Explore $100K+ Jobs in California

Discover professional opportunities across California with Ladders. From established business centers to growing regional economies, the state offers senior-level roles in technology, healthcare, finance, entertainment, manufacturing, and more. Browse vetted job listings with salaries of $100,000 or higher and find positions that align with your experience and career goals.

California industries and career opportunities

California’s diverse economy supports leadership and specialized roles at companies of all sizes. Depending on your background, you may find opportunities in software and technology, life sciences, healthcare, financial services, clean energy, media, aerospace, and professional services. Job availability and compensation vary by role, employer, and location.

Find jobs throughout the state

Explore openings in major employment centers such as Los Angeles, San Francisco, San Diego, San Jose, Sacramento, and surrounding communities. Listings may include on-site, hybrid, and remote arrangements; review each posting for its work location and requirements.

Search with Ladders

Use Ladders to focus your search on vetted professional jobs paying $100,000 or more. Review role responsibilities, qualifications, compensation details, and workplace expectations, then apply directly to opportunities that fit your goals. Keep your profile and resume current so employers can better understand your experience.

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1,000+

Jobs in California

Average Salary in USD

Average Salary: $142,597

Sort By: Relevance

$120K - $135K *

Empower patients by delivering exceptional home health care as a Registered Nurse Case Manager. Collaborate with interdisciplinary teams to create and implement personalized care plans, ensuring welln...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$140K - $160K *

Manage comprehensive patient care plans, oversee nursing staff, and ensure effective coordination for home health patients, driving wellness and minimizing re-hospitalization through leadership and cl...

Reposted yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$75K - $91K *

Lead a dynamic team in providing high-level administrative support to executive staff, ensuring efficient operations and effective communication within the Police Department. Collaborate on budget man...

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$62K - $114K *

Accelerate progress at the forefront of technology by assembling and validating advanced sensing and compute payloads. Collaborate with engineers to enhance build processes and ensure reliability in b...

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $110K *

Elevate client relationships and drive strategic media integration across multiple business lines. Lead a dedicated team, optimize performance analytics, and manage workflows to deliver impactful camp...

Yesterday

  •   5 - 7 years exp.  •   Media

$188K *

Champion the advancement of STEM education by leading program development, fostering innovation, and enhancing student success through strategic planning and collaboration with faculty and community p...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$180K - $210K *

Drive operational excellence as you oversee security event management, ensuring compliance and quality service delivery while collaborating with clients and internal teams to enhance program efficienc...

Yesterday

  •   Less than 5 years exp.  •   Staffing

$85K - $89K *

Champion your career by leading HR initiatives that align with business goals. Oversee staffing, employee relations, and training while fostering a positive workplace culture and ensuring compliance w...

Yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$134K - $201K *

Champion identity governance by engineering robust access controls and automation. Collaborate across teams to ensure secure, compliant identity management for all users and systems, enhancing enterpr...

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$150K - $155K *

Unlock potential by driving AI and automation solutions to enhance operational efficiency and employee experience. Collaborate across departments to identify challenges and implement impactful improve...

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$120K - $175K *

Pioneer insights at the intersection of Sales, Marketing, and CS by owning and enhancing analytical infrastructure to generate decision-ready insights that drive growth in a dynamic, fast-paced enviro...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$129K - $231K *

Reimagine drug discovery as you lead molecular pharmacology efforts in neuroscience. Collaborate across teams to develop strategies, interpret data, and advance innovative therapies for sleep-wake dis...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$75K - $90K *

Unlock potential by guiding clients on their financial journeys, building lasting relationships, and leveraging a supportive network to achieve personal and professional success in a flexible, collabo...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $105K *

Join a specialized team to evaluate biological research, ensuring safety against misuse. Utilize your expertise to distinguish legitimate science from potential threats, contributing to AI safety and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$135K - $160K *

Join a dynamic team to architect and implement a next-gen Design System, ensuring consistent, accessible experiences across products. Collaborate with cross-functional teams to drive technical alignme...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Food & Beverages

$86K - $138K *

Take ownership of complex contract management activities, leading the full contract life cycle while mentoring staff and collaborating across departments to enhance compliance and process efficiency...

Yesterday

  •   5 - 7 years exp.  •   Transportation

$105K - $140K *

Pioneer the communications strategy for a national Torch Relay, engaging diverse stakeholders and leading crisis management to ensure a cohesive message throughout this historic event...

Yesterday

  •   5 - 7 years exp.  •   Hospitality & Recreation

$130K - $155K *

Empower your career by leading the Aircraft Engineering team in developing and certifying innovative connectivity systems for commercial aircraft, ensuring compliance with regulatory standards while f...

California, USRemote

Yesterday

  •   11 - 15 years exp.  •   Telecommunications & Hardware

$201K - $251K *

Elevate access strategies and marketing initiatives for oncology products, focusing on non-clinical value propositions. Collaborate cross-functionally to ensure successful product launches and effecti...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$75K - $180K *

Deliver innovative biddable media strategies, optimize client campaigns, and lead a dynamic team to drive growth and performance across diverse digital channels ultimately enhancing business outcomes...

Reposted yesterday

  •   5 - 7 years exp.  •   Media

$186K - $233K *

Bring your expertise to lead strategic marketing initiatives in oncology, collaborating with cross-functional teams to drive impactful campaigns and launch strategies that enhance patient care and mar...

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$133K - $162K *

Manage the planning and optimization of the Countywide ERP system, ensuring effective HR and payroll support across departments. Lead governance, enhance functionality, and align technology with busin...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$81K - $176K *

Empower organizational growth by driving talent management strategies, enhancing leadership pipelines, and ensuring effective succession planning across the enterprise. Collaborate with stakeholders t...

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

$211K - $264K *

Unlock potential by leading global CMC regulatory strategies for clinical development and marketing authorization. Drive high-quality submissions and collaborate with cross-functional teams to ensure...

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$255K - $424K *

Lead the development and execution of Immunology access services strategy, ensuring seamless patient and provider experiences. Collaborate cross-functionally to enhance reimbursement initiatives and d...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in California?question toggle

    California listings may include senior and specialized roles in technology, healthcare, finance, life sciences, entertainment, clean energy, manufacturing, and other fields. Available positions depend on current employer needs.

  • Where in California can I search for jobs?question toggle

    You can explore opportunities across the state, including major employment hubs such as Los Angeles, San Francisco, San Diego, San Jose, and Sacramento. Check each posting for its specific location and work arrangement.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review each listing for compensation information and details, since pay can vary by position and employer.

  • Can I find remote or hybrid California jobs?question toggle

    Some listings may offer remote or hybrid work, while others require on-site work. The job posting provides the employer’s location and work arrangement requirements.

  • How can I improve my California job search?question toggle

    Narrow your search by role, location, industry, and work arrangement. Keep your resume and profile updated, and carefully compare each opportunity’s qualifications and compensation details.