Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Vice President, Sales Jobs in Missouri

Sort By: Relevance

$90K - $100K *

Unlock your potential by driving sales growth in a dynamic territory. Collaborate with key accounts, identify new opportunities, and enhance customer relationships while executing strategic plans for...

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$180K - $220K *

Lead the global Accounting and Treasury function, driving financial systems, reporting, and IPO readiness while building a scalable team to support international growth and operational complexity...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$180K - $225K *

Drive strategic growth by acquiring new clients and expanding market presence in data center and rapid deployment sectors. Lead complex business development initiatives, fostering executive relationsh...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $180K *

Lead multifamily transactions from sourcing to closing, ensuring disciplined execution and strategic alignment across teams. Drive outcomes through strong negotiation, relationship management, and a r...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$135K - $175K *

Unlock the potential of our NTN device ecosystem by driving strategic partnerships with OEMs, chipset vendors, and manufacturers. Collaborate cross-functionally to align product roadmaps and ensure su...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$203K - $319K *

Lead and optimize commercial operations to drive growth, enhance revenue strategies, and streamline processes. Collaborate with cross-functional teams to ensure effective execution of sales initiative...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$103K - $128K *

Join us to lead product strategy and development, driving innovation and performance in healthcare solutions. Collaborate cross-functionally to align business needs with customer expectations and ensu...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$195K - $217K *

Drive client success by leading strategic initiatives and fostering strong relationships in healthcare technology. Leverage deep domain expertise to enhance outcomes and ensure effective use of soluti...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $360K *

Engage with strategic prospects to drive growth by modernizing HR, IT, and Finance management. Collaborate with teams to ensure seamless transitions and customer success while navigating complex sales...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Accelerate your career by leading a dynamic team in sales strategy execution, inventory management, and compliance. Drive growth and enhance customer engagement while ensuring safety and operational e...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$160K - $200K *

Shape the future of platform capabilities by leading strategy and execution for data, AI, and user experience initiatives. Collaborate with cross-functional teams to drive innovation and enhance custo...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$90K - $130K *

Drive sales growth in the Midwest by managing customer relationships, developing strategies, and coordinating sales activities. Collaborate with teams to ensure customer satisfaction and achieve terri...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$173K - $225K *

Drive strategic partnerships with healthcare organizations to enhance care for rare kidney diseases. Collaborate with cross-functional teams to align clinical and operational goals, ensuring impactful...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$134K - $249K *

Drive procurement governance strategy and compliance across the organization. Oversee contract standards, audit readiness, and policy implementation while ensuring ethical practices and effective comm...

Missouri, USRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$105K - $157K *

Drive the vision and strategy for Sales and Service GTM systems, leading cross-functional initiatives and optimizing Salesforce technologies to enhance operational efficiency and modernize legacy syst...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$180K - $220K *

Shape the future of enterprise technology by leading strategic partnerships and alliances. Drive growth through collaboration with top innovators in software, hardware, and security, while influencing...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$210K - $250K *

Partner with us to lead transformative HR initiatives in a dynamic professional services environment. Shape talent strategies, drive AI integration, and build a robust People Services practice that su...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Business Services

$150K - $180K *

Champion the growth of strategic travel partnerships by leading enterprise sales efforts, securing high-value accounts, and leveraging modern sales frameworks to drive commercial success in a fast-pac...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Join a dynamic sales team to drive growth in K-12 education, managing the full sales cycle and building strategic partnerships. Shape your territory strategy while enhancing digital learning environme...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$115K - $136K *

Innovate by driving new business opportunities with executive finance leaders. Leverage your consultative sales skills to deliver transformative SaaS solutions, ensuring measurable outcomes and buildi...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$119K - $142K *

Drive sales strategy and team performance in the Merchant acquiring sector, fostering growth and innovation. Lead, mentor, and develop a high-performing team while managing budgets and enhancing clien...

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Empower organizations by driving adoption of Power Platform solutions, modernizing systems, and automating processes. You'll develop new and existing relationships, collaborating with teams and partne...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Shape the future of affordable housing by managing LIHTC transactions from underwriting to closing. Collaborate with developers and investors to ensure timely execution and sound investment recommenda...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$200K - $250K *

Lead us in creating impactful marketing strategies, driving digital transformation, and fostering brand growth. Spearhead customer engagement initiatives, commercial excellence, and collaborative go-t...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$255K - $310K *

Lead a high-performing team to execute market access strategies, optimize payer engagement, and enhance product positioning. Drive collaboration across stakeholders to ensure effective reimbursement a...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.