Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Vice President, Clinical Operations
$200K - $250K *
Make your mark at the forefront of clinical operations, driving global studies from strategy to execution while ensuring operational integration across teams and vendors for successful Phase 3 program...
1 month ago
$95K - $115K *
Elevate financial operations by overseeing budgeting, forecasting, and reporting. Collaborate with leadership to drive strategic insights and strengthen compliance while mentoring a dynamic finance te...
1 week ago
Technical Program Manager (TPM)
$115K - $145K *
Engineer innovative systems and processes to enhance product delivery, ensuring cross-functional teams operate efficiently and effectively. Drive execution, manage stakeholder alignment, and facilitat...
2 weeks ago
Senior Manager, Distribution & Revenue Strategy
$120K - $160K *
Drive strategic initiatives across partnerships, revenue, and operations. Collaborate with cross-functional leaders to tackle complex challenges in a fast-paced environment, ensuring effective executi...
Today
Sr. Account Manager - Renewals/Expansion
$140K - $175K *
Join a dynamic team as you drive renewals and expansion for managed sales customers. Leverage executive relationships and strategic planning to enhance account growth while collaborating with cross-fu...
3 days ago
Corporate Charge Capture Auditor, Outpatient
$63K - $101K *
Optimize compliance in Interventional Radiology charge capture by conducting audits, educating teams, and enhancing coding practices. Collaborate with clinical departments to identify and rectify codi...
3 weeks ago
Technology Operations Director
$180K - $210K *
Transform technology operations by leading strategic initiatives, enhancing cybersecurity, and fostering cross-functional collaboration to support mission-driven projects and a remote-first workforce...
1 week ago
$81K - $102K *
Join a team that's dedicated to ensuring compliance and risk management across partner offices. You'll oversee adherence to policies, foster relationships, and support training initiatives while manag...
Reposted 1 week ago
Business Development Manager - Acute
$95K - $115K *
Grow your career by driving revenue growth in the acute care market through new customer acquisition and account expansion. Manage the full sales lifecycle while collaborating with internal teams to d...
Today
$80K - $95K *
Take ownership of payroll and equity accounting processes, ensuring accuracy and compliance with GAAP. Collaborate with cross-functional teams and lead process improvements while maintaining documenta...
Reposted 2 weeks ago
Sr Director, Partnership & Business Development
$160K - $200K *
Join a team that's redefining partnerships in the automotive SaaS space. Lead strategic initiatives to enhance our developer ecosystem, drive commercial negotiations, and foster innovation across key...
Today
$90K - $120K *
Drive revenue growth by optimizing systems and processes across Marketing, Sales, and Customer Success. Leverage data to enhance operational efficiency and establish HubSpot as a reliable source of tr...
6 days ago
Senior Manager, Supply Chain 1
$108K - $130K *
Champion the development of Planning and Inventory strategies, leading a team to optimize supply chain performance and ensure compliance. Drive process improvements and manage supplier relationships t...
Reposted 2 days ago
$70K - $110K *
Join a team that's dedicated to supporting disaster recovery efforts. Collaborate with leadership and clients to navigate complex recovery operations, ensuring effective management of multi-billion do...
Reposted yesterday
Director or Senior Director of Translational Medicine
$235K - $310K *
Join a team that empowers translational medicine innovation in early-phase oncology, owning strategies from IND-enabling studies to proof of concept. Drive impactful biomarker integration and clinical...
Reposted 1 week ago
Sr. Manager, Regional Accounts
$110K - $140K *
Transform regional accounts by developing strategic programs and building strong relationships with local decision-makers. Drive growth through effective budgeting, insights, and innovative solutions...
2 weeks ago
$110K - $130K *
Strategize and lead complex technical analysis to bridge business needs with IT solutions, ensuring compliance and efficiency across enterprise operations while mentoring teams and driving continuous...
Yesterday
Director of Pricing - GovCon exp required - Services NOT Products (Job 1485)
$170K - $185K *
Champion pricing strategy and lead a dynamic team to develop competitive, compliant pricing for complex U.S. Government opportunities, directly influencing organizational success and growth in federal...
3 weeks ago
GVP, Global Partners, Alliances and Channels
$280K - $290K *
Transform partner strategies to build robust alliances and channels globally. Drive growth by developing and managing partnerships while ensuring alignment with corporate objectives and enabling great...
Reposted 3 weeks ago
Associate Director, Marketing, Lung Patient
$186K - $233K *
Shape impactful marketing strategies for lung cancer programs, collaborating with cross-functional teams to drive patient engagement and launch readiness. Lead initiatives that align with brand goals...
2 days ago
$180K - $212K *
Drive growth through innovative demand generation strategies, leveraging data and analytics to enhance pipeline performance. Collaborate with cross-functional teams to optimize marketing efforts and l...
6 days ago
Section Chief, Abdominal / Body Imaging
$300K - $350K *
Transform your career by leading a national body imaging service line, optimizing workflows, and enhancing clinical quality standards while mentoring a dedicated team of radiologists across multiple l...
1 week ago
$104K - $174K *
Unlock potential by driving client engagement and delivering tailored solutions. Collaborate with cross-functional teams to enhance client experiences, manage complex projects, and present insights to...
3 weeks ago
Revenue Lifecycle Marketing Manager
$95K - $115K *
Optimize customer engagement through strategic lifecycle marketing programs that enhance onboarding, adoption, and retention. Collaborate cross-functionally to drive measurable revenue growth and impr...
2 weeks ago
$80K - $95K *
Lead the design and delivery of impactful training programs, creating engaging learning materials and facilitating sessions to enhance employee skills and knowledge across various business units. Driv...
Today
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.