, ensuring effective staffing and engagement ac...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Technical Services

$91K - $141K *

Empower agency growth by managing relationships and driving performance in Nebraska and Kansas. Lead strategic initiatives, deliver training, and ensure accountability to achieve sales goals while fos...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $150K *

Transform the future of business development by building strategic partnerships across key professional services. Drive growth through relationship-building and co-closing deals, while shaping a natio...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$150K - $180K *

Drive strategic initiatives and operational excellence across a global portfolio, partnering with leadership to enhance business performance and deliver measurable outcomes in oncology and rare diseas...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$144K - $189K *

Unlock potential by leading product innovation in clinical genomics. Shape tools for case management and data workflows, ensuring efficiency and quality while collaborating with lab directors and engi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $112K *

Shape compelling product narratives by leveraging market insights and AI tools. Collaborate cross-functionally to drive go-to-market strategies, ensuring impactful messaging and training materials tha...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $135K *

Elevate vendor sales through strategic partnerships, driving growth and profitability. Foster relationships with vendor teams, enable partner success, and align on revenue goals to enhance market pres...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $150K *

Drive sales growth by building strong vendor relationships and enabling partners. You'll align with internal teams to deliver impactful solutions, ensuring swift onboarding and maximizing revenue thro...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$185K - $210K *

Engage with clients to drive retention and growth strategies, fostering deep relationships and collaboration across teams. Leverage market insights to enhance product offerings and ensure client succe...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Champion the growth of our commercial engine by leading business development efforts, forging strategic partnerships, and driving revenue as quantum computing transitions to enterprise applications. C...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $153K *

Optimize strategic partnerships by managing consultant relationships, driving engagement, and aligning insights with business goals to enhance client retention and sales effectiveness while fostering...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $115K *

Drive the evolution of contact center technologies by coordinating cross-functional initiatives, aligning stakeholders, and enhancing operational effectiveness to improve customer experience and achie...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$201K - $251K *

Join us to lead cross-functional project management in a dynamic biotech environment. Drive global commercialization initiatives, ensuring alignment and execution across teams while enhancing operatio...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.