Explore $100K+ Jobs in California

Discover professional opportunities across California with Ladders. From established business centers to growing regional economies, the state offers senior-level roles in technology, healthcare, finance, entertainment, manufacturing, and more. Browse vetted job listings with salaries of $100,000 or higher and find positions that align with your experience and career goals.

California industries and career opportunities

California’s diverse economy supports leadership and specialized roles at companies of all sizes. Depending on your background, you may find opportunities in software and technology, life sciences, healthcare, financial services, clean energy, media, aerospace, and professional services. Job availability and compensation vary by role, employer, and location.

Find jobs throughout the state

Explore openings in major employment centers such as Los Angeles, San Francisco, San Diego, San Jose, Sacramento, and surrounding communities. Listings may include on-site, hybrid, and remote arrangements; review each posting for its work location and requirements.

Search with Ladders

Use Ladders to focus your search on vetted professional jobs paying $100,000 or more. Review role responsibilities, qualifications, compensation details, and workplace expectations, then apply directly to opportunities that fit your goals. Keep your profile and resume current so employers can better understand your experience.

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1,000+

Jobs in California

Average Salary in USD

Average Salary: $142,597

Sort By: Relevance

$100K - $120K *

Advance your career by leading digital content strategies that enhance brand visibility and drive eCommerce success. Collaborate with cross-functional teams to create engaging content that resonates w...

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Join a vibrant culinary team as you drive menu innovation, lead with creativity, and oversee high-volume operations. Inspire collaboration and deliver exceptional dining experiences across multiple ou...

Reposted today

  •   Less than 5 years exp.  •   Hospitality & Recreation

$285K - $310K *

Lead the strategic execution of global clinical trials, ensuring adherence to timelines, budgets, and quality standards while fostering collaboration across teams and mentoring Clinical Operations per...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$229K - $260K *

Transform the integration landscape by architecting robust connections between NodeZero and key security platforms, ensuring reliability and observability while mentoring engineers and driving technic...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$130K - $160K *

Innovate finance transformation by automating workflows and integrating data systems. Collaborate with cross-functional teams to enhance reporting and streamline operations, ensuring a single source o...

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $100K *

Elevate your career by delivering exceptional design experiences and driving sales growth. Engage clients through personalized consultations, master product knowledge, and create stunning mood boards...

Today

  •   Less than 5 years exp.  •   Real Estate & Construction

$95K - $115K *

Engineer customer reliability by providing expert technical support for IoT solutions. Collaborate with teams to resolve issues, enhance documentation, and gather feedback, ensuring a seamless custome...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Join a team that's revitalizing relationships and driving growth in Northern California. Lead and mentor a diverse sales team while collaborating with funeral home owners to unlock potential and achie...

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$195K - $364K *

Pioneer new business growth and ensure top-level performance through strategic regional management of commercial banking teams, relationships, and profitability initiatives for long-term success...

Reposted today

  •   11 - 15 years exp.  •   Finance & Insurance

$162K - $221K *

Unlock potential by leading advanced practice providers in pediatric care. Oversee operational management, drive quality initiatives, and enhance care delivery across cardiology and CT surgery, ensuri...

Today

  •   5 - 7 years exp.  •   Healthcare

$87K - $161K *

Launch your career by designing and implementing AI-driven security solutions that enhance automation and reduce repetitive tasks. Collaborate across teams to build robust, secure applications and str...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$114K - $165K *

Transform patient care in a dynamic PICU environment, collaborating with a multidisciplinary team to deliver exceptional support for critically ill children and young adults. Your expertise will shape...

Today

  •   Less than 5 years exp.  •   Healthcare

$122K - $212K *

Lead national account strategies for corporate customers in MedTech, fostering executive relationships and driving growth through strategic partnerships and cross-functional collaboration to enhance p...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$173K - $299K *

Join a leading neuroscience team as a scientific expert driving strategic planning and development. Collaborate across functions to ensure regulatory compliance and scientific excellence from discover...

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$91K - $147K *

Take ownership of production operations by supervising teams, driving process improvements, and fostering collaboration. Utilize Lean and Six Sigma methodologies to enhance efficiency and ensure opera...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$75K - $106K *

Inspire operational excellence by translating production plans into detailed schedules. Collaborate with cross-functional teams to optimize resources, enhance efficiency, and ensure timely delivery of...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$75K - $120K *

Drive continuous improvement in manufacturing processes and systems. Collaborate cross-functionally to enhance efficiency, safety, and quality. Execute engineering projects while developing problem-so...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$109K - $174K *

Lead and execute clinical trials in compliance with regulations and timelines, handling everything from study design to data review. Collaborate with teams to ensure successful project delivery and ad...

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$117K - $201K *

Help us elevate patient care as a Medical Science Liaison, driving scientific exchange and relationship-building with key healthcare leaders in Hematology. You will be integral in strategizing medical...

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$117K - $201K *

Join a dedicated team to shape innovative medical solutions. As a key expert, engage healthcare professionals, foster scientific collaboration, and drive impactful insights to enhance patient care and...

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$117K - $201K *

Unlock potential by driving scientific engagement and collaboration with key health care professionals in a dynamic medical landscape, enhancing relationships, generating insights, and ensuring compli...

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$117K - $201K *

Unlock potential by joining a dynamic team as a Medical Science Liaison, where you'll drive scientific engagement, cultivate key relationships, and provide valuable insights to healthcare professional...

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$117K - $201K *

Drive scientific exchange and develop relationships with KOLs in hematology, ensuring high-quality insights align with medical strategy. Pioneer innovative approaches, staying informed on treatment tr...

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$94K - $164K *

Champion user experience design across digital products, driving insights into actionable solutions. Collaborate with cross-functional teams to enhance customer journeys and ensure alignment with Huma...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$94K - $164K *

Champion cost reporting processes by ensuring data accuracy, preparing detailed reports, and analyzing financial information. Collaborate across departments to enhance reporting systems and support st...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in California?question toggle

    California listings may include senior and specialized roles in technology, healthcare, finance, life sciences, entertainment, clean energy, manufacturing, and other fields. Available positions depend on current employer needs.

  • Where in California can I search for jobs?question toggle

    You can explore opportunities across the state, including major employment hubs such as Los Angeles, San Francisco, San Diego, San Jose, and Sacramento. Check each posting for its specific location and work arrangement.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review each listing for compensation information and details, since pay can vary by position and employer.

  • Can I find remote or hybrid California jobs?question toggle

    Some listings may offer remote or hybrid work, while others require on-site work. The job posting provides the employer’s location and work arrangement requirements.

  • How can I improve my California job search?question toggle

    Narrow your search by role, location, industry, and work arrangement. Keep your resume and profile updated, and carefully compare each opportunity’s qualifications and compensation details.