Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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Vice President, Sales Jobs in South Dakota

Sort By: Relevance

$135K - $160K *

Join a team that's redefining healthcare sales by leading strategic initiatives, managing a high-performing team, and driving revenue growth in the Physical Therapy and Rehab markets. Shape the future...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Join our dynamic team as a results-driven Account Executive, where you'll convert qualified leads into long-term customers, manage the full sales cycle, and build strong relationships with key decisio...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $150K *

Elevate your career by leading product operations, enhancing processes, and driving AI adoption. Collaborate with cross-functional teams to optimize product delivery and analytics, ensuring seamless c...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $120K *

Empower your career as a Sales Engineer, driving revenue through technical expertise and strategic collaboration. Engage with clients, deliver compelling demos, and streamline the sales process to ach...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$107K - $145K *

Drive growth by identifying and securing new business opportunities in risk management and medical education. Collaborate with teams to develop proposals, manage sales pipelines, and ensure alignment...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $118K *

Engage in driving revenue growth by expanding strategic partnerships and acquiring new enterprise clients. Merge expansion selling with net-new enterprise acquisition to establish a repeatable sales m...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Business Services

$109K - $163K *

Unlock new revenue streams by driving market strategies for public sector clients across Transit Signal Priority and Emergency Vehicle Preemption solutions. Lead engagement and negotiations with key m...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Transportation

$81K - $100K *

Deliver exceptional client service by managing strategic accounts, driving retention, and fostering growth. Collaborate with cross-functional teams to address customer needs and expand business opport...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$185K - $205K *

Elevate sales compensation operations by managing the variable budget, analyzing performance data, and ensuring accurate commission cycles. Collaborate with executives to optimize pay-for-performance...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$174K - $261K *

Empower enterprise transformation by leading a specialized sales team focused on cloud, data, and AI solutions. Drive strategic partnerships, coach high-performing sellers, and enhance technology stra...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$300K - $350K *

Transform business performance by leading strategic initiatives and continuous improvement efforts. Collaborate with senior leaders to drive accountability, enhance operational efficiency, and foster...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$95K - $105K *

Elevate client relationships by managing post-sale engagements, ensuring project success, and driving account growth. Collaborate with internal teams to deliver value and strengthen partnerships acros...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Elevate safety standards by leading a comprehensive safety strategy, fostering a proactive culture, and driving continuous improvement across multi-site operations while ensuring compliance with indus...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$175K - $225K *

Lead the charge in shaping product strategy and execution, driving innovation and collaboration across teams to deliver impactful solutions in a fast-paced B2B SaaS environment. Own the product roadma...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$180K - $215K *

Transform your career by leading regional sales efforts for a groundbreaking product. Drive performance, build a high-performing team, and engage with key healthcare providers in a fast-paced, entrepr...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Elevate your career by driving LPG tank sales across the Eastern US. Build lasting relationships with propane marketers and distributors while executing a results-driven commercial strategy to achieve...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$190K *

Champion operational excellence in the Americas, driving revenue performance through strategic leadership in sales, territory execution, and process optimization while fostering collaboration across t...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$125K - $150K *

Champion growth by driving sales strategies for pharmaceutical clients. Leverage your expertise to build relationships, develop tailored marketing solutions, and collaborate with teams to deliver exce...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$128K - $150K *

Help us drive growth in the Home Health and Pediatric Care sectors by generating new enterprise revenue. Own the full sales cycle, engage decision-makers, and develop strategic relationships to establ...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $200K *

Unlock potential by leading strategic sales initiatives that drive growth and forge strong relationships with key retail and eCommerce clients in a fast-paced environment requiring frequent travel. In...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$297K - $367K *

Grow your career with a pivotal role driving hospital data integration and compliance. Lead execution of clinical data operations, build relationships, and ensure secure data handling while shaping a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $250K *

Engage with diverse stakeholders to drive sales growth in FWA, M2M, and IoT solutions. Develop new customer relationships while enhancing existing accounts, leveraging a robust channel ecosystem to ma...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $200K *

Transform the enterprise account management landscape by leading strategy, driving revenue retention, fostering customer growth, and developing high-performing teams to enhance client relationships an...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $145K *

Drive growth by building strong partnerships with travel agencies, enhancing market share and brand awareness. Collaborate across teams to identify opportunities and execute strategies, making a signi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$95K *

Join a team that's driving growth by managing key Integrator accounts, developing sales strategies, and fostering relationships to exceed corporate goals in the material handling industry...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.