Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Project Executive - Mission Critical Construction
$150K - $180K *
Lead the charge in managing large-scale data center projects, ensuring profitability, client satisfaction, and team performance while overseeing safety, quality, and risk management throughout the pro...
Today
$224K - $282K *
Lead the charge in transforming new business sales, driving revenue growth, and shaping go-to-market strategies while managing a high-performing team and collaborating across departments to enhance cu...
3 weeks ago
Corporate Finance Manager, Fundraising and Investor Relations
$133K - $166K *
Champion the fundraising efforts of a dynamic corporate finance team, managing complex debt and equity processes while collaborating with senior leadership to craft compelling narratives for investors...
2 weeks ago
$110K - $130K *
Engage your expertise to lead bridge and structural projects from planning to completion. Manage multidisciplinary teams, maintain client relationships, and drive practice growth across Massachusetts...
2 weeks ago
$80K - $95K *
Empower the CDL program by leading training initiatives, ensuring compliance, and optimizing fleet management. Collaborate with regional leaders to enhance operational efficiency and drive revenue gro...
1 week ago
Senior Technical Account Manager
$110K - $130K *
Contribute to customer success as a technical liaison, driving adoption of AI-driven solutions while collaborating with cross-functional teams to enhance product value and performance. Foster strong r...
Reposted 4 weeks ago
Enterprise AI Architecture Director
$122K - $338K *
Transform enterprise AI strategies by owning methodologies, technical perspectives, and asset portfolios. Collaborate with sales leadership and engage in high-stakes client interactions to drive impac...
1 week ago
Key Account Manager - Dallas, TX
$170K - $205K *
Transform sales strategies by driving key account growth, building relationships, and executing plans for a new kidney transplant product. Collaborate cross-functionally to ensure optimal market acces...
4 weeks ago
$220K - $245K *
Join us in overseeing regulatory affairs activities, developing strategies for clinical trials, and managing global submissions to ensure compliance and product approvals in a dynamic pharmaceutical e...
4 days ago
$80K - $95K *
Lead our Rehab Team to enhance the lives of older adults by supervising staff, managing therapy activities, and ensuring optimal patient outcomes in a collaborative environment...
2 days ago
VP, Relationship Manager - Industrial
$125K - $150K *
Advance your career by driving strategic vendor finance relationships in the industrial equipment sector. Lead business development efforts, manage key partnerships, and deliver tailored financing sol...
2 weeks ago
Director, HR Business Partner - Corporate Functions
$119K - $190K *
Shape the future of our Corporate Functions by partnering with senior leaders to drive talent strategy, organizational effectiveness, and leadership development. Leverage data and insights to influenc...
5 days ago
$138K - $165K *
Elevate our product management efforts by driving innovation in cybersecurity. Collaborate with cross-functional teams to deliver impactful data-driven analytics, leveraging user insights and industry...
Reposted 2 weeks ago
Project Manager- Government Services
$88K - $105K *
Join a team that's dedicated to managing federal construction projects, ensuring quality and efficiency through estimating, scheduling, and collaboration with government representatives and design tea...
2 weeks ago
$100K - $120K *
Lead the monthly close and day-to-day accounting operations, ensuring accuracy and efficiency as the business scales. Collaborate with cross-functional teams to enhance processes and implement automat...
1 week ago
Portal Product Owner - Life and Annuity Business Unit
$87K - $224K *
Join a team that's redefining digital experiences in the life and annuities sector. Lead product management for our innovative portal platform, collaborating with cross-functional teams to enhance use...
5 days ago
Director, Sourcing & Procurement
$190K - $237K *
Optimize sourcing strategies and procurement processes for clinical operations, ensuring effective vendor management and governance across global clinical trials. Collaborate with cross-functional tea...
2 weeks ago
$133K - $262K *
Unlock potential by developing AI-driven solutions that enhance business processes and integrate with enterprise systems. Collaborate with clients and teams to shape the future of finance and accounti...
Yesterday
$85K - $110K *
Collaborate with cross-functional teams to manage ETF fund administration, ensuring compliance with SEC regulations while preparing financial statements and regulatory filings. Adapt to evolving prior...
Today
$130K - $145K *
Champion data privacy across jurisdictions by providing expert advice, managing compliance, and supporting initiatives within a global team. Collaborate with colleagues to ensure lawful handling of pe...
5 days ago
Director, Medical Science Liaisons-Oncology
$221K - $368K *
Join a team that's dedicated to advancing oncology through leadership and innovation. Lead and develop a high-performing team of MSLs while driving strategic medical initiatives and fostering cross-fu...
1 week ago
Enterprise Account Executive, Observability
$150K - $180K *
Drive success by leveraging your expertise in enterprise sales to enhance customer engagement and expand market presence. Collaborate cross-functionally to deliver innovative solutions that empower or...
2 weeks ago
Director Chemistry Portfolio Growth
$149K - $303K *
Shape the future of cheminformatics by driving product strategy, competitive analysis, and pricing for growth. Collaborate across teams to enhance market positioning and empower sales, ensuring alignm...
Yesterday
$80K - $95K *
Accelerate progress at the forefront of scientific sales by driving growth across diverse markets. Leverage your expertise to build relationships and solve complex challenges while managing the full s...
1 week ago
$163K - $224K *
Join a team that's redefining People Operations by leading global service delivery, enhancing employee experiences, and driving operational excellence across Talent Acquisition and People processes fo...
Reposted 2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.