Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$105K - $110K *

Unlock your potential as you drive strategic growth in K-12 special education markets. Lead complex sales cycles, build trusted relationships, and shape innovative solutions that enhance educational o...

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  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$142K - $224K *

Join a dynamic team as you engage with oncology stakeholders, educate on products, and drive sales growth in a diverse territory. Collaborate with colleagues to enhance customer experiences and achiev...

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  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$173K - $272K *

Lead the charge in ensuring quality oversight for contract testing laboratories globally, implementing policies and managing performance to meet regulatory standards while safeguarding patient safety...

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  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $190K *

Deliver innovative solutions by acquiring Fortune 500 clients, leading complex sales cycles, and building executive relationships. Drive value through AI insights and strategic partnerships, ensuring...

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  •   11 - 15 years exp.  •   Enterprise Technology

$90K - $105K *

Advance your career by leading a dedicated team in delivering trauma-informed care for substance use disorders. Shape clinical practices and foster a supportive environment in a new clinic focused on...

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  •   Less than 5 years exp.  •   Healthcare

$100K *

Grow your career by driving business development in the leasing real estate sector. Engage with property management firms to sell essential support services, manage full sales cycles, and foster lasti...

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  •   Less than 5 years exp.  •   Real Estate & Construction

$164K - $225K *

Develop and execute patient advocacy strategies, engaging with PAOs and cross-functional teams to elevate the patient voice and ensure successful partnerships for rare disease therapeutic areas...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Optimize strategic opportunities by leading cross-functional initiatives and applying AI-driven solutions to enhance business performance, while collaborating with senior leaders to drive impactful ch...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$107K - $171K *

Shape the market narrative for AI Agent Identity by leading product marketing initiatives. Own positioning, messaging, and commercial enablement for DNSid, translating complex innovations into compell...

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  •   8 - 10 years exp.  •   Information Technology

$137K - $219K *

Elevate IT operations by orchestrating complex initiatives, driving user adoption, and optimizing delivery processes. Serve as the key liaison among technical teams and business stakeholders to ensure...

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Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$138K - $163K *

Drive the evolution of software solutions for healthcare quality reporting, leading engineering teams to deliver innovative, high-quality products while fostering a culture of collaboration and contin...

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  •   5 - 7 years exp.  •   Healthcare

$150K - $200K *

Lead client engagements by leveraging tax expertise to drive revenue growth, manage complex planning discussions, and enhance client relationships while ensuring strategic alignment across teams for o...

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  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $200K *

Lead a dynamic team of Equipment Sales Specialists to drive sales growth, enhance customer satisfaction, and innovate equipment offerings in the dental sector while collaborating with cross-functional...

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  •   Less than 5 years exp.  •   Healthcare

$79K - $102K *

Champion customer success by guiding Mid-Market clients through the deployment and adoption of IoT solutions, ensuring they maximize value from our technology while building strong relationships acros...

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  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Drive strategic insights by analyzing cross-functional data to enhance decision-making. Collaborate with teams to build a trusted business intelligence framework, delivering actionable recommendations...

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  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Unlock the potential of seamless data exchange by analyzing EDI requirements, developing maps, and supporting integrations. Collaborate with partners to ensure efficient transactions and enhance elect...

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  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Join a team that's focused on driving growth in Healthcare and Financial Services. Leverage your enterprise sales expertise to build relationships, develop new business, and deliver impactful technolo...

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  •   8 - 10 years exp.  •   Enterprise Technology

$87K - $114K *

Lead the charge in fraud prevention by analyzing data, assessing risks, and collaborating with teams to enhance fraud protection strategies across the organization. Drive impactful change through exec...

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  •   5 - 7 years exp.  •   Finance & Insurance

$83K - $116K *

Partner with us to drive business development in home improvement financing, fostering relationships with contractors and sponsors. Leverage your expertise to identify opportunities, enhance CRM proce...

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  •   5 - 7 years exp.  •   Finance & Insurance

$87K - $180K *

Inspire customer loyalty and retention by managing the entire lifecycle for government and enterprise accounts. Collaborate cross-functionally to enhance product adoption, resolve issues, and drive ac...

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  •   Less than 5 years exp.  •   Transportation

$133K - $171K *

Shape the future of digital video strategy by leading CTV initiatives, optimizing performance, and fostering innovation. Collaborate with teams to connect audience insights with client goals, ensuring...

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  •   8 - 10 years exp.  •   Media

$90K - $250K *

Accelerate your career by driving new business in the SLED sector. Own your territory, build strategic relationships, and deliver innovative IT solutions with support from top-tier engineering teams a...

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  •   Less than 5 years exp.  •   Information Technology

$105K - $150K *

Lead product management for complex digital services, mentoring a team of Product Managers. Collaborate with stakeholders to define strategies, prioritize needs, and deliver impactful outcomes while f...

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  •   5 - 7 years exp.  •   Enterprise Technology

$145K - $175K *

Deliver innovative datacenter, cloud, and network solutions by leading architecture design, client engagement, and technical governance. Collaborate with cross-functional teams to shape complex infras...

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  •   8 - 10 years exp.  •   Information Technology

$180K - $250K *

Tackle systemic challenges by building tools and practices that enhance performance, scalability, and decision-making across engineering teams, fostering collaboration and driving solutions that bridg...

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  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.