Explore $100K+ Jobs in California

Discover professional opportunities across California with Ladders. Browse vetted roles with salaries of $100,000 or more, from established employers and growing companies. Whether you’re looking for a leadership position or your next specialized role, find opportunities that match your experience and career goals.

Career opportunities across California

California’s broad economy offers roles in fields such as technology, entertainment, healthcare, finance, biotechnology, clean energy, and professional services. Opportunities can be found in major employment centers including Los Angeles, San Francisco, San Diego, San Jose, Sacramento, and other communities throughout the state. Job availability and compensation vary by employer, location, role, and qualifications.

Find roles that fit your experience

Use job details to compare responsibilities, required skills, work arrangements, and compensation. Search for positions by title, industry, or location, and review each listing for its specific salary range and requirements. Tailor your resume to highlight relevant results, expertise, and leadership experience when applying.

Search California jobs on Ladders

Ladders focuses on vetted professional jobs paying $100,000 or more. Explore California listings to identify opportunities aligned with your background, preferred location, and next career move. Listings change frequently, so check back for newly available roles.

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1,000+

Jobs in California

Average Salary in USD

Average Salary: $142,595

Sort By: Relevance

$187K - $253K *

Pioneer market strategies and lead a team of Specialty Account Managers to drive sales growth in the Neurology space, ensuring effective execution and resource management while fostering a collaborati...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$89K - $121K *

Join a team that's dedicated to transforming patient care by providing clinical insights and driving product utilization among healthcare professionals in a dynamic sales environment. Your expertise w...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Champion strategic workforce planning and AI-driven work design to enhance capability, improve productivity, and advance internal mobility across teams. Drive tools and strategies aligning workforce p...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$285K - $385K *

Lead regulatory due diligence for clinical/commercial assets, assessing risks and strategies for licensing, acquisitions, and partnerships. Collaborate across teams to ensure regulatory integration in...

RemoteRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$189K - $246K *

Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $145K *

Grow your career with a pivotal role leveraging data to combat fraud. Collaborate across teams to analyze complex datasets, develop strategies, and enhance decision-making processes, driving impactful...

Reposted yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$140K - $220K *

Transform the reliability landscape by engineering robust systems and architecting foundational services that empower multiple product teams, ensuring seamless scaling and outstanding performance for...

Reposted yesterday

  •   8 - 10 years exp.  •   Information Technology

$140K - $220K *

Unlock insights by designing and building data systems that drive product decisions. Collaborate across teams to deliver actionable analytics, ensuring data-driven choices that enhance user experience...

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$145K - $220K *

Shape the future of Finance by managing AI transformation initiatives, collaborating with stakeholders to identify high-value use cases, and ensuring successful integration of AI solutions within Fina...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Information Technology

$92K - $120K *

Lead innovative structural solutions as a Project Engineer, tackling complex design challenges, mentoring junior engineers, and enhancing project delivery through collaboration and effective communica...

Yesterday

  •   Less than 5 years exp.  •   Real Estate & Construction

$80K - $95K *

Elevate your career by managing clinical sites and ensuring study quality, patient safety, and regulatory compliance. Collaborate with site teams to support enrollment and deliver impactful clinical r...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $140K *

Manage quality control processes across multiple disciplines, ensuring compliance with standards and regulations. Lead a team, conduct inspections, and implement quality assurance measures to support...

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$77K - $83K *

Provide exceptional customer service by addressing inquiries and resolving issues for exhibitors and show management, ensuring a seamless event experience through effective communication and coordinat...

Yesterday

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$121K - $170K *

Lead the transformation of storage solutions by leveraging deep technical expertise in NetApp Keystone and Storage-as-a-Service. Collaborate with customers to architect tailored solutions that optimiz...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$105K - $150K *

Champion your career as you lead data engineering initiatives, ensuring successful project implementation and high client satisfaction. Collaborate with teams to transform analytics data into actionab...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$91K - $128K *

Join a team that's dedicated to empowering educators through impactful training sessions. You'll create engaging content and deliver customized Google for Education engagements, enhancing customer rel...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Engineer innovative design solutions by collaborating across disciplines to create functional prototypes. Utilize advanced fabrication techniques and iterative methodologies to transform concepts into...

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$136K - $181K *

Drive innovation by optimizing Clinical Operations through digital solutions, enhancing productivity across clinical trial phases while ensuring stakeholder collaboration and strategic alignment with...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$176K - $236K *

Lead the charge in global regulatory project management, driving oncology strategies and submissions across regions. Collaborate with cross-functional teams to ensure compliance and timely market acce...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$114K - $154K *

Transform supply chain operations by managing SAP systems and processes, ensuring seamless logistics and distribution support. Drive efficiency and issue resolution across Commercial and Clinical Supp...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$178K - $238K *

Drive impactful oncology drug development by leading program management, optimizing team efficiency, and ensuring strategic alignment across global projects to enhance patient outcomes and organizatio...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$75K - $130K *

Join us to produce and deliver engaging sports stories on air, leveraging your editorial strengths, writing skills, and on-camera presence in a fast-paced news environment to capture the audience's at...

Reposted yesterday

  •   Less than 5 years exp.  •   Media

$97K - $165K *

Shape the future of cloud solutions by leading technical relationships, validating AWS architectures, and driving presales strategies. Empower teams through mentorship while ensuring secure, scalable...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Business Services

$121K - $206K *

Lead the charge in architecting and delivering Microsoft Azure and 365 solutions for SMBs. Oversee cloud migrations, security implementations, and project management while fostering strong partner rel...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Business Services

$158K - $270K *

Lead the charge in defining product strategy and roadmap for AI-enabled global support, optimizing customer experiences and operational scale in a dynamic, transformative role driven by executive visi...

Reposted yesterday

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in California?question toggle

    California listings may include senior and specialized roles in technology, healthcare, finance, biotechnology, entertainment, clean energy, and other industries. Available positions depend on current employer hiring needs.

  • Which California cities have professional job opportunities?question toggle

    Opportunities may be listed in Los Angeles, San Francisco, San Diego, San Jose, Sacramento, and other cities and regions across the state. Search by location to see current openings.

  • Do all jobs listed in California pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Review each listing for its specific compensation details, since salary ranges and terms can vary.

  • How can I find a California job that matches my experience?question toggle

    Search by job title, location, or industry, then compare each listing’s responsibilities and qualifications with your background. Highlight relevant skills and measurable accomplishments in your application.

  • Are remote or hybrid California jobs available?question toggle

    Some employers may offer remote or hybrid arrangements, while others require on-site work. Check each job listing for its work location and arrangement.