Explore $100K+ Jobs in California

Discover professional opportunities across California with Ladders. From established business centers to growing regional economies, the state offers senior-level roles in technology, healthcare, finance, entertainment, manufacturing, and more. Browse vetted job listings with salaries of $100,000 or higher and find positions that align with your experience and career goals.

California industries and career opportunities

California’s diverse economy supports leadership and specialized roles at companies of all sizes. Depending on your background, you may find opportunities in software and technology, life sciences, healthcare, financial services, clean energy, media, aerospace, and professional services. Job availability and compensation vary by role, employer, and location.

Find jobs throughout the state

Explore openings in major employment centers such as Los Angeles, San Francisco, San Diego, San Jose, Sacramento, and surrounding communities. Listings may include on-site, hybrid, and remote arrangements; review each posting for its work location and requirements.

Search with Ladders

Use Ladders to focus your search on vetted professional jobs paying $100,000 or more. Review role responsibilities, qualifications, compensation details, and workplace expectations, then apply directly to opportunities that fit your goals. Keep your profile and resume current so employers can better understand your experience.

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1,000+

Jobs in California

Average Salary in USD

Average Salary: $142,597

Sort By: Relevance

$121K - $205K *

Join a team that's redefining manufacturing excellence by leading pressure decay leak test systems. You'll drive design, validation, and optimization processes, ensuring compliance and reliability acr...

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$121K - $205K *

Lead the charge in optimizing pressure decay leak test systems across manufacturing lines. As a subject matter expert, you'll ensure compliance and reliability in testing processes, driving continuous...

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $105K *

Lead the development and execution of a comprehensive physical security strategy, ensuring the safety of personnel and assets across multiple facilities while managing security operations and complian...

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $230K *

Lead the design and integration of cutting-edge SoC architectures, driving subsystem development and PPA optimization. Collaborate across teams to deliver innovative solutions that meet customer needs...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$170K - $230K *

Join a team that's redefining SoC design by owning subsystem development, integrating third-party IP, and optimizing PPA for next-gen architectures. Contribute across all design stages and drive impac...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Drive sales performance by managing comprehensive compensation strategies that align with company goals. Collaborate across teams to design and implement effective plans, analyze data trends, and ensu...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Staffing

$120K - $145K *

Join a dynamic team to develop cutting-edge perception algorithms for detection, tracking, and classification in challenging environments. Collaborate on AI and ML methods to enhance real-time perform...

3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$95K - $115K *

Lead the charge in developing innovative analytical instruments, collaborating with cross-functional teams to ensure product feasibility, manufacturability, and compliance. Drive projects from concept...

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$145K - $177K *

Elevate machine learning capabilities by enhancing RL infrastructure and integrating innovative technologies, driving efficiency and reliability in a cutting-edge environment focused on autonomous dri...

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$112K - $125K *

Transform user experiences by configuring and optimizing conversational AI solutions. Collaborate with stakeholders to design workflows, integrate systems, and enhance performance through data analysi...

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$174K - $255K *

Transform your career by leading strategic digital growth initiatives that enhance customer engagement and drive revenue. Shape product strategies across diverse channels, leveraging insights to creat...

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$93K - $104K *

Empower residents by delivering high-quality occupational therapy services, implementing tailored treatment plans, and collaborating with interdisciplinary teams to enhance functional skills and promo...

3 days ago

  •   Less than 5 years exp.  •   Business Services

$155K - $165K *

Oversee and enhance internal controls and SOX compliance, leading a team to assess risks, design controls, and ensure effective financial reporting. Collaborate with cross-functional partners to drive...

3 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$122K - $143K *

Innovate regulatory operations by managing submission preparation and execution, ensuring compliance with FDA and ICH standards. Collaborate cross-functionally to support complex filings and maintain...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$84K - $114K *

Join a team that's dedicated to enhancing patient care in the Angio/IR lab. Utilize your skills to assist in procedures, monitor vital data, and ensure a well-prepared environment while contributing t...

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Drive revenue growth by managing key customer relationships and delivering accurate forecasts. Collaborate with teams to support product development and ensure compliance with industry standards while...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Engage top-tier accounts by developing strategic relationships and navigating complex sales processes. Drive seven-figure deals through effective account planning and collaboration with internal teams...

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $190K *

Lead the development and implementation of global regulatory strategies, ensuring compliance and market approval for products. Collaborate with cross-functional teams to mitigate risks and drive regul...

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Join a team that's pivotal in managing contract requests, ensuring compliance, and streamlining workflows. You'll coordinate with legal teams, maintain contract records, and support operational metric...

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$133K - $183K *

Innovate reliability engineering strategies that enhance product integrity, optimize design processes, and ensure compliance with industry standards while leading quality assurance initiatives across...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$125K *

Play a key role in providing clinical leadership and oversight for nursing services, ensuring compliance with regulations and quality standards while supporting field nurses and enhancing care for ind...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $125K *

Champion optimal living by leading nursing teams and ensuring quality care for assisted living and memory care residents. Collaborate with management to enhance resident well-being and compliance with...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $190K *

Deliver high-impact project management for heavy civil and transit work. Oversee project lifecycles from estimating to execution, ensuring compliance, budget control, and safety standards while foster...

Reposted 3 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $180K *

Transform biological challenges into solutions by leveraging advanced AI and machine learning. Collaborate with a multidisciplinary team to design and deploy innovative models that enhance biosecurity...

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $120K *

Shape the future of air traffic control tower construction by managing project documentation, schedules, and subcontractor coordination. Collaborate with senior team members to ensure timely procureme...

3 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in California?question toggle

    California listings may include senior and specialized roles in technology, healthcare, finance, life sciences, entertainment, clean energy, manufacturing, and other fields. Available positions depend on current employer needs.

  • Where in California can I search for jobs?question toggle

    You can explore opportunities across the state, including major employment hubs such as Los Angeles, San Francisco, San Diego, San Jose, and Sacramento. Check each posting for its specific location and work arrangement.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review each listing for compensation information and details, since pay can vary by position and employer.

  • Can I find remote or hybrid California jobs?question toggle

    Some listings may offer remote or hybrid work, while others require on-site work. The job posting provides the employer’s location and work arrangement requirements.

  • How can I improve my California job search?question toggle

    Narrow your search by role, location, industry, and work arrangement. Keep your resume and profile updated, and carefully compare each opportunity’s qualifications and compensation details.