Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $121,112
Pharmacy Operations Optimization Manager - KitCheck
$110K - $125K *
Shape the future of pharmacy operations by optimizing customer engagement and operational performance across a national portfolio. Drive proactive interventions and enhance workflow efficiency to ensu...
1 week ago
Privacy Program Optimization Manager - PrivacyPro
$110K - $125K *
Elevate customer engagement by optimizing privacy program performance across a diverse portfolio. Ensure proactive intervention and support for healthcare privacy teams, driving compliance and enhanci...
1 week ago
Channel Account Manager, Partner Sales - VAR Channel
$85K - $114K *
Transform the Value-Added Reseller ecosystem by leveraging channel expertise to drive growth, engaging partners, and developing robust strategies for customer acquisition and revenue expansion within...
Reposted 1 week ago
Sales Manager - Edge Platforms
$500K+*
Accelerate progress at driving new enterprise sales for AI platforms, owning the full sales cycle from prospecting to closing. Engage with CXOs across key industries to deliver measurable business out...
1 week ago
Senior Customer Marketing Manager
$145K - $185K *
Engage the customer lifecycle by developing scalable marketing programs that enhance onboarding, retention, and expansion. Collaborate cross-functionally to transform insights into impactful strategie...
1 week ago
Hematology Therapeutic Specialist (South Texas)
$110K - $130K *
Champion the growth of hematology products by educating healthcare providers, driving demand, and fostering relationships within cancer centers. Leverage cross-functional teams to ensure a positive ex...
1 week ago
$115K - $130K *
Analyze market trends and performance metrics to drive actionable insights across marketing, sales, and revenue operations. Collaborate with cross-functional teams to optimize strategies and enhance g...
1 week ago
Actuarial Director - Remote (Seattle, WA)
$220K - $240K *
Lead the development of client data strategies and actuarial studies, ensuring accurate financial projections and effective communication with clients. Collaborate with teams to optimize health benefi...
Reposted 1 week ago
$150K - $163K *
Join a dynamic Solutions Architecture team to tackle complex technology challenges, drive customer success, and enhance product offerings across diverse industries. Your expertise will shape outcomes...
1 week ago
$103K - $173K *
Drive strategic planning and financial forecasting for NAM field services, ensuring accurate insights and alignment with global standards. Collaborate with cross-functional teams to enhance operationa...
1 week ago
Director of Property Accounting
$140K - $165K *
Shape the future of property accounting by leading a dynamic team, ensuring timely financial reporting, and driving innovative processes that enhance client trust and operational efficiency across mul...
1 week ago
Customer Marketing Manager, Retention & Advocacy
$95K - $115K *
Empower customer retention and advocacy by leading US-focused programs. Collaborate cross-functionally to enhance customer journeys, ensuring clear communication and value delivery while optimizing en...
1 week ago
Customer Journey Operations Manager
$120K - $150K *
Accelerate customer journey operations by driving scalable processes and systems. Collaborate cross-functionally to enhance customer success, technical support, and partner engagement, ensuring effici...
1 week ago
Senior Medical Science Liaison, South (Multiple Territories)
$190K - $220K *
Engage with key stakeholders as a Senior Medical Science Liaison, driving prelaunch and launch strategies. Build trusted relationships, deliver scientific insights, and influence adoption in a dynamic...
1 week ago
$111K - $145K *
Lead transformative IT projects from inception to completion, ensuring timely delivery and budget adherence. Collaborate across departments to translate business needs into actionable plans while mana...
1 week ago
Senior Software Engineer - Virtual Machines (RD222)
$125K - $150K *
Transform your career by owning complex software features that integrate virtual machines into a secure platform. Collaborate across teams to deliver innovative solutions while establishing strong eng...
1 week ago
Principal Solution Architect - Security
$165K - $231K *
Transform complex security challenges into innovative solutions for public-sector and commercial clients. Lead technical pre-sales efforts, collaborating with sales teams to deliver tailored architect...
1 week ago
$160K - $185K *
Unlock your potential by leading a dynamic team to drive channel partnerships, transforming opportunities into revenue-generating relationships across diverse verticals in a fast-growing ecosystem...
1 week ago
$165K - $195K *
Engage in strategic solution development for Federal Government initiatives, translating client needs into innovative technical strategies. Collaborate with cross-functional teams to deliver compellin...
1 week ago
$105K - $132K *
Join a team that's dedicated to optimizing employee benefits programs. You'll manage US benefits operations, enhance vendor performance, and shape global strategies, ensuring a seamless, employee-cent...
1 week ago
Hematology Therapeutic Specialist (LA North)
$110K - $130K *
Join a team that's dedicated to advancing hematology care by educating healthcare providers and driving demand for innovative therapies. Leverage your expertise to foster relationships and ensure a po...
1 week ago
D&T Sr Project Management Consultant - Talent Community
$110K - $130K *
Elevate your project management career by leading a strategic platform within investor client coverage, enhancing client engagement and driving technology integration across CBRE's commercial real est...
Reposted 1 week ago
Oil & Gas/Chemical Segment Leader
$119K - $190K *
Deliver strategic growth in the Oil & Gas and Chemical sectors by identifying opportunities, building executive relationships, and enabling sales. Leverage industry expertise to shape market strategie...
1 week ago
$80K - $130K *
Lead dealership implementations by managing go-lives, training teams, and ensuring seamless integrations. Collaborate with stakeholders to optimize workflows and drive adoption, while traveling freque...
1 week ago
$100K - $120K *
Advance global clinical trials by leading cross-functional teams, ensuring compliance and operational excellence while managing timelines and budgets to deliver impactful results in Oncology research...
1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.