Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$109K - $207K *

Champion the future of Experience Management in Life Sciences by driving strategic growth, cultivating C-suite relationships, and leading complex negotiations to enhance patient outcomes and operation...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Unlock potential by bridging business and technical teams to define and implement master data management and governance solutions, ensuring data quality and compliance across the organization...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $130K *

Elevate your career by leading innovative geochemical projects in mining. Collaborate with multidisciplinary teams to deliver impactful solutions, mentor emerging professionals, and drive business dev...

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$159K - $235K *

Champion advanced detection engineering to enhance threat identification capabilities. Collaborate with Protective Services to develop and optimize detection systems, integrating diverse data sources...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$90K - $124K *

Unlock potential by driving sales and fostering relationships with customers. Assess their environmental needs and deliver tailored solutions while expanding service offerings to maximize growth and r...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$110K - $130K *

Shape the future of procurement by leading strategic sourcing initiatives, enhancing vendor relationships, and driving financial transparency. Collaborate across teams to streamline processes and leve...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $110K *

Discover your potential by supporting data-driven decision-making as you develop and implement advanced statistical and machine learning models. Collaborate with stakeholders and enhance your skills i...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$141K - $195K *

Take ownership of cost accounting and procure-to-pay processes, driving inventory valuation and COGS analysis. Collaborate with cross-functional teams to enhance methodologies and ensure compliance, w...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Join a team that's redefining HR technology! Lead the design and management of our Workday system, collaborating across departments to enhance HR and Payroll processes through innovative solutions and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Inspire healthcare excellence by providing expert pharmacy consulting, educating patients on medication use, and ensuring safety through compliance. Collaborate with a dedicated team to deliver clinic...

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Drive patient-centered pharmacy services by providing expert consultations, educating on medication use, and ensuring safety through compliance. Mentor team members while delivering clinical healthcar...

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$112K - $165K *

Elevate your career by driving enterprise sales, building strategic relationships, and modernizing financial operations for global businesses. Partner with C-suite leaders to enhance their payment sol...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$78K - $126K *

Transform public safety operations by aligning technology solutions with customer needs. Collaborate in a dynamic team to implement an industry-leading SaaS platform, enhancing mission-critical workfl...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$88K - $147K *

Inspire and elevate employee engagement through strategic internal communications. Collaborate with leaders to craft and deliver impactful messaging that drives understanding of company goals and fost...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$135K - $155K *

Join a team that's shaping the future of enterprise sales in the US. Drive the go-to-market strategy, close deals with major clients, and build a high-performing sales organization from the ground up...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Champion the maintenance and optimization of Oracle databases in AWS, ensuring system integrity and performance. Collaborate with teams to implement solutions, manage configurations, and support compl...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Champion new business growth by driving customer acquisition in the payments sector. Engage with financial institutions to modernize their payment solutions, leveraging your expertise to create strate...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Join a team that's dedicated to fostering a safe online community. Oversee daily operations, manage a support team, and develop policies to ensure user safety and satisfaction while collaborating acro...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Transform clinical trial expertise into impactful project delivery. Oversee research integrity, lead cross-functional teams, and promote operational excellence to ensure successful trial execution wit...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Elevate sales growth in the refrigeration and HVAC/R sectors by driving market development, building key relationships, and implementing effective strategies to maximize customer engagement and produc...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$65K - $96K *

Shape the future of wholesale sales by driving revenue growth, expanding relationships, and uncovering new opportunities. Leverage your expertise to manage pipelines, forecast accurately, and achieve...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$146K - $206K *

Transform the user experience by designing and implementing innovative financial products. Collaborate in a dynamic team to enhance the checkout platform, ensuring reliability and performance for seam...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Elevate payroll operations by ensuring accurate processing for 10,000+ employees. Leverage technology and collaborate with cross-functional teams to enhance efficiency and deliver exceptional service...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$141K - $189K *

Join a dynamic team to drive strategic growth within the Department of Veterans Affairs, leveraging your expertise to build relationships, execute account strategies, and navigate complex procurement...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$84K - $130K *

Unlock the potential of marketing automation and insights by designing innovative data strategies, mentoring teams, and integrating AI solutions to enhance targeting and efficiency across marketing in...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.