Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$209K - $273K *

Drive innovation by owning customer-facing products end to end, leading technical strategy, and shaping product direction. Collaborate across teams to build AI-native experiences that enhance user eng...

RemoteRemote

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  •   8 - 10 years exp.  •   Information Technology

$115K - $125K *

Drive a vibrant EHS culture through strategic leadership and collaboration. Empower stakeholders with expert guidance, ensure compliance, and elevate safety standards across all operations in a dynami...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Transportation

$66K - $99K *

Unlock potential by providing compassionate care to individuals facing substance use and mental health challenges. Join a dedicated team committed to making a difference in the community through excep...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $125K *

Lead innovative design solutions as a Senior Design Engineer, transforming client needs into actionable broadcast system designs. Collaborate with global teams, mentor junior engineers, and ensure pro...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Hospitality & Recreation

$205K - $240K *

Shape the future of supply chain technology by leading engineering teams in optimizing platforms for logistics and order management. Drive innovation and efficiency while managing a diverse team of ex...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$90K - $120K *

Join a team that's driving innovation in AI and automation solutions across retail. Collaborate with cross-functional teams to develop, deploy, and support enterprise-level applications that enhance m...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$107K - $144K *

Manage tax compliance engagements, ensuring timely service and proactive client communication. Lead a team, review tax work, and maintain expertise in high net worth individual tax matters while drivi...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $130K *

Join a team that's dedicated to advancing global studies in Neurology, Psych, and Rare Disease. Lead project teams, manage operations, and ensure timely delivery to exceed client expectations while ac...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$129K - $162K *

Unlock potential by leading enterprise-wide Cost of Care solutions. Drive scalability, optimize deployment, and enhance operational effectiveness across diverse markets, collaborating with stakeholder...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$224K - $431K *

Champion the advancement of open-source Linux kernel support for NVIDIA GPUs. Collaborate with global teams to develop virtualization features in Rust and C, driving technical proposals and enhancing...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$150K - $235K *

Join a team that's redefining business processes through digital transformation. Lead cross-functional initiatives, ensuring scalable and standardized practices that align with strategic goals while f...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Drive the end-to-end revenue lifecycle and lead a high-performing team in optimizing order-to-cash operations. Collaborate cross-functionally to ensure compliance with ASC 606 while enhancing automati...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$100K - $120K *

Join a dynamic team to drive sales of AI solutions to community banks and credit unions. Manage the full sales cycle, from pipeline generation to closing, while exceeding quotas in a fast-paced, high...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$102K - $163K *

Lead the charge in designing and overseeing digital instrumentation and control systems, ensuring compliance with industry regulations while coordinating workflows and schedules with subcontractors to...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Energy & Utilities

$75K - $100K *

Reimagine talent acquisition by leading full-cycle recruiting efforts, collaborating with leadership to forecast hiring needs, and enhancing employer branding to attract top talent while ensuring comp...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$103K - $181K *

Transform user experiences by developing and enhancing frontend applications using JavaScript, React, and TypeScript. Collaborate in an Agile environment to deliver high-quality software solutions whi...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$88K - $154K *

Analyze and enhance compensation strategies, ensuring competitive and compliant practices. Collaborate with HR and management to optimize job descriptions, conduct market analysis, and deliver insight...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Real Estate & Construction

$115K - $130K *

Join a team that's shaping financial strategy and operations. Oversee budgeting, forecasting, and reporting while mentoring staff and driving team performance. Your leadership will enhance efficiency...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Real Estate & Construction

$100K - $152K *

Unlock your potential by designing high-voltage transmission lines, leading project teams, and collaborating with clients. Utilize your engineering expertise to drive innovative solutions and mentor j...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Technical Services

$110K - $130K *

Drive business growth by leading end-to-end capture efforts in cybersecurity and intelligence sectors. Engage customers, shape strategies, and close deals while owning the full lifecycle of opportunit...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$150K - $200K *

Lead high-impact client delivery operations, ensuring quality execution and resource optimization across diverse projects. Collaborate with cross-functional teams to drive performance and enhance cust...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$106K - $127K *

Drive strategic insights as a Senior Business Intelligence Analyst, transforming complex data into actionable solutions. Collaborate across teams to enhance decision-making, optimize processes, and le...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$144K - $184K *

Join an innovative engineering team to transform product delivery through AI-driven development, ensuring high standards and compliance while combining product, design, and engineering leadership acro...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$132K - $232K *

Redefine career mobility strategies by integrating talent marketplace capabilities, enabling associates to explore growth opportunities through data-informed solutions and collaborative practices acro...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Empower institutions by delivering tailored ERP solutions in financial aid, optimizing processes, and ensuring compliance. Collaborate with stakeholders to enhance student services and drive strategic...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.