Explore $100K+ Jobs in California

Discover professional opportunities across California with Ladders. From established business centers to growing regional economies, the state offers senior-level roles in technology, healthcare, finance, entertainment, manufacturing, and more. Browse vetted job listings with salaries of $100,000 or higher and find positions that align with your experience and career goals.

California industries and career opportunities

California’s diverse economy supports leadership and specialized roles at companies of all sizes. Depending on your background, you may find opportunities in software and technology, life sciences, healthcare, financial services, clean energy, media, aerospace, and professional services. Job availability and compensation vary by role, employer, and location.

Find jobs throughout the state

Explore openings in major employment centers such as Los Angeles, San Francisco, San Diego, San Jose, Sacramento, and surrounding communities. Listings may include on-site, hybrid, and remote arrangements; review each posting for its work location and requirements.

Search with Ladders

Use Ladders to focus your search on vetted professional jobs paying $100,000 or more. Review role responsibilities, qualifications, compensation details, and workplace expectations, then apply directly to opportunities that fit your goals. Keep your profile and resume current so employers can better understand your experience.

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1,000+

Jobs in California

Average Salary in USD

Average Salary: $142,597

Sort By: Relevance

$140K - $192K *

Collaborate with our Neurology TBM team to drive demand generation and support successful product launches. Engage healthcare professionals and coordinate strategies to meet sales objectives while pri...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $192K *

Champion growth in our Neurology Franchise by driving demand and supporting product launches. Collaborate with healthcare professionals and internal teams to exceed sales objectives while maintaining...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$136K - $187K *

Unlock potential by serving as a vital resource for patients and caregivers, providing education and support for managing generalized Myasthenia Gravis while coordinating treatment and navigating insu...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $192K *

Drive success by collaborating with healthcare professionals to launch and promote neurology products. Leverage local market insights and teamwork to exceed sales objectives while maintaining a patien...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$168K - $231K *

Join a dynamic team to lead Nurse Case Managers, enhancing patient support and education throughout treatment journeys while ensuring compliance and quality in case management processes...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$108K - $196K *

Optimize clinical quality and cost-effectiveness of drug rebates through data analysis and operational management, collaborating with account teams to enhance performance and achieve financial goals f...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$60K - $100K *

Drive client satisfaction by managing operations, onboarding, and relationships. Collaborate across teams to ensure service excellence and timely project delivery while addressing complex client needs...

San Diego, CARemote

Today

  •   Less than 5 years exp.  •   Healthcare

$83K - $145K *

Transform client operations by delivering innovative business systems solutions. Collaborate with stakeholders to integrate technology and processes, ensuring timely service and continuous improvement...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$134K - $176K *

Lead the development and execution of a national supplier quality program, ensuring compliance and fostering strong supplier relationships to enhance operational efficiency and project success across...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$85K - $111K *

Join a team that drives procurement excellence by sourcing electrical equipment and construction materials. Manage vendor relationships and optimize purchasing strategies to align with corporate objec...

Today

  •   Less than 5 years exp.  •   Real Estate & Construction

$95K - $153K *

Join a team that's shaping the future of construction technology by driving product innovation and enhancing user experiences. Collaborate with stakeholders to prioritize features and ensure successfu...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$82K - $122K *

Manage the outerwear product line by strategizing seasonal plans, driving cross-functional collaboration, and ensuring successful go-to-market execution to meet consumer needs and achieve profitable g...

Today

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Unlock potential by evaluating and executing commercial real estate investments, gaining exposure to sourcing, underwriting, and closing across diverse property types and strategies in a collaborative...

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$167K - $282K *

Lead the charge in shaping global EHS3 strategy, ensuring compliance and operational excellence across diverse functions while driving transformational initiatives and enterprise governance frameworks...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Business Services

$92K - $102K *

Join a team that's dedicated to delivering high-quality client projects. As a Project Manager, you'll oversee project lifecycles, ensuring timelines are met while fostering strong client relationships...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$159K - $227K *

Elevate your career by leading enzyme discovery and development initiatives. Utilize your expertise in biochemistry and analytical chemistry to drive innovative research, mentor teams, and solve compl...

Reposted today

  •   8 - 10 years exp.  •   Food & Beverages

$100K - $120K *

Shape educational strategies and support for wound care, enhancing customer engagement and product implementation across key accounts while collaborating with internal teams to drive clinical excellen...

Today

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$95K - $115K *

Unlock potential by delivering expert education and consultation in wound care. Collaborate with key accounts to enhance product conversions and support customer needs while traveling extensively acro...

Today

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$95K - $115K *

Empower your career by delivering impactful education and support in wound care. Collaborate with healthcare professionals to enhance patient outcomes and drive product conversions while managing key...

Today

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$84K - $103K *

Join a team dedicated to excellence in service delivery through effective supervision, training, and client care documentation, ensuring adherence to legal and ethical standards while fostering commun...

Reposted today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$74K - $131K *

Empower recruitment excellence by leading strategic campaigns nationwide, building strong partnerships, and enhancing team performance. Drive impactful initiatives while adapting to diverse recruitmen...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $130K *

Unlock growth in the food and nutraceutical sector by managing customer relationships, executing sales strategies, and driving market analysis to achieve sales goals and foster sustainable business de...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$165K - $170K *

Join a team that's transforming business strategy into people strategy. As a senior advisor, you'll partner with leaders to enhance organizational effectiveness, drive talent decisions, and ensure ali...

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $115K *

Drive impactful analytics by designing and maintaining Power BI dashboards, leveraging SQL expertise to extract insights from complex datasets, and applying insurance knowledge to enhance reporting so...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Business Services

$70K - $110K *

Partner with us to conduct detailed IRF audits and validate payment integrity, leveraging your clinical knowledge to ensure compliance with documentation and reimbursement standards in a collaborative...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in California?question toggle

    California listings may include senior and specialized roles in technology, healthcare, finance, life sciences, entertainment, clean energy, manufacturing, and other fields. Available positions depend on current employer needs.

  • Where in California can I search for jobs?question toggle

    You can explore opportunities across the state, including major employment hubs such as Los Angeles, San Francisco, San Diego, San Jose, and Sacramento. Check each posting for its specific location and work arrangement.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review each listing for compensation information and details, since pay can vary by position and employer.

  • Can I find remote or hybrid California jobs?question toggle

    Some listings may offer remote or hybrid work, while others require on-site work. The job posting provides the employer’s location and work arrangement requirements.

  • How can I improve my California job search?question toggle

    Narrow your search by role, location, industry, and work arrangement. Keep your resume and profile updated, and carefully compare each opportunity’s qualifications and compensation details.