Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$165K - $235K *

Drive the execution of DSO growth strategies, leading a team to achieve revenue targets through data-driven sales and cross-functional collaboration, while enhancing customer relationships and ensurin...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$200K - $230K *

Lead customer success initiatives by managing federal program delivery, ensuring seamless deployment, support, and renewal processes. Drive team performance and build strategic partnerships to enhance...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Empower your career by leading Channel Operations to enhance partner engagement, drive operational excellence, and foster team performance. Collaborate cross-functionally to maximize value and achieve...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Unlock insights and drive performance as you analyze data, develop countermeasures, and execute strategies in the field. Collaborate with sales teams to enhance dealer activation and reduce churn, ens...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Advance your career by overseeing complex accounting functions, ensuring compliance with GAAP, and leading financial reporting and analysis. Mentor junior staff while driving budgeting and forecasting...

2 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$146K - $182K *

Design and deliver impactful training programs to enhance sales capabilities, ensuring alignment with corporate objectives. Collaborate with cross-functional teams to drive effective onboarding and co...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Engage key customers to maximize revenue and profitability through strategic account planning, fostering value-driven relationships, and enhancing collaboration across business units for long-term gro...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Elevate your career by leading global Food Safety operations, driving strategy, and enhancing performance across multiple manufacturing sites. Collaborate with cross-functional teams to ensure safety...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $140K *

Engage with Private Equity firms to develop strategic partnerships, promoting supply chain services and driving revenue growth through effective channel management and collaboration with stakeholders...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

$100K - $130K *

Accelerate progress at client acquisition through strategic sales initiatives, fostering relationships, and managing accounts in the Northeast. Drive revenue growth while utilizing CRM tools and AI to...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$86K - $138K *

Lead the charge in defining product vision and strategy, aligning stakeholders, and overseeing execution. Collaborate across teams to prioritize clinical data assets, ensuring maximum business value a...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Advance your career by leading a high-performing sales team in the luxury automotive sector. Drive operational excellence, enhance customer experiences, and implement strategic sales initiatives to ac...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$80K - $96K *

Lead the charge in transforming client relationships through strategic outside sales. Inspire and mentor a dynamic team while managing your own portfolio, leveraging proven strategies to deliver tailo...

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Unlock potential by leading a dynamic sales team, nurturing client relationships, and driving business growth through tailored insurance solutions while enjoying the flexibility to set your own schedu...

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Inspire and lead a sales team while building client relationships and implementing effective strategies. Enjoy flexible scheduling and the opportunity to mentor others, all while providing tailored in...

Reposted 3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$280K - $300K *

Drive new business growth by leveraging innovative automation solutions. Build lasting client relationships and serve as a trusted advisor in the Agentic Process Automation space, while exceeding sale...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$112K - $143K *

Join us to drive business growth and expand relationships in a dynamic sales role. You'll manage key partnerships, execute strategic initiatives, and achieve revenue targets while maintaining a strong...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Join a team that's focused on driving growth in Healthcare and Financial Services. Leverage your enterprise sales expertise to build relationships, develop new business, and deliver impactful technolo...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$124K - $198K *

Transform your career by owning and accelerating Unstructured data protection sales. Leverage your technical expertise to drive growth, engage stakeholders, and win competitive deals in a dynamic, quo...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $140K *

Join a team that's driving growth in unstructured data protection. Leverage your technical expertise to engage with clients, lead discovery, and close deals while collaborating with sales and engineer...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$485K *

Transform franchise growth in the Extended Stay sector by leading strategic initiatives, managing a team of Regional Vice Presidents, and building key relationships to enhance development opportunitie...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$110K - $130K *

Drive growth and expand market presence by managing territory sales, developing customer relationships, and collaborating cross-functionally to achieve strategic objectives in the Motion Control secto...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$240K - $300K *

Join a team that's driving explosive growth in the SaaS sector! We're seeking a proven leader to scale our company from $30M to $100M ARR, focusing on profitable revenue generation and cross-selling a...

United StatesRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$157K - $283K *

Lead the charge in driving business growth by developing strategic partnerships and innovative solutions for federal clients, while collaborating with cross-functional teams to deliver exceptional res...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$120K - $140K *

Elevate sales growth in the refrigeration and HVAC/R sectors by driving market development, building key relationships, and implementing effective strategies to maximize customer engagement and produc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.